Antihypertensive agents, serum lipoproteins and glucose metabolism

Ferrari, Paolo; Rosman, Johan B.; Weidmann, P

doi:10.1016/0002-9149(91)90817-5

Cited by 72 publications

(25 citation statements)

References 102 publications

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“…The reason for the observed dierences in HDL-C between able-bodied and individuals with SCI are unclear. There are a number of factors that signi®cantly eect HDL-C. For example, cigarette smoking, 36,37 beta blockers or diuretics, 38,39 anti-spastic medication 38 decrease HDL-C, whereas moderate alcohol intake, 40,41 and physical activity 42 increase HDL-C. Diet may also eect HDL-C level although published results are inconsistent.…”

Section: Limitations Of Available Datamentioning

confidence: 99%

High density lipoprotein cholesterol in individuals with spinal cord injury: The potential role of physical activity

1999

Spinal Cord

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Study design/Methods: Literature review. Papers were selected from a literature search of both the Medline and Current Contents data bases and through extensive cross checking of references from the author's personal ®les. Objectives: To evaluate the evidence for a reduced level of HDL-C in individuals with spinal cord injury and to discuss physiologic and behavioral factors that may be responsible for the observed reduction, with emphasis on the role of physical activity. Results/Conclusions: The evidence presented suggests that HDL-C may be lower in persons with SCI; however, the available data should be interpreted cautiously due to lack of control for important confounding factors such as smoking, alcohol consumption and physical activity. Results suggest a potential association between increased physical activity and increased HDL-C in persons with SCI. However, the mode, frequency, intensity and duration of activity and the physiologic mechanism responsible for this association have yet to be clearly elucidated.

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Section: Limitations Of Available Datamentioning

confidence: 99%

High density lipoprotein cholesterol in individuals with spinal cord injury: The potential role of physical activity

1999

Spinal Cord

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“…[24][25][26][27] These agents are widely used for the treatment of hypertension and heart disease. Whereas their effects on total cholesterol and triglycerides are known, their effects on cholesterol subfractions is poorly documented.…”

Section: Introductionmentioning

confidence: 99%

Impact of an ACE inhibitor and calcium antagonist on microalbuminuria and lipid subfractions in type 2 diabetes: a randomised, multi-centre pilot study

Bakris¹,

Smith²,

Richardson³

et al. 2002

J Hum Hypertens

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Background: Microalbuminuria (MA) is associated with increased cardiovascular risk and lipid abnormalities in people with type 2 diabetes. ACE inhibitors and calcium channel blockers (CCBs) reduce MA and are neutral on total cholesterol and triglycerides. The effect of ACE inhibitors and CCBs on lipid subfractions such as Lp(a), apolipoprotein (apo) A1, apo B, and others, however, is unclear. The current study tests the hypothesis that a fixed-dose combination of an ACE inhibitor, benazepril (B) with the dihydropyridine CCB, amlodipine (A), will further reduce arterial pressure and reduce atherogenic lipid fractions compared to either agent alone. Design: A multicentre, randomised, open-label, parallel group design was used to study 27 participants with type 2 diabetes. Measurements for total cholesterol, high-and low-density lipoprotein (HDL and LDL), triglycerides, apo A1, apo B, Lp(a), MA, arterial pressure and creatinine clearance were obtained at baseline and at 12-week intervals during the 36 week study. Results: Arterial pressure was significantly reduced at 36 weeks in all three groups (P ‫؍‬ 0.0078 for A, P ‫؍‬

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“…6,[8][9][10]15 Our results suggest that by using simple anthropomethric and biochemical markers as a test, three-quarters of hypertensive subjects with hyperinsulinaemia у13.0 mU/l and almost all with hyperinsulinaemia у18.0 mU/l become identifiable, and that the test is feasible for both drug-treated and non-treated hypertensives. The weakness in our study is its cross-sectional nature and that the definition of hypertension was based on measurements being made on a single visit.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 To improve the treatment outcome of hypertension at the population level it would be of crucial importance to identify the insulin-resistant hypertensive subjects 10 in clinical practice in order to optimise their pharmacological and non-pharmacological treatment with respect to metabolic abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Hyperinsulinaemia in hypertensive subjects: validity of a test for the detection of insulin resistance in clinical practice

Mj¹,

Tk²,

et al. 1998

J Hum Hypertens

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Antihypertensive agents, serum lipoproteins and glucose metabolism

Cited by 72 publications

References 102 publications

High density lipoprotein cholesterol in individuals with spinal cord injury: The potential role of physical activity

High density lipoprotein cholesterol in individuals with spinal cord injury: The potential role of physical activity

Impact of an ACE inhibitor and calcium antagonist on microalbuminuria and lipid subfractions in type 2 diabetes: a randomised, multi-centre pilot study

Hyperinsulinaemia in hypertensive subjects: validity of a test for the detection of insulin resistance in clinical practice

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