Antiinflammatory effect of the Indian Ayurvedic herbal formulation Triphala on adjuvant‐induced arthritis in mice

The anti-inflammatory and antinociceptive activities of Triphala recipe were studied in animal models. Triphala recipe (4 mg/ear) significantly exhibited an inhibitory effect on the ear edema formation induced by ethyl phenylpropiolateinduced, but not on the arachidonic acid -induced ear edema in rats. Furthermore, Triphala recipe at the doses of 300, 600 and 1,200 mg/kg significantly reduced carrageenan-induced hind paw edema. Next, the anti-inflammatory action in chronic inflammation was measured using the cotton pellet-induced granuloma formation assay in rats. Triphala recipe (1,200 mg/kg) reduced neither transudative weight nor granuloma formation. It also did not affect on body weight gain and thymus weight indicating that Triphala recipe does not have a steroid-like effect. In antinociceptive study, Triphala recipe (300, 600, 1,200 mg/kg), elicited significant inhibitory effect on both phases, especially in late phase, of the formalin test in mice suggesting that the antinociceptive action of Triphala recipe may be via both peripheral and at least partly centrally acting.

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“…Moreover, this recipe has an anti-inflammatory activity on adjuvant-induced arthritis in mice (Rasool and Sabina, 2007).…”

Section: Introductionmentioning

confidence: 94%

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Sireeratawong¹,

Jaijoy²,

Soonthornchareonnon³

2013

Afr. J. Trad. Compl. Alt. Med.

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“…These powders were mixed in equal proportion (1:1:1) based on the formula of Ayurvedic Formulary of India. From the powder, the aqueous extract was prepared as described previously (Rasool & Sabina, 2007). The triphala powder used in this study was found to contain approximately 50% polyphenols as investigated by high-performance thin layer chromatography (HPTLC) densitometer analysis [toluene:ethyl acetate:glacial acetic acid-formic acid (20:45:20:05) solvent system].…”

Section: Drugmentioning

confidence: 99%

The anti-inflammatory effect oftriphalain arthritic-induced rats

Kalaiselvan

Rasool

2014

Pharmaceutical Biology

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Context: Triphala, an Indian Ayurvedic herbal formulation which contains Terminalia chebula Retz. (Combretaceae), Terminalia bellerica (Gaertn.) Roxb. (Combretaceae) and Emblica officinalis L. (Phyllanthaceae), is used for treating bowel-related complications, inflammatory disorders, and gastritis. Objective: To determine the anti-arthritic effect of triphala in arthritis-induced rats. For comparison purpose, the non-steroidal anti-inflammatory drug indomethacin was used. Materials and methods: Arthritis was induced in Wistar albino rats by intradermal injection of complete Freund's adjuvant (0.1 ml) into the foot pad of right hind paw. Triphala (100 mg/ kg b wt, i.p.) was administered from day 11 to 18 after the administration of complete Freund's adjuvant. The activities/levels of lysosomal enzymes, glycoproteins, antioxidant status, and lipid peroxidation were determined in the paw tissues of arthritic rats. In addition, the inflammatory mediators were also measured in both the serum and the paw tissue of arthritic rats. Results: The levels/activities of lipid peroxidation ($41.5%), glycoproteins (hexose $43.3%, hexosamine $36.5%, and sialic acid $33.7%), lysosomal enzymes (acid phosphatase $52.4%, b-galactosidase $22.9%, N-acetyl b-glucosaminidase $22.1%, and cathepsin-D $27.7%) were found to be decreased and the antioxidant status (SOD $75.6%, CAT $62.7%, GPx $55.8%, GST $82.1%, and GSH $72.7%) was increased in the paw tissues of triphala-treated arthritic rats. In addition, the inflammatory mediator levels in serum (TNF-a $75.5%, IL-1b $99%, VEGF $75.2%, MCP-1 $76.4%, and PGE 2 $69.9%) and in paw tissues (TNF-a $71.6%, IL-1b $75.5%, VEGF $55.1%, MCP-1 $69.1%, and PGE 2 $66.8%) were found to be suppressed. Conclusion: Triphala has a promising anti-inflammatory effect in the inflamed paw of arthritis-induced rats.

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“…Oral administration of Triphala (1 g/kg/bwt) reduces body weight, restore both physical and biochemical changes in rthritic animals and shows promising anti-inflammatory activity [ Table 1]. [61] SIDDHA FORMULATION Kalpaamruthaa (KA) is a modified indigenous Siddha formulation constituting SA nut milk extract, Emblica officinalis, and honey shows anti-inflammatory activity. KA exhibited enhanced effect on anti-inflammatory and antiarthritic properties than sole SA treatment, and the collective effect of KA might be due to the combined interactions of the phytochemicals such as flavonoids, tannins, and other compounds such as vitamin C present in KA.…”

Section: Triphalamentioning

confidence: 99%

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Upadhyay

2016

IJGP

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The present review explains reasons of arthritis a disease related to chronic joint pain and inflammation. It also emphasizes the use of bioactive principles of plant origin to be used to relieve from arthritic pain, aching, stiffness, and swelling. These plant natural products can finish rheumatic pain if they are used regularly according to physician' advice. There are so many active crude extracts and pure compounds which show anti-arthritic activity in Freund's complete adjuvant induced animal models. Certain Ayurvedic formulations also assist to relieve from rheumatic arthritic pain and tone up immune system to function normally. This article shows an overview of medicinal suggestions on the basis of experimental advances made in the herbal medicinal researches in recent years for the treatment of arthritis. There are various dietary supplements which could also provide for management of severe pain of joints, and mitigation of inflammation. It is also suggested that early diagnosis, proper treatment, and healthy dietary habits can reduce the disease spectrum and chronic inflammatory pain.

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Antiinflammatory effect of the Indian Ayurvedic herbal formulation Triphala on adjuvant‐induced arthritis in mice

Cited by 76 publications

References 30 publications

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

The anti-inflammatory effect oftriphalain arthritic-induced rats

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