Antimalarial and antimicrobial substances isolated from the endophytic actinomycete, Streptomyces aculeolatus MS1-6

Kuncharoen, Nattakorn; Bunbamrung, Nantiya; Intaraudom, Chakapong; Choowong, Wilunda; Thawai, Chitti; Tanasupawat, Somboon; Pittayakhajonwut, Pattama

doi:10.1016/j.phytochem.2022.113568

Cited by 8 publications

(9 citation statements)

References 25 publications

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“…Both 174 and 175 were obtained from the endophytic actinomycete S. aculeolatus. 174 The two siderophores 174 and 175 exhibited antitubercular activity with the same MIC value of 6.25 mg mL −1 . Furthermore, the bigger siderophore 174 showed an extra antimalarial activity with an IC 50 value of 7.07 mM.…”

Section: Reviewmentioning

confidence: 96%

Section: Structure and Bioactivity Of Polyamine-containing Natural Pr...mentioning

confidence: 99%

“…However, the dimethylated derivative of 174 was inactive against Mycobacterium tuberculosis and malaria, suggesting the importance of the two hydroxyl groups at N 6 and N 12 of 174 for its bioactivity. 174 Desferrioxamines (DFOs), including DFO-B (176), DFO-E (177), and DFO-G 1 (178), which were produced from various soil Streptomyces sp. and the plant pathogen Erwinia amylovora, are related hydroxamate siderophores containing three acylated N-hydroxycadaverine moieties.…”

Section: Reviewmentioning

confidence: 99%

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Polyamine-containing natural products: structure, bioactivity, and biosynthesis

Long,

Zhou,

Zhou

et al. 2024

Nat. Prod. Rep.

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Section: Reviewmentioning

confidence: 96%

Section: Structure and Bioactivity Of Polyamine-containing Natural Pr...mentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Polyamine-containing natural products: structure, bioactivity, and biosynthesis

Long,

Zhou,

Zhou

et al. 2024

Nat. Prod. Rep.

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“…Endophytic actinomycete bacterium Streptomyces aculeolatum MS1‐6 isolated from the medicinal plant Musa sapientum (dessert banana, known for anti‐inflammatory and anti‐oxidant activities) was shown to produce a series of compounds with anti‐bacterial and anti‐malarial activities (Kuncharoen et al., 2023). Six congeners of new naphthoquinone terpenoids aculeolatins were identified, and three of those exhibited significant anti‐bacterial and anti‐malarial activities while having low cytotoxicity.…”

Section: Bacterial Endophytes Of Medicinal Plants and Their Secondary...mentioning

confidence: 99%

Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery

Zotchev

2024

Microbial Biotechnology

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Among the plant‐associated microorganisms, the so‐called endophytes continue to attract much attention because of their ability not only to protect host plants from biotic and abiotic stress factors, but also the potential to produce bioactive secondary metabolites. The latter property can elicit growth‐promoting effects on plants, as well as boost the production of plant‐specific secondary metabolites with valuable pharmacological properties. In addition, endophyte‐derived secondary metabolites may be a rich source for the discovery of drugs to treat various diseases, including infections and cancer. However, the full potential of endophytes to produce bioactive secondary metabolites is often not revealed upon conventional cultivation in the laboratory. New advances in genomics and metabolic engineering offer exciting opportunities for the exploration and exploitation of endophytes' biosynthetic potential. This review focuses on bacterial endophytes of medicinal plants, some of their secondary metabolites and recent advances in deciphering their biosynthesis. The latter may assist in genetic engineering efforts aimed at the discovery of novel bioactive compounds with the potential to be developed into drugs.

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“…A review of the secondary metabolites from Trichoderma harzianum has appeared. 78 Several new cadinanes, including the chlorine-containing trichocadinin H (184), are found in the fungus Trichoderma virens RR-dl-6-8 isolated from the red alga Rhodomela confervoides from Dalian, China. This new compound exhibits growth inhibition of four marine phytoplankton species (IC 50 0.83−2.6 μg/mL).…”

Section: ■ Marine Fungimentioning

confidence: 99%

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Gribble

2024

J. Nat. Prod.

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The discovery of naturally occurring organohalogen compounds has increased astronomically in the 55 years since they were first discovered�from fewer than 50 in 1968 to a combined 7,958 described examples in three comprehensive reviews. The present survey, which covers the period 2021−2023, brings the number of known natural organohalogens to approximately 8,400. The organization is according to species origin, and coverage includes marine and terrestrial plants, fungi, bacteria, marine sponges, corals, cyanobacteria, tunicates, and other marine organisms.

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Antimalarial and antimicrobial substances isolated from the endophytic actinomycete, Streptomyces aculeolatus MS1-6

Cited by 8 publications

References 25 publications

Polyamine-containing natural products: structure, bioactivity, and biosynthesis

Polyamine-containing natural products: structure, bioactivity, and biosynthesis

Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

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