Antimalarial compounds from the aerial parts of Flacourtia indica (Flacourtiaceae)

Methanol Extract of Flacourtia indica Aerial Parts Induces Apoptosis via Generation of ROS and Activation of Caspases in Human Colon Cancer HCT116 Cells

“…Extractives of the medicinal plant Flacourtia indica have been reported to exert a broad range of pharmacological activities, such as antimalarial, hepatoprotective, analgesic, diuretic and anti-inflammatory activities (Eramma and Devaraja, 2013;Kaou et al, 2010;Kundu et al, 2013;Nazneen et al, 2009). Phytochemical investigation of the plant has revealed the presence of a wide variety of bioactive phytochemicals including coumarins (Nazneen et al, 2002) and phenolic glycosides (Kaou et al, 2010), of which a coumarin compound scoparone has been reported to possess anti-inflammatory (Jang et al, 2005) and anticancer activities .…”

“…Phytochemical investigation of the plant has revealed the presence of a wide variety of bioactive phytochemicals including coumarins (Nazneen et al, 2002) and phenolic glycosides (Kaou et al, 2010), of which a coumarin compound scoparone has been reported to possess anti-inflammatory (Jang et al, 2005) and anticancer activities . Because of the causal link between inflammation and cancer, numerous plant extractives as well as purified plant constituents retaining anti-inflammatory properties have been shown to possess anticancer activity (Abdull Razis and Noor, 2013;Sehitoglu et al, 2014).…”

“…F) Merr. (familyFlacourtiaceae; Bengali Name -Baichi, 'Madagascar plum' in English) is a medium-sized, bushy, thorny tree available in the rural areas of Bangladesh and India 1 (Kaou et al, 2010). Different parts of this plant have long been used in Ayurvedic medicine.…”

“…Different parts of this plant have long been used in Ayurvedic medicine. Previous studies have demonstrated the antibacterial (Eramma and Devaraja, 2013) antimalarial (Kaou et al, 2010), hepatoprotective (Nazneen et al, 2009) and anti-inflammatory (Kundu et al, 2013) activities of methanol extract of F. indica (FIM). Moreover, phytochemical analysis of the plant revealed the presence of several bioactive constituents, such as coumarins (Nazneen et al, 2002) and phenolic glycosides (Kaou et al, 2010).…”

“…Previous studies have demonstrated the antibacterial (Eramma and Devaraja, 2013) antimalarial (Kaou et al, 2010), hepatoprotective (Nazneen et al, 2009) and anti-inflammatory (Kundu et al, 2013) activities of methanol extract of F. indica (FIM). Moreover, phytochemical analysis of the plant revealed the presence of several bioactive constituents, such as coumarins (Nazneen et al, 2002) and phenolic glycosides (Kaou et al, 2010). Since plant polyphenols possess anticancer properties, the present study was aimed at investigating the possible anticancer activity of FIM in human colon cancer HCT116 cells and to elucidate its underlying mechanisms.…”