Antimalarial Drugs Alone May Still Have a Role in Rheumatoid Arthritis

Cusnir, Ina; Dobing, Selina; Jones, Niall; Russell, Anthony S.

doi:10.1097/rhu.0000000000000243

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…As diretrizes do Colégio Americano de Reumatologia recomendam o uso rotineiro dos antimaláricos no tratamento do lupus (123)(124)(125) . Na artrite reumatoide, os antimaláricos são drogas modificadoras de atividade da doença e são utilizados geralmente em associação com metotrexato e sulfassalazina, possibilitando menor dose das drogas e menos efeitos adversos associados (126)(127)(128) . (12,108) .…”

Section: Avaliação Da Segurança E De Efeitos Adversosunclassified

Estudo randomizado de cloroquina versus azatioprina, em associação com prednisona, no tratamento da hepatite autoimune

Falcão¹

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Background: The treatment of autoimmune hepatitis (AIH) with prednisone and azathioprine provides disease remission. However, a complete biochemical and histological response is unreachable in most patients. Chloroquine is an antimalarial drug used for treating rheumatological diseases. It was studied as a single drug for the maintenance of AIH remission in an open study, which suggested a lower risk of relapse in the chloroquine group. Aims: To evaluate a possible role of chloroquine and prednisone for AIH treatment in a randomized study. Methods: 57 AIH adult patients with indication of treatment were enrolled to receive azathioprine or chloroquine, both with varying doses of prednisone, from 2003 to 2012. For those who had maintained biochemical remission for 18 months, liver biopsy was performed to evaluate histological remission. The primary outcome was the achievement of complete response to treatment. A p-value < 0.05 was considered statistically significant. Results: There were no significant differences between the groups concerning clinical, serological, histological, and treatment features at baseline. The average age was 37.2 ± 16.84 years, 43.8% with advanced fibrosis (F3/4) at baseline. There was no statistical differences in biochemical (67.7% vs. 53.8%, p=0.41) or histological response rate (32.26% vs. 15.38%, p = 0.217), as well as in the mean prednisone dose. There was a higher rate of adverse effects in the chloroquine group, but a lower frequency of comorbidities in this group. Conclusion: When well tolerated, chloroquine with prednisone provided a complete therapeutic response in AIH patients with no statistical difference when compared to the standard treatment. (ClinicalTrials.gov NCT 02463331).

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Section: Avaliação Da Segurança E De Efeitos Adversosunclassified

Estudo randomizado de cloroquina versus azatioprina, em associação com prednisona, no tratamento da hepatite autoimune

Falcão¹

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HPLC methods for choloroquine determination in biological samples and pharmaceutical products

2021

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Chloroquine-induced Prolonged QT Interval in COVID-19 Patients in Indonesia: Case Series

Widyaningsih

Putra

Asmara

et al. 2021

Biomed. Pharmacol. J.

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The treatment of corona virus disease 2019 (COVID-19)remains in debate, and the use of chloroquine has not been validated by accurate clinical trials.The aim of this study was to provide the possible cardiotoxicity effect of chloroquine in patients with COVID-19. This study was a case-series of prolonged QT interval of COVID-19 patients treated with chloroquine in a hospital in Bali, Indonesia. There were two cases of COVID-19 with exhibited a prolonged QT interval after being administrated of chloroquine. The prolonged QT interval returned to normal after chloroquine was stopped.These cases alert us the cardiotoxicity effect of chloroquine and the need for serial electro-cardiography monitoring before and during therapy. In conclusion, although antiviral and anti-inflammation properties of chloroquine on COVID-19 are promising, its cardiotoxicity effects should be monitored closely for less harm to the patients.

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Antimalarial Drugs Alone May Still Have a Role in Rheumatoid Arthritis

Abstract: There are some patients with confirmed RA who without doubt respond well to antimalarials alone. It is hard to objectively measure whether mild disease activity, early treatment initiation, lack of smoking, or other factors are contributing to a good treatment response.

Cited by 4 publications

References 8 publications

Estudo randomizado de cloroquina versus azatioprina, em associação com prednisona, no tratamento da hepatite autoimune

Estudo randomizado de cloroquina versus azatioprina, em associação com prednisona, no tratamento da hepatite autoimune

HPLC methods for choloroquine determination in biological samples and pharmaceutical products

Chloroquine-induced Prolonged QT Interval in COVID-19 Patients in Indonesia: Case Series

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