Antimicrobial Action of Compositions Based on Thiosulfonates and Biosurfactants on Phytopathogens

Швец, В М; Карпенко, Олена; Карпенко, І. В.; Novikov, Volodymyr; Lubenets, V. І.

doi:10.20535/1810-0546.2017.3.96283

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…It is well known that synthetic esters of thiosulfonic acids exhibit a wide range of biological activity that often exceeds the efficiency of natural analogs. Some of these esters are proposed as effective antifungal compounds [4,5], promising substances for other applications [6][7][8][9][10][11][12], preservatives of fruits and vegetables, effective plant protection products, growth regulators, biocidal additives [7,[13][14][15], insecticides, and radioprotectors [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Thiosulfonates: The Prospective Substances against Fungal Infections

Lubenets¹,

Stadnytska²,

Baranovych³

et al. 2019

Fungal Infection

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The synthesis of new analogs of natural biologically active substances is a promising direction for the development of effective antifungal agents. Thiosulfonic acid esters (thiosulfonates) are the structural analogs of biocidal compounds from garlic, onion, cabbage, cauliflower, etc. More than 1000 thiosulfonates of various structures of the general formula RSO 2 SR' were synthesized at the Lviv Polytechnic National University, where their physicochemical properties were characterized. A high antifungal activity of the obtained substances was established in relation to the representatives of fungi of different genera. The thiosulfonates are perspective as basis for the development of effective antifungal means for the modern pharmaceutical, food industry, for the protection of various materials and agricultural products. To increase their effectiveness, antimicrobial compositions based on thiosulfonates and surfactants of microbial origin (biosurfactants) in the form of stable suspensions were developed and studied. It has been established that the use of biosurfactants in the compositions allows the enhancement of the antifungal activity of thiosulfonates and reduction of their active concentration. The possible mechanisms of the joint action of thiosulfonates and biosurfactants on fungal pathogens are proposed.

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Section: Introductionmentioning

confidence: 99%

Thiosulfonates: The Prospective Substances against Fungal Infections

Lubenets¹,

Stadnytska²,

Baranovych³

et al. 2019

Fungal Infection

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“…Further research. In order to improve the method for applying thiosulfonate biocide compounds to textile materials, it is advisable to develop highly stable nanosize water oligomer systems with thio sulfonates [32,33] as well as to improve the me thod for providing textile materials with antimicrobial properties and to ensure their stability and durability. The obtained results may be the source data for the development of scientifically substantiated requirements in the production of clothing for special and technical purposes.…”

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Innovative Approach to the Creation of Textile Materials with Antimicrobial Properties

et al. 2021

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Introduction. In recent years, there has been a constant search for more advanced and environmentally friendlymeans for antimicrobial treatment of cellulose-containing tissues of various intended uses in the textile industry.Problem Statement. The problem of protection of textile materials and products from microbiological destruction is complex and multifaceted and needs to be solved. Today, one of the methods of protection is to provide textile materials with biocidal properties, which not only prevents the growth of bacteria, but can also ensure a high level of tissue safety. Therefore, we are faced with the task of finding new safe biocidal products.Purpose. The research has been made to determine the level of safety of textile materials treated by biocidalsubstances with the thiosulfonate structure including Ethylthiosulfanilate, Methylthiosulfanilate and Allylthiosulfanilate.Materials and Methods. The fabrics of different chemical composition were used in the study, designed for themanufacture of overalls. New preparations of thiosulfonate structure were chosen for impregnation: ethylthiosulfanilate (ETS), methylthiosulfanilate (MTS) and allylthiosulfanilate (ATS). The presence of heavy metals and pesticides was determined by atomic absorption spectrometry with the use of a ZEENIT 650P spectrometer (Germany).Results. It has been established that the detected level of heavy metals and pesticides in the studied textile materials is insignificant and is within the regulatory requirements. It has been confirmed that the studied biocidal substances are low-toxic and environmentally friendly, because before and after treatment they did not change the hygienic parameters of tissues. A method for imparting biocidal properties to textile materials for the manufacture of overalls, in particular by impregnating textile materials with an alcoholic solution of biocidal products, has been developed. Also due to this treatment, the water absorption of materials decreases by an average of 40%.Conclusions. The treatment of textile materials with biocidal preparations of the thiosulfonate structure allowsobtaining simultaneously two desired effects for these fabrics: the appropriate bioresistance and water resistance.

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Predicted screening of biological activity of thiosulphonate pyrimidine derivatives

Monka¹,

Stadnytska²,

Charka³

et al. 2020

CTAS

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Pyrimidine and its derivatives are important objects for chemical synthesis and development of new drugs based on them. There is a practical application of a number of substances with a pyrimidine heterocycle in medical practice. We performed a predicted screening of biological activity, cytotoxicity and toxicity in rats of some synthesized pyrimidine thiosulfonates using appropriate on-line programs. It was found that they are low-toxic substances with a wide range of biological action and a high value of probable activity, which indicates the feasibility of continuing experimental studies of their biological action, in particular anticancer. S- (4,6- dimethylpyrimidin-2-yl) benzenesulfonothioate deserves special attention for in-depth study.

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Antimicrobial Action of Compositions Based on Thiosulfonates and Biosurfactants on Phytopathogens

Abstract: 1Відділення фізико-хімії горючих копалин Інституту фізико-органічної хімії та вуглехімії ім. Л.М. Литвиненка НАН України, Львів, Україна

Cited by 5 publications

References 7 publications

Thiosulfonates: The Prospective Substances against Fungal Infections

Thiosulfonates: The Prospective Substances against Fungal Infections

Innovative Approach to the Creation of Textile Materials with Antimicrobial Properties

Predicted screening of biological activity of thiosulphonate pyrimidine derivatives

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