Antimicrobial activities in vitro and in vivo of transition element complexes containing gold(I) and osmium(VI)

Abstract

Metal compounds have been used as antibacterial agents for centuries. The in-vitro activity of two metal containing complexes, one gold, the other osmium, was investigated using a panel of clinically isolated bacteria and Candida albicans. Twenty strains of each organism were used and MIC and MBC values determined using the agar plate dilution method. Protein binding effects on the activity of the compounds were also investigated using media supplemented with 5% human blood. In-vivo activity of the two compounds was subsequently determined in a hairless-obese mouse skin-surface activity model. Both compounds were highly active against the Gram-positive organisms and Candida albicans in vitro. The gold compound had some Gram-negative activity but the osmium complex was inactive against these organisms. Both were extensively protein bound. In the in-vivo experiment the gold compound achieved a 2-3 log reduction for all the test organisms and was at least as good as or superior to mupirocin in its eradication rate. The osmium compound was inactive.

Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates

“…In this last field, the compounds under investigation include a major collection of the type R 3 PAuL, in which the gold atom is coordinated to a phosphine ligand and L is an O- [26,27], N- [28,29], Cl- [30] or S- [29,[31][32][33][34][35] 2 ], Na 3 [Au(mna) 2 ] (H 2 mna 02-mercaptonicotinic acid) [13] and the cationic complexes [Au(L) 2 ](NO 3 ) 3 (L01-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) [34]. For the latter ligand, compounds of the type [Au(L)]Br, [Au(L)] SCN and [Au(L)]Cl were also prepared [34] and the coexistence of an S-donor ligand and a Cl ligand was also described for [LAuCl] (where L 02,3-diphenyl-1,3,4-thiadiazolium-5-thiolato-S exo ) [36].…”

In Vitro and In Vivo Antibacterial Activity of Some Organic and Inorganic Salts Against Asiatic Citrus Canker Agent Xanthomonas Citri Subsp. Citri

“…The antimicrobial activity of metal (II) complexes such as copper (II), zinc (II) and iron (II) (Osowole et al, 2012;Sharma et al, 2011;Chohan et al, 2006) against the vast range of pathogens such as bacteria and fungi has been recognized for a long time (Elsome et al, 1996;Osowole et al, 2012;Sharma et al, 2011). It was demonstrated that conidial germination and development of Helminthosporium solani could completely be inhibited by Iron salts (Mimee et al, 2011).…”

Synthesis, Characterization and Biological Activity of Mn(II)-Morin Complex

“…As therapeutic agents, usage of metal ions increases the drug action as well as coordination of metal ions to drug molecules also raise the drug efficacy [11,12]. The role of metal complexes has been recognized from centuries in antimicrobial activities and most fundamental breakthroughs are also known by them in medical history [13].…”