Antimicrobial activity in Asterceae: The selected genera characterization and against multidrug resistance bacteria

Gou, Junli; Lu, Youyuan; Xie, Mei; Tang, Xin‐Ying; Chen, Liang; Zhao, Jianjun; Li, Gang; Wang, Hanqing

doi:10.1016/j.heliyon.2023.e14985

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e14985

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Antimicrobial activity in Asterceae: The selected genera characterization and against multidrug resistance bacteria

Junli Gou¹,

Youyuan Lu²,

Mei Xie³

et al.

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Cited by 10 publications

(2 citation statements)

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“…1−5 Considering this botanical richness, it is not surprising that several Centaurea species have long been used in folk medicine for a variety of ailments, such as treatment of diabetes, diarrhea, hypertension, headache, muscle pains, microbial infections, rheumatism, and malaria. 6 Compounds virtually belonging to dozens of classes of secondary metabolites have been characterized in Centaurea species, but, undoubtedly, sesquiterpene lactones, 7,8 flavonoids, 9 and alkaloids 10 are the hallmark of this genus.Centaurea sicula L. is a Mediterranean species distributed in Spain, Southern Italy, Malta, Tunisia, and other countries of Northwestern Africa. 11 In Sicily, the Italian region that gives the name to the species, it is widespread in the uncultivated lands.…”

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confidence: 99%

“…Considering this botanical richness, it is not surprising that several Centaurea species have long been used in folk medicine for a variety of ailments, such as treatment of diabetes, diarrhea, hypertension, headache, muscle pains, microbial infections, rheumatism, and malaria . Compounds virtually belonging to dozens of classes of secondary metabolites have been characterized in Centaurea species, but, undoubtedly, sesquiterpene lactones, , flavonoids, and alkaloids are the hallmark of this genus.…”

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confidence: 99%

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Glucose Uptake-Stimulating Metabolites from Aerial Parts of Centaurea sicula

Serino,

Rigano,

Bruno

et al. 2024

J. Nat. Prod.

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A comprehensive phytochemical investigation of aerial parts obtained from Centaurea sicula L. led to the isolation of 14 terpenoids (1−14) and nine polyphenols (15−23). The sesquiterpenoid group (1−11) included three structural families, namely, elemanolides (1−6), eudesmanolides (7 and 8), and germacranolides (9−11) with four unreported secondary metabolites (5−8), whose structure has been determined by extensive spectroscopic analysis, including 1D/2D NMR, HR-MS, and chemical conversion. Moreover, an unprecedented alkaloid, named siculamide (24), was structurally characterized, and a possible biogenetic origin was postulated. Inspired by the traditional use of the plant and in the frame of ongoing research on compounds with potential activity on metabolic syndrome, all the isolated compounds were evaluated for their stimulation of glucose uptake, disclosing remarkable activity for dihydrocnicin (10) and the lignan salicifoliol (15).Centaurea is one of the most emblematic plant genera of the Mediterranean area, and with its hundreds of species (between 500 and 700, depending on the classification used), it is among the most numerous and taxonomically complex in the Cardueae tribe of the Asteraceae family. Centaurea plants can be annual, biennial, or perennial, rarely dwarf shrubs, with usually unarmed leaves. Along with the Iranian region, the Mediterranean area is one of the hotspots of distribution of the genus. 1−5 Considering this botanical richness, it is not surprising that several Centaurea species have long been used in folk medicine for a variety of ailments, such as treatment of diabetes, diarrhea, hypertension, headache, muscle pains, microbial infections, rheumatism, and malaria. 6 Compounds virtually belonging to dozens of classes of secondary metabolites have been characterized in Centaurea species, but, undoubtedly, sesquiterpene lactones, 7,8 flavonoids, 9 and alkaloids 10 are the hallmark of this genus.Centaurea sicula L. is a Mediterranean species distributed in Spain, Southern Italy, Malta, Tunisia, and other countries of Northwestern Africa. 11 In Sicily, the Italian region that gives the name to the species, it is widespread in the uncultivated lands. 12 Previous phytochemical investigations on this plant have reported the occurrence of sesquiterpene lactones, 13,14 flavonoids, 15 acetylenes, 16 and its essential oil composition. 17 Recently, the antioxidant properties of the plant extracts of specimens collected in Tunisia have been investigated. 18 In the frame of our research project aimed at the phytochemical profiling of species of the genus Centaur-

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confidence: 99%

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confidence: 99%

Glucose Uptake-Stimulating Metabolites from Aerial Parts of Centaurea sicula

Serino,

Rigano,

Bruno

et al. 2024

J. Nat. Prod.

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In‐Vitro Antimicrobial, Antidiabetic and Anticancer Activities of Calyptocarpus Vialis Extract and its Integration with Computational Studies

Bachhar,

Joshi,

Shekher Mishra

et al. 2024

ChemistrySelect

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Calyptocarpus vialis (C. vialis), a plant of Asteraceae family exhibits nutritional value, antioxidant properties and has potential for various other biomedical applications. The present study is focused to assess the antimicrobial, antidiabetic, and anticancer potential of C. vialis extract and its integration with computational studies. The antimicrobial activity is performed against the Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis) pseudomonas aeruginosa (P. aeruginosa), Escherichia coli (E. coli) bacteria and Saccharomyces cerevisiae (S. cerevisiae), Candida albicans (C. albicans) fungi using disc diffusion method. Maximum Zone of Inhibition (ZOI) of 37±3.2 and 35±2.9 mm is obtained for S. aureus and B. subtilis respectively, whereas ZOI of 39±2.8 mm is obtained against C. albicans at dose of 500 μg/mL. The extract shows strong α‐amylase inhibition activity with IC50 ~46.8±0.81 μg/mL inferring about its antidiabetic potential. Anticancer activity of C. vialis extract is checked against HCT‐116 and DU‐145 cell lines using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium‐bromide (MTT) assay, which shows excellent anticancer activity with IC50 value of 38.09±0.65 μg/ml and 36.34±1.05 μg/ml respectively. The obtained results are further verified using computational studies considering interaction among phytochemicals and selected targets. Extract is found potent for biological activities and promising candidate for development of new drugs.

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Unveiling the spectrum of antibiotic resistance and virulence genes in Escherichia coli: A comparative study of clinical and environmental isolates

Mahmud,

Shabnam,

Mishu

et al. 2024

Gene Reports

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Antimicrobial activity in Asterceae: The selected genera characterization and against multidrug resistance bacteria

Cited by 10 publications

References 172 publications

Glucose Uptake-Stimulating Metabolites from Aerial Parts of Centaurea sicula

Glucose Uptake-Stimulating Metabolites from Aerial Parts of Centaurea sicula

In‐Vitro Antimicrobial, Antidiabetic and Anticancer Activities of Calyptocarpus Vialis Extract and its Integration with Computational Studies

Unveiling the spectrum of antibiotic resistance and virulence genes in Escherichia coli: A comparative study of clinical and environmental isolates

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