Antimicrobial Activity of Carvacrol toward Bacillus cereus on Rice

Ultee, A.; Slump, R. A.; Steging, G; Smid, Eddy J.

doi:10.4315/0362-028x-63.5.620

Cited by 289 publications

(157 citation statements)

References 17 publications

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“…Baydar et al (2004) testaram um OEO com 53% de carvacrol e timol e outro OEO com 87% desses mesmos componentes e, como resultado, verificaram que o primeiro OEO, mesmo tendo menos carvacrol e timol, apresentou uma ação antimicrobiana mais efetiva por causa da presença de p-cimeno e γ-terpineno. Segundo Ultee et al (2000), o p-cimeno não tem efeito antibacteriano se usado sozinho, mas, quando combinado com carvacrol, ocorre sinergismo entre os dois. Neste trabalho, entre os cinco OEO avaliados, o óleo da marca E foi o que apresentou o menor teor de carvacrol (61,7%) e os maiores halos de inibição a partir da concentração 0,2%.…”

Section: Avaliação Da Composição Química De Oeo Das Marcas a B C D Eunclassified

Óleo essencial de orégano: interferência da composição química na atividade frente a Salmonella Enteritidis

Silva¹,

Duarte-Almeida²,

Pérez³

et al. 2010

Ciênc. Tecnol. Aliment.

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0,05), porém o OEO proveniente da região do Mediterrâneo com p-cimeno e γ-terpineno, além de carvacrol, apresentou maiores halos de inibição de SE que os demais OEO. Concluiu-se que a multiplicação de Salmonella Enteritidis in vitro pode ser inibida por OEO cuja ação antimicrobiana independe da região produtora de orégano. No entanto, óleos essenciais que possuem p-cimeno e γ-terpineno, além de carvacrol, podem ter o seu efeito antimicrobiano potencializado.]]>

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Section: Avaliação Da Composição Química De Oeo Das Marcas a B C D Eunclassified

Óleo essencial de orégano: interferência da composição química na atividade frente a Salmonella Enteritidis

Silva¹,

Duarte-Almeida²,

Pérez³

et al. 2010

Ciênc. Tecnol. Aliment.

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“…*P < 0.05; **P < 0.005, and ***P < 0.0005 compared to PBS control (ANOVA). (14,(32)(33)(34). However, the effect of other components present at lower percentage in the essential oil must be considered.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy

Mbarek

Mouse

Jaafari

et al. 2007

Braz J Med Biol Res

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The anti-tumor effect of the Moroccan endemic thyme (Thymus broussonettii) essential oil (EOT) was investigated in vitro using the human ovarian adenocarcinoma IGR-OV1 parental cell line OV1/P and its chemoresistant counterparts OV1/adriamycin (OV1/ADR), OV1/vincristine (OV1/VCR), and OV1/cisplatin (OV1/CDDP). All of these cell lines elicited various degrees of sensitivity to the cytotoxic effect of EOT. The IC 50 values (mean ± SEM, v/v) were 0.40 ± 0.02, 0.39 ± 0.02, 0.94 ± 0.05, and 0.65 ± 0.03% for OV1/P, OV1/ ADR, OV1/VCR, and OV1/CDDP, respectively. Using the DBA-2/ P815 (H 2 d ) mouse model, tumors were developed by subcutaneous grafting of tumor fragments of similar size obtained from P815 (murin mastocytoma cell line) injected in donor mouse. Interestingly, intratumoral injection of EOT significantly reduced solid tumor development. Indeed, by the 30th day of repeated EOT treatment, the tumor volumes of the animals were 2.00 ± 0.27, 1.35 ± 0.20, and 0.85 ± 0.18 cm 3 after injection with 10, 30, or 50 µL per 72 h (six times), respectively, as opposed to 3.88 ± 0.50 cm 3 for the control animals. This tumoricidal effect was associated with a marked decrease of mouse mortality. In fact, in these groups of mice, the recorded mortality by the 30th day of treatment was 30 ± 4, 18 ± 4, and 8 ± 3%, respectively, while the control animals showed 75 ± 10% of mortality. These data indicate that the EOT which contains carvacrol as the major component has an important in vitro cytotoxic activity against tumor cells resistant to chemotherapy as well as a significant antitumor effect in mice. However, our data do not distinguish between carvacrol and the other components of EOT as the active factor.

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“…This monoterpene is also easily available by the industrial pyrolysis of β-pinene, one of the major constituents of pine turpentine (Erman 1985;Lawrence 1989). p-Cymene is also a constituent of oregano and thyme oils but is less effective against food-related pathogens (Dorman and Deans 2000;Ultee et al 2000;Burt et al 2005) and is thought to be a precursor to carvacrol and thymol in the plant (Ultee et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Enhancing Production of Terpenoids in Metabolically Engineered Transgenic Spearmint (Mentha spicata L.) by Salt and Fungal Elicitors

Choi¹,

Park²,

Song³

et al. 2014

Journal of Forest and Environmental Science

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Forest tree species usually takes for long periods to be harvested and cultivated but spearmints are a good model system for woody plant because of reducing and shortening cultivation time. Spearmints are good model plants (Mentha species) for research about terpenoids production and industrial essential oil manufacture. Isopentenyl pyrophosphate isomerase (Iso) and limonene synthase (Limo) are the key enzymes of terpenoid biosynthesis pathway. Transgenic and wild spearmints (Mentha spicata, MS) were cultured in vitro and assessed for the essential oil contents. The content of essential oil of transgenic spearmint also was enhanced slightly depending on the target terpenoid genes. In an attempt to increase productivity of terpenoids further, salt and fungal elicitation strategy was adopted on transgenic Mentha spicata. The salt (800 mM NaCl) as abiotic and two fungi (Botrytis cinerea and Glomerella cingulata) as biotic were used for elicitors.In the absence of salt stress four terpenoids were detected from the spearmint extracts, all of them being monoterpenes. On the other hand, the transgenic (MSIso) extracts contained eleven terpenoids (10 monoterpenes and 1 phenylpropene) while transgenic (MSLimo) extracts contained seven monoterpenes. After 3 days of fungal infection, the resistance indices further increased to 4.38, 3.89 and 2.04 for wild type, MSIso and MSLimo, respectively. The salt and fungal elicitators proved beneficial towards modifying both the terpenoids profile and improvement in the composition of essential oil. These results have important applications for the large-scale production of essential oils and forest biotechnology with respect to spearmint.

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Antimicrobial Activity of Carvacrol toward Bacillus cereus on Rice

Cited by 289 publications

References 17 publications

Óleo essencial de orégano: interferência da composição química na atividade frente a Salmonella Enteritidis

Óleo essencial de orégano: interferência da composição química na atividade frente a Salmonella Enteritidis

Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy

Enhancing Production of Terpenoids in Metabolically Engineered Transgenic Spearmint (Mentha spicata L.) by Salt and Fungal Elicitors

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