Antimicrobial Activity of Novel Functionally Substituted Monocyclic and Spirocyclic Cyclohexane Derivatives

Abstract

Authors' Contribution MS, KG and AI designed the study and conducted the experiment. AI provided chemical compounds. AI and SU helped in writing the manuscript.

In vitro antimicrobial activity of 2,4-Diacetyl-5-hydroxy-5-methyl-3-phenyl-N-oxyethyl1-cyclohexenylamine

“…It is evident that test compound was more active against Gram-negative bacteria as compared to Gram-positive bacteria. Our findings are concurrent with [6], who showed that monocyclic and spirocyclic cyclohexane derivatives were more active against Gram-negative bacteria as compared to Gram-positive bacteria. The findings of [7] contradict our results, which is due to difference in structure of the test compound.…”

Antimicrobial activity and time kill curve study of newly synthesized dialkyl carboxylate cyclohexane derivative; A novel anti-Pseudomonas aeruginosa compound

“…Contrary to this, all the tested Gram-positive bacteria were found to be resistant against the test compound. Our results are supported by our previous studies (Shoaib et al, 2019c), which showed that ethyl, isopropyl and butyl carboxylate cyclohexane derivatives were more potent Acta Scientiarum. Technology, v. 44, e58868, 2022 against Gram-negative bacteria as compared to Gram-positive bacteria.…”

“…Functionally substituted monocyclic and spirocyclic cyclohexane derivatives showed better antimicrobial activity against Gram-negative bacteria. These results are synchronized with our findings (Shoaib et al, 2020). = Toluenesulfonyl derivatives of pyrazoles annelated with polyfunctional cyclohexane ring also exhibited better antibacterial properties against Gram-negative bacteria as compared to Gram-positive bacteria (Ismiyev, Shoaib, Ganbarov, & Agayeva, 2019).…”

“…Functionally substituted synthetic organic compounds with higher antimicrobial profile and mode of action which is not known by resistance mechanisms of bacteria are considered as potential antimicrobial agents of future (Tsemeugne et al, 2018). Due to ever increasing antimicrobial resistance, functionally substituted cyclohexane derivatives are being widely explored as probable antimicrobial agents (Shoaib, Ismiyev, Ganbarov, Israyilova, & Umar, 2020). These cyclohexane derivatives have shown diverse biological properties i.e.…”

“…Functionally substituted dialkyl carboxylate cyclohexane derivatives have exhibited variable antimicrobial activity. These compounds have shown moderate to strong antibacterial activity especially against Gramnegative bacteria (Urzua, Echeverria, Rezende, & Wilkens, 2008;Shoaib et al, 2019c). Keeping in view the above mentioned facts, the aim of the current research is to report synthesis, antimicrobial activity and time kill curve study of novel functionally substituted dialkyl carboxylate cyclohexane derivative.…”