Antimicrobial activity of polystyrene particles coated by photo-crosslinked block copolymers containing a biocidal polymethacrylate block

Lenoir, Sandrine; Pagnoulle, Christine; Detrembleur, Christophe; Galleni, Moreno; Jérôme, Robert

doi:10.1515/epoly.2005.5.1.783

Cited by 12 publications

(17 citation statements)

References 9 publications

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“…Jérôme and coworkers have published a series of reports on antimicrobial particles, blends, and coatings [82][83][84]. In terms of the synthesis and biological evaluation of their antimicrobial polymers in solution, they have studied a block copolymer, 20, in Fig.…”

Section: Polymers Containing Quaternary Ammoniums or Quaternary Pyridmentioning

confidence: 99%

Infectious disease: Connecting innate immunity to biocidal polymers

Gabriel

Som

Madkour

et al. 2007

Materials Science and Engineering: R: Reports

253

258

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Infectious disease is a critically important global healthcare issue. In the U.S. alone there are 2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 billion dollars of added healthcare costs. Couple these numbers with the appearance of new antibiotic resistant bacterial strains and the increasing occurrences of community-type outbreaks, and clearly this is an important problem. Our review attempts to bridge the research areas of natural host defense peptides (HDPs), a component of the innate immune system, and biocidal cationic polymers. Recently discovered peptidomimetics and other synthetic mimics of HDPs, that can be short oligomers as well as polymeric macromolecules, provide a unique link between these two areas. An emerging class of these mimics are the facially amphiphilic polymers that aim to emulate the physicochemical properties of HDPs but take advantage of the synthetic ease of polymers. These mimics have been designed with antimicrobial activity and, importantly, selectivity that rivals natural HDPs. In addition to providing some perspective on HDPs, selective mimics, and biocidal polymers, focus is given to the arsenal of biophysical techniques available to study their mode of action and interactions with phospholipid membranes. The issue of lipid type is highlighted and the important role of negative curvature lipids is illustrated. Finally, materials applications (for instance, in the development of permanently antibacterial surfaces) are discussed as this is an important part of controlling the spread of infectious disease.

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Section: Polymers Containing Quaternary Ammoniums or Quaternary Pyridmentioning

confidence: 99%

Infectious disease: Connecting innate immunity to biocidal polymers

Gabriel

Som

Madkour

et al. 2007

Materials Science and Engineering: R: Reports

253

258

View full text Add to dashboard Cite

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“…coated with tri-block copolymers of dimethylaminoethyl methacrylate. [13] The polystyrene-silver nanoparticles were modified for antimicrobial activity against Escherichia coli and Staphylococcus aureus. [14,15] The objective of the present work was to evaluate the potential use of chitosan and polystyrene nanoparticles as an additive for antibacterial property on cotton fabrics.…”

Section: Introductionmentioning

confidence: 99%

Potential Antibacterial Activity of Polystyrene Nanoparticles/Chitosan Coated on Cotton Fabrics

Siralertmukul

Watcharamul

Wicheanpaisan

et al. 2015

Macromolecular Symposia

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Summary: This research is to study the potential of using polystyrene nanoparticles and chitosan solution to increase the anti-bacterial activity on cotton fabrics prepared by a conventional pad-dry-cure method. Firstly, cotton fabrics were coated with chitosan solutions at the concentrations of 0.1, 0.5, and 1.0 (%w/v) and tested for the antibacterial property which was determined by clear zone measurement and viable count assay using Escherichia coli (ATCC 25922) as a tested microorganism. The results showed that, the percentage bacterial reductions were 87.2, 86.3, and 48.5%, respectively, when the cotton fabrics was coated only with chitosan solution. When polystyrene nanoparticle solution was coated onto cotton fabrics prior to coating with chitosan solutions at the concentrations of 0.1, 0.5, and 1.0 (%w/v), the percentage bacterial reductions were 90.3, 90.8, and 65.5%, respectively. This indicated that coating the cotton fabrics with polystyrene nanoparticles prior to chitosan coating would remarkably increase the antibacterial activity. The scanning electron micrographs showed that polystyrene nanoparticles were aggregated and inserted in between the interfiber spacings. The thin film of chitosan was also observed on the surface of cotton fabrics and hydrophobic property of the fabrics was tested via contact angle measurement.

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“…In most previous studies on the antibacterial activity of materials grafted with quaternized pDMAEMA, incubation in the bacterial suspension was for a given short time and the antibacterial effect was measured by simply counting the number of bacteria in the suspension [12][13][14][15]. However, since the bacteria adhere strongly to these materials, simple washing may not detach bacteria.…”

Section: Antibacterial Assaymentioning

confidence: 99%

“…Quaternized pDMAEMA has much higher antibacterial ability than unquaternized pDMAEMA, acting as a cation biocide that has been shown to kill most Gram-negative and Gram-positive bacteria [9]. pDMAEMA has been attached to various flat substrates, including glass [12,13], polystyrene [14] and polypropylene [15]. These materials have been shown to have antibacterial properties, albeit at a modest level, and it has been found that the antibacterial effect increases with the graft density of pDMAEMA [16].…”

Section: Introductionmentioning

confidence: 99%