Antimicrobial and Cytotoxic Terpenoids from Cymbopogon citratus Stapf.

Ragasa, Consolacion Y.; Hạ, Huỳnh Kỳ Phương; Hasika, M.; Maridable, Julius B.; Gaspillo, Pag-asa D.; Rideout, John A.

doi:10.3860/psci.v45i0.995

Cited by 13 publications

(22 citation statements)

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“…The secondary carbons C-4 and C-5 were represented by signals δ 40.6/25.7 and 32.6/27.0. The signals of carbons C-8 (δ 17.7) and C-9 (δ 25.6) displayed the same chemical shift for neral and geranial, but the peaks observed to C-10 were observed at δ 25.1 to neral and δ 17.6 to geranial, according to literature data [30,31]. Finally, analysis of 1 H NMR spectrum indicated a ratio of 5:3 of geranial:neral based in the integration of the doublets at δ 9.99 ( J = 9.0 Hz) and 9.89 ( J = 9.0 Hz), assigned to aldehyde hydrogens (H-1).…”

Section: Resultssupporting

confidence: 76%

Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae)

et al. 2016

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Backgroud: Lippia alba (Verbenaceae) is a plant widely used in folk medicine to treat various diseases. The present work deals with the chemical composition of the crude essential oil extracted from leaves of L. alba and evaluation of its antimicrobial and cytotoxic activities. Methods: Leaves of L. alba were extracted by hydrodistillation and analyzed by gas chromatography/mass spectrometry (GC/MS) as well as by nuclear magnetic resonance (NMR) spectroscopy. Cytotoxic and antimicrobial activities of crude essential oil were evaluated in vitro using MTT and broth microdilution assays, respectively. Results: Chemical analysis afforded the identification of 39 substances corresponding to 99.45% of the total oil composition. Concerning the main compounds, monoterpenes nerol/geraniol and citral correspond to approximately 50% of crude oil. The cytotoxic activity of obtained essential oil against several tumor cell lines showed IC50 values ranging from 45 to 64 µg/mL for B16F10Nex2 (murine melanoma) and A549 (human lung adenocarcinoma). In the antimicrobial assay, was observed that all tested yeast strains, except C. albicans, were sensitive to crude essential oil. MIC values were two to four-folds lower than those determined to bacterial strains. Conclusion: Analysis of chemical composition of essential oils from leaves of L. alba suggested a new chemotype nerol/geraniol and citral. Based in biological evidences, a possible application for studied oil as an antifungal in medicine, as well as in agriculture, is described.

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Section: Resultssupporting

confidence: 76%

Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae)

et al. 2016

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“…Typhi, E. coli [49]3. Allium sativum Organosulphur compounds (Phenolic compounds), Allicin Campylobacter jejuni , MDR E. coli , C. albican , Entamoeba histolytica , Giardia lamblia [50,51]4. Angelica lucida L.Coumarins S. viridians , S. mutans [33]5. Chelidonian majus Glycoprotein B. cereus , Staphylococcus spp.[52]6. Cinnamomum spp.Cinnamaldehyde (essential oil) Legionella pneumophila , MDR E. coli , C. albican , K. pneumoniae [53]7. Cirsium hypoleucum Flavones MDR K. pneumoniae [31]8. Curcuma longa Curcuminoid (A phenolic compound), turmerone, curlone, Essential oil, curcumins, turmeric oil S. typhi , E. coli , S. aureus , B. cereus , B. subtilis , Ps. aeruginosa , B. coagulans , A. niger , P. digitatum , Antifungal and antiviral activity[54]9. Cymbopogan citratus Essential oil C. albicals , Aspergillus flavus , A. parasiticus [36]10. Galium fissurense Flavones MDR K. pneumoniae [31]…”

Section: Table A1mentioning

confidence: 99%

Antimicrobial Resistance and the Alternative Resources with Special Emphasis on Plant-Based Antimicrobials—A Review

Chandra

Bishnoi

Yadav

et al. 2017

Plants

302

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Indiscriminate and irrational use of antibiotics has created an unprecedented challenge for human civilization due to microbe’s development of antimicrobial resistance. It is difficult to treat bacterial infection due to bacteria’s ability to develop resistance against antimicrobial agents. Antimicrobial agents are categorized according to their mechanism of action, i.e., interference with cell wall synthesis, DNA and RNA synthesis, lysis of the bacterial membrane, inhibition of protein synthesis, inhibition of metabolic pathways, etc. Bacteria may become resistant by antibiotic inactivation, target modification, efflux pump and plasmidic efflux. Currently, the clinically available treatment is not effective against the antibiotic resistance developed by some bacterial species. However, plant-based antimicrobials have immense potential to combat bacterial, fungal, protozoal and viral diseases without any known side effects. Such plant metabolites include quinines, alkaloids, lectins, polypeptides, flavones, flavonoids, flavonols, coumarin, terpenoids, essential oils and tannins. The present review focuses on antibiotic resistance, the resistance mechanism in bacteria against antibiotics and the role of plant-active secondary metabolites against microorganisms, which might be useful as an alternative and effective strategy to break the resistance among microbes.

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“…infectious diseases, respiratory tract infections [98] roots not yet identified (roots ethanol extract) S: Sa, Sp, Spn, Hi citral showed antifungal activity against C. albicans [34]. Also the diterpenoid trichorabdal A [35] was found to be active against Helicobacter pylori.…”

Section: Zingiber Officinalementioning

confidence: 99%

“…Alkaloids from Cameroonian medicinal plants (• " Fig. 5) were mostly isolated in three families including Rutaceae (Tecla afzelii) [34], Caesalpiniaceae (Erythrophleum suaveolens) [75] and Apocynaceae (Tabernaemontana crassa) [76]. The presence of alkaloids in these plant families has also been reported [74].…”

Section: Alkaloidsmentioning

confidence: 99%

Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review

2010

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Antimicrobial and Cytotoxic Terpenoids from Cymbopogon citratus Stapf.

Cited by 13 publications

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Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae)

Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae)

Antimicrobial Resistance and the Alternative Resources with Special Emphasis on Plant-Based Antimicrobials—A Review

Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review

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