Antimicrobial, anticancer and DNA binding studies of transition metal(II) complexes containing 2-phenyl-4-selenazole carboxylic acid

Synthesis of selenoureas and heterocycles based thereon

“…Organoselenium compounds are used as ligands in asymmetric catalysis [10] and promising "green chemistry" catalysts [11]. Selenium-containing organic compounds can be used in cancer therapy [12][13][14][15][16][17][18][19][20][21], in particular as cancer cell proliferation inhibitors [22][23][24][25][26][27][28][29][30][31][32], and they exhibit antihypertensive [33], antibacterial [13,[34][35][36][37][38][39], antifungal [40,41], antiparasitic [42], and antimicrobial activity [43]. During the past decade various selenium derivatives have been tested for biological activity as free radical [44][45][46] and superoxide anion scavengers [47], antioxidants [48][49][50][51][52][53], anti-inflammatory agents, and microglial activation inhibitors [54].…”

Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds

“…Moreover, some of them have shown potent antitumor and anticancer activities (Figure D) . On the other hand, 1,3-selenazoles, as seleno-analogues of 1,3-thiazoles, have also been studied extensively because of their potential pharmacological and biological behaviors, including antibacterial, antitumor, anticancer, antimicrobial, antiviral, and antimelanogenic activity (Figure E and F) …”

“…20 Moreover, some of them have shown potent antitumor and anticancer activities (Figure 1D). 21 On the other hand, 1,3selenazoles, as seleno-analogues of 1,3-thiazoles, have also been studied extensively because of their potential pharmacological and biological behaviors, including antibacterial, 22 antitumor, 23 anticancer, 24 antimicrobial, 25 antiviral, 26 and antimelanogenic activity (Figure 1E and F). 27 Despite the significance and unique behaviors of these compounds, limited synthetic approaches have been introduced for the preparation of these scaffolds in the literature.…”