Antimicrobial, antioxidant and anticancer activity of biogenic silver nanoparticles – an experimental report

Bhakya, S.; Muthukrishnan, S.; Sukumaran, M.; Grijalva, Marcelo; Cumbal, Luis; Benjamin, J. H. Franklin; Kumar, T. Senthil; Rao, M. S.

doi:10.1039/c6ra17569d

Cited by 53 publications

(19 citation statements)

References 53 publications

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“…AgNPs also displayed strong reducing power, which might be attributed to the presence of phenolic compounds from ACL extract on the surface of AgNPs as surface stabilizers and capping agents. It is observed in the present investigation that the antioxidant activity of the AgNPs was higher than that of the standard ASA which might be possible due to the size and crystalline nature of the AgNPs as reported by various authors ( El-Rafie and Abdel-Aziz Hamed, 2014 ; Bhakya et al, 2016 ; Gopukumar et al, 2016 ).…”

Section: Discussionsupporting

confidence: 55%

Antibacterial Activity and Synergistic Antibacterial Potential of Biosynthesized Silver Nanoparticles against Foodborne Pathogenic Bacteria along with its Anticandidal and Antioxidant Effects

2017

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Silver nanoparticles plays a vital role in the development of new antimicrobial substances against a number of pathogenic microorganisms. These nanoparticles due to their smaller size could be very effective as they can improve the antibacterial activity through lysis of bacterial cell wall. Green synthesis of metal nanoparticles using various plants and plant products has recently been successfully accomplished. However, few studies have investigated the use of industrial waste materials in nanoparticle synthesis. In the present investigation, synthesis of silver nanoparticles (AgNPs) was attempted using the aqueous extract of corn leaf waste of Zea mays, which is a waste material from the corn industry. The synthesized AgNPs were evaluated for their antibacterial activity against foodborne pathogenic bacteria (Bacillus cereus ATCC 13061, Listeria monocytogenes ATCC 19115, Staphylococcus aureus ATCC 49444, Escherichia coli ATCC 43890, and Salmonella Typhimurium ATCC 43174) along with the study of its synergistic antibacterial activity. The anticandidal activity of AgNPs were evaluated against Candida species (C. albicans KACC 30003 and KACC 30062, C. glabrata KBNO6P00368, C. geochares KACC 30061, and C. saitoana KACC 41238), together with the antioxidant potential. The biosynthesized AgNPs were characterized by UV-Vis spectrophotometry with surface plasmon resonance at 450 nm followed by the analysis using scanning electron microscope, X-ray diffraction, Fourier-transform infrared spectroscopy and thermogravimetric analysis. The AgNPs displayed moderate antibacterial activity (9.26–11.57 mm inhibition zone) against all five foodborne pathogenic bacteria. When AgNPs were mixed with standard antibacterial or anticandidal agent, they displayed strong synergistic antibacterial (10.62–12.80 mm inhibition zones) and anticandidal activity (11.43–14.33 mm inhibition zones). In addition, the AgNPs exhibited strong antioxidant potential. The overall results highlighted the potential use of maize industrial waste materials in the synthesis of AgNPs and their utilization in various applications particularly as antibacterial substance in food packaging, food preservation to protect against various dreadful foodborne pathogenic bacteria together with its biomedical, pharmaceutical based activities.

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Section: Discussionsupporting

confidence: 55%

Antibacterial Activity and Synergistic Antibacterial Potential of Biosynthesized Silver Nanoparticles against Foodborne Pathogenic Bacteria along with its Anticandidal and Antioxidant Effects

2017

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“…The recent report of Naveen kumar et al, 2018a , Naveen kumar et al, 2018b reported that the ROS is a major target to inhibit the cancer cells, and performed Ag NPs has stimulated the oxidative stress responses vigorously in A549 cells. Recently, Bhakya et al, (2016) was reported similar result against A549 cells by treating the Ag NPs at increased concentration. Also, the oxidative stress response went to down regulating process in apoptotic genes and leads to programmed cell death due to the intracellular leakages in mitochondrial membrane.…”

Section: Resultsmentioning

confidence: 57%

“…After respective time interval, the Ag NPs was generated the ROS in A549 cancer cells due to the oxidation process, and it accumulate on the DNA granules. Next, the DNA lost their transferring ability and blocked the polymerase enzyme production ( Bhakya et al, 2016 ). In outside, the surrounding membrane was completely damaged and immature colonies were observed.…”

Section: Resultsmentioning

confidence: 99%

Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

Tian

Saravanan

Mothana

et al. 2020

Saudi Journal of Biological Sciences

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The biosynthesized Ag NPs was synthesized by using marine mangrove plant extract Avicennia marina . The synthesized Ag NPs was confirmed by various physiochemical characterization including UV-spectrometer and XRD analysis. In addition, the shape and of the synthesized Ag NPs was morphologically identified by SEM initially and TEM finally. After confirmation, the anti-cancer property of synthesized Ag NPs was confirmed at 50 µg/mL concentration against A549 lung cancer cells by MTT assay. Further, the ability to stimulate the ROS generation and mitochondrial membrane at the IC 50 concentration of Ag NPs was confirmed by fluorescence microscopy using DCFH-DA and rhodamine 123 dyes respectively. Finally, the result was concluded that the synthesized Ag NPs has improved anti-cancer activity against A549 cells at lowest concentration.

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“…In vitro anti-cancer activity of metal bionanoparticles has been confirmed against different cancer cell lines, i.e. MDA-MB-231 and MCF-7 (human breast adenocarcinoma) (32,33), A549 (human lung adenocarcinoma) (34,35), HCT116 (human colon colorectal carcinoma) (36), HeLa (human cervical cancer) (37,10,38), NCI-H460 (non-small cell lung cancer) (39) (72,73), C26 (murine colon carcinoma) (74), LoVo (human colon adenocarcinoma) (75), LoVo/DX (multidrug resistance human colon adenocarcinoma sub-line) (75). The anticancer activity of various metal bionanoparticles from different bio-sources has been listed in Tables 1 and 2 from studies conducted in recent years by several research groups.…”

Section: Anti-cancer Activity Of Green Nanomaterials: a Mechanistic Amentioning

confidence: 96%

Anti-cancer green bionanomaterials: present status and future prospects

Barabadi

Ovais

Shinwari

et al. 2017

Green Chemistry Letters and Reviews

186

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Cancer is one of the most common health problems responsible for outnumbered deaths worldwide. Nanomedicine plays an important role in developing alternative and more effective treatment strategies for cancer theranostics. However, the toxicity, high cost and nanoparticles (NPs) production complexity are some of the major issues that obstruct the use of existing nanomedicine. Recently, the green synthesis of biogenic NPs from plants and microbial sources has become an emerging field due to their safer, eco-friendly, simple, fast, energy efficient, lowcost and less toxic nature. Interestingly, NPs play a key role in diagnosis of tumor at the initial stage by allowing cellular visualization. Furthermore, prospective applications of green NPs include magnetically responsive drug delivery, anti-cancer activity, photo-thermal therapy and bio-imaging. The present review provides perspective on the use of anti-cancer green bionanomaterials with a focus on their present status and future prospects in the theranostics of cancer.

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Antimicrobial, antioxidant and anticancer activity of biogenic silver nanoparticles – an experimental report

Abstract: In the present study, use of a Helicteres isora stem bark extract for the biosynthesis of AgNPs is described.

Cited by 53 publications

References 53 publications

Antibacterial Activity and Synergistic Antibacterial Potential of Biosynthesized Silver Nanoparticles against Foodborne Pathogenic Bacteria along with its Anticandidal and Antioxidant Effects

Antibacterial Activity and Synergistic Antibacterial Potential of Biosynthesized Silver Nanoparticles against Foodborne Pathogenic Bacteria along with its Anticandidal and Antioxidant Effects

Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

Anti-cancer green bionanomaterials: present status and future prospects

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