Antimicrobial characteristics in Cu-containing Zr-based thin film metallic glass

Chu, Jia Hong; Lee, Joseph; Chang, Chun Ming; Chan, Yu-Chen; Liou, Ming-Li; Lee, Jyh-Wei; Jang, J.S.C.; Duh, Jenq Gong

doi:10.1016/j.surfcoat.2014.05.019

Cited by 50 publications

(33 citation statements)

References 33 publications

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“…Figure 5 shows the survival rate for the same samples after 1, 2, 3 and 4 h of contact time. The calculation has been done using the equation reported by Chu et al [23] but expressed as the survival rate:

Survival rate = 1 - \frac{{CFU}_{S . Steel} - {CFU}_{Sample}}{{CFU}_{S . Steel}},

where CFU S.Steel and CFU Sample are the recovered E. Coli colony-forming units from stainless steel and the sample, respectively. The percentage of bacteria eliminated after 1 h corresponds to 58% of the bacteria recovered from the stainless steel coupons and the values for CH 2 mm and NCH 3 mm samples are similar.…”

Section: Resultsmentioning

confidence: 99%

Tuning the Mechanical and Antimicrobial Performance of a Cu-Based Metallic Glass Composite through Cooling Rate Control and Annealing

et al. 2017

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The influence of cooling rate on the wear and antimicrobial performance of a Cu52Z41Al7 (at. %) bulk metallic glass (BMG) composite was studied and the results compared to those of the annealed sample (850 °C for 48 h) and to pure copper. The aim of this basic research is to explore the potential use of the material in preventing the spread of infections. The cooling rate is controlled by changing the mould diameter (2 mm and 3 mm) upon suction casting and controlling the mould temperature (chiller on and off). For the highest cooling rate conditions CuZr is formed but CuZr2 starts to crystallise as the cooling rate decreases, resulting in an increase in the wear resistance and brittleness, as measured by scratch tests. A decrease in the cooling rate also increases the antimicrobial performance, as shown by different methodologies (European, American and Japanese standards). Annealing leads to the formation of new intermetallic phases (Cu10Zr7 and Cu2ZrAl) resulting in maximum scratch hardness and antimicrobial performance. However, the annealed sample corrodes during the antimicrobial tests (within 1 h of contact with broth). The antibacterial activity of copper was proved to be higher than that of any of the other materials tested but it exhibits very poor wear properties. Cu-rich BMG composites with optimised microstructure would be preferable for some applications where the durability requirements are higher than the antimicrobial needs.

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Survival rate = 1 - \frac{{CFU}_{S . Steel} - {CFU}_{Sample}}{{CFU}_{S . Steel}},

Section: Resultsmentioning

confidence: 99%

Tuning the Mechanical and Antimicrobial Performance of a Cu-Based Metallic Glass Composite through Cooling Rate Control and Annealing

et al. 2017

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“…For example, Chu et al [17] proposed the use of the Japanese Industrial Standard JIS Z2801:2000 to assess the antimicrobial properties of Zr-Cu-based thin films. The value of the antimicrobial activity proposed by this standard is calculated through the formula R = log ( B / A ) where R is the antimicrobial activity, A is the average number of viable cells of bacteria after 24 h inoculation of the treated test piece and B is the average of the number of viable cells of bacteria on the untreated test piece after 24 h. Nevertheless, the authors decided to calculate the antimicrobial rate as

\frac{N_{o} - N}{N} \times 100 %

where N 0 and N are the number of viable microbes on a control sample and on the prepared thin film respectively [17]. The same equation was used by Sharifahmadian et al to compare the antimicrobial rate of wire arc spray copper coatings with that of commercial copper and stainless steel [18].…”

Section: Standards For Antimicrobial Assessmentmentioning

confidence: 99%

“…Some authors such as Chu et al [17] used the plate count method where the number of bacterial colonies that grew on each agar plate is counted and compared to the control. Other methods are viz.…”

Section: Factors Responsible For Antimicrobial Behaviourmentioning

confidence: 99%

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Antibacterial Metallic Touch Surfaces

et al. 2016

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Our aim is to present a comprehensive review of the development of modern antibacterial metallic materials as touch surfaces in healthcare settings. Initially we compare Japanese, European and US standards for the assessment of antimicrobial activity. The variations in methodologies defined in these standards are highlighted. Our review will also cover the most relevant factors that define the antimicrobial performance of metals, namely, the effect of humidity, material geometry, chemistry, physical properties and oxidation of the material. The state of the art in contact-killing materials will be described. Finally, the effect of cleaning products, including disinfectants, on the antimicrobial performance, either by direct contact or by altering the touch surface chemistry on which the microbes attach, will be discussed. We offer our outlook, identifying research areas that require further development and an overview of potential future directions of this exciting field.

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“…Although some authors have previously studied the antimicrobial behaviour of Cucontaining metallic glasses [10,21] the possibility of tuning the antimicrobial performance by controlling the formation of crystalline phase has been mostly overlooked.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Antimicrobial and wear performance of Cu-Zr-Al metallic glass composites

et al. 2017

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The antimicrobial and wear behaviour of metallic glass composites corresponding to the Cu 50+x (Zr 44 Al 6 ) 50-x system with x=(0, 3 and 6) has been studied. The three compositions consist of crystalline phases embedded in an amorphous matrix and they exhibit crystallinity increase with increasing Cu content, i.e., decrease of the glass-forming ability. The wear resistance also increases with the addition of Cu as indirectly assessed from H/E r and H

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Antimicrobial characteristics in Cu-containing Zr-based thin film metallic glass

Cited by 50 publications

References 33 publications

Tuning the Mechanical and Antimicrobial Performance of a Cu-Based Metallic Glass Composite through Cooling Rate Control and Annealing

Tuning the Mechanical and Antimicrobial Performance of a Cu-Based Metallic Glass Composite through Cooling Rate Control and Annealing

Antibacterial Metallic Touch Surfaces

Antimicrobial and wear performance of Cu-Zr-Al metallic glass composites

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