Antimicrobial chemotherapy in the dog

English, P. B.; Prescott, C. W.

doi:10.1111/j.1748-5827.1983.tb00369.x

Cited by 6 publications

(2 citation statements)

References 87 publications

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“…In spite of the fact that the prophylactic use of antibiotics lowers the infective complication rate in certain categories of operations and in selected groups of patients, the potential harm resulting from routine antibiotic therapy cannot be ignored (English, 1983). Drug toxicity, allergic reactions and the evolution of bacterial resistance appear to be potential hazards.…”

Section: P R O P H Y L a C T I C U S E O F A N T I B I O T I C Smentioning

confidence: 99%

Antimicrobial prophylaxis in canine surgery

Bogaard¹,

Weidema

1985

J of Small Animal Practice

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In 1961, Burke showed that antibiotics affect primary wound infections favourably only if they are administered before or shortly after bacterial contamination. The effect is optimal if there is already an effective tissue concentration at the time of contamination. During surgery the animal's resistance is strongly reduced, and consequently an infection may be caused by an inoculum present in a rather low concentration, at least lower than in normal circumstances. This reduced resistance lasts until only a few hours after operation. Prophylactic use of antibiotics therefore needs to be continued only for a short time after the final stage of the operation. A great number of clinical trials in human surgery have shown that short term peri‐operative prophylactic use of antibiotics causes a reduction in the incidence of post‐operative septic complications, in certain categories of operations and in selected groups of patients. Until properly designed, prospective, randomized and controlled clinical trials have been done in small animal clinics, it seems sensible to apply the abundant results from research with experimental animals and from clinical trials in human medicine to small animal surgery. Prophylactic use of antibiotics is indicated if the infection risks or dangers of possible complications are greater than the disadvantages of regular use of antibiotics. The risk factors in the development of wound infections and the choice of antibiotics are discussed.

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Section: P R O P H Y L a C T I C U S E O F A N T I B I O T I C Smentioning

confidence: 99%

Antimicrobial prophylaxis in canine surgery

Bogaard¹,

Weidema

1985

J of Small Animal Practice

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“…Although the action of the drug on a causal organism is a prime factor in its selection for the therapy of a bacterial infection, other properties it possesses may be equally, if not more, important (Finland et al, 1976a). Such properties include: Pharmacokinetics, particularly the ability to penetrate sites of infection at inhibitory concentrations; patient tolerance or minimal untoward effect on the host tissues (English, 1983), and compatibility with other medications.…”

Section: Selection Of An Appropriate Drugmentioning

confidence: 99%

Antimicrobial chemotherapy in the dog

English

Prescott

1983

J of Small Animal Practice

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The concept is expounded that, in canine practice, antimicrobial therapy normally should be based on the pharmacology of the drug employed and the therapeutic responses that have been observed to it, as well as a knowledge of the in vitro sensitivities of causal agents. In so doing, information is presented on the concentrations of antimicrobials found to be inhibitory to micro‐organisms by in vitro tests and following clinical use. Guide‐lines to therapy are related to body systems and organs infected and to Gram‐stain reactions of isolates; also presented are dose rates, routes of administration and some general considerations employed when using the antimicrobial drugs for systemic therapy in the dog.

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Antibiotic Pressure and Nosocomial Disease

Murtaugh¹,

Mason²

1989

Veterinary Clinics of North America: Small Animal Practice

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Antimicrobial chemotherapy in the dog

Cited by 6 publications

References 87 publications

Antimicrobial prophylaxis in canine surgery

Antimicrobial prophylaxis in canine surgery

Antimicrobial chemotherapy in the dog

Antibiotic Pressure and Nosocomial Disease

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