Antimicrobial coatings based on chitosan to prevent implant-associated infections: A systematic review

Teixeira‐Santos, Rita; Lima, M. Isabel P. de; Gomes, Luciana C.; Mergulhão, Filipe

doi:10.1016/j.isci.2021.103480

Cited by 48 publications

(25 citation statements)

References 88 publications

(229 reference statements)

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“…This study also aims to investigate the antimicrobial activity of several classes of nanomaterials and structurally modified nanostructures. Organic (dendrimers [ 12 ], liposomes [ 12 ], functionalized chitosan [ 13 ]) and inorganic nanomaterials, such as surface-modified silver, gold, zinc oxide, titanium dioxide nanostructures, and copper nanocrystals, are said to have antimicrobial functionalities in biomedicine [ 9 , 11 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Modi¹,

Inwati

Gacem

et al. 2022

Antibiotics

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Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial agents, which are also known as “nanoantibiotics”. Nanomaterials have been shown to exert greater antibacterial effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants and restorative matters to prevent bacterial harm and antibacterial vaccinations to control bacterial infections are examples of nanoparticle applications in the biomedical sectors. The development of unique nanostructures, such as nanocrystals and nanostructured materials, is an exciting step in alternative efforts to manage microorganisms because these materials provide disrupted antibacterial effects, including better biocompatibility, as opposed to minor molecular antimicrobial systems, which have short-term functions and are poisonous. Although the mechanism of action of nanoparticles (NPs) is unknown, scientific suggestions include the oxidative-reductive phenomenon, reactive ionic metals, and reactive oxygen species (ROS). Many synchronized gene transformations in the same bacterial cell are essential for antibacterial resistance to emerge; thus, bacterial cells find it difficult to build resistance to nanoparticles. Therefore, nanomaterials are considered as advanced solution tools for the fields of medical science and allied health science. The current review emphasizes the importance of nanoparticles and various nanosized materials as antimicrobial agents based on their size, nature, etc.

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Section: Introductionmentioning

confidence: 99%

Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Modi¹,

Inwati

Gacem

et al. 2022

Antibiotics

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“…Besides the use of CS enabling the valorization of fish processing industry discards, CS has been widely used due to its interesting intrinsic properties including non-toxicity, biocompatibility, film-forming ability, chemical stability, low cost, and antimicrobial activity against a broad spectrum of microorganisms [ 17 ]. Although the CS mechanism of action is not entirely known, three main mechanisms have been proposed for the inhibition of microbial growth: (i) cell membrane disruption, as a result of electrostatic interactions between the positively charged CS molecules and the negatively charged cell membranes, which can lead to loss of intracellular content and cell death [ 18 , 19 ]; (ii) inhibition of protein synthesis that can occur when CS molecules penetrate microbial cells, complex with DNA and inhibit mRNA synthesis [ 20 ]; and (iii) chelation of CS molecules with some metals ions, which damages the microorganism cell wall [ 18 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Antibiofilm Performance of Chitosan-Based Surfaces in Marine Environments

Lima

Gomes

Teixeira‐Santos

et al. 2022

IJMS

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Marine biofouling is a natural process often associated with biofilm formation on submerged surfaces, creating a massive economic and ecological burden. Although several antifouling paints have been used to prevent biofouling, growing ecological concerns emphasize the need to develop new and environmentally friendly antifouling approaches such as bio-based coatings. Chitosan (CS) is a natural polymer that has been widely used due to its outstanding biological properties, including non-toxicity and antimicrobial activity. This work aims to produce and characterize poly (lactic acid) (PLA)-CS surfaces with CS of different molecular weight (Mw) at different concentrations for application in marine paints. Loligo opalescens pens, a waste from the fishery industry, were used as a CS source. The antimicrobial activity of the CS and CS-functionalized surfaces was assessed against Cobetia marina, a model proteobacterium for marine biofouling. Results demonstrate that CS targets the bacterial cell membrane, and PLA-CS surfaces were able to reduce the number of culturable cells up to 68% compared to control, with this activity dependent on CS Mw. The antifouling performance was corroborated by Optical Coherence Tomography since PLA-CS surfaces reduced the biofilm thickness by up to 36%, as well as the percentage and size of biofilm empty spaces. Overall, CS coatings showed to be a promising approach to reducing biofouling in marine environments mimicked in this work, contributing to the valorization of fishing waste and encouraging further research on this topic.

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“…Owing to its amine and hydroxyl groups, chitosan is an antioxidant agent [ 12 ]. It is also shown to be antimicrobial that makes it a great candidate for wounds and implants with a high risk of infection [ 13 , 14 , 15 , 16 ]. Chitosan can engulf proteins and polynucleotides upon electrostatic intermolecular interactions, carry them through biological barriers such as the blood–brain barrier (BBB), and sustainedly release the cargo to leave a therapeutic effect without any loss in activity [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel 3D Printing Particulate Manufacturing Technology for Encapsulation of Protein Therapeutics: Sprayed Multi Adsorbed-Droplet Reposing Technology (SMART)

et al. 2022

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Recently, various innovative technologies have been developed for the enhanced delivery of biologics as attractive formulation targets including polymeric micro and nanoparticles. Combined with personalized medicine, this area can offer a great opportunity for the improvement of therapeutics efficiency and the treatment outcome. Herein, a novel manufacturing method has been introduced to produce protein-loaded chitosan particles with controlled size. This method is based on an additive manufacturing technology that allows for the designing and production of personalized particulate based therapeutic formulations with a precise control over the shape, size, and potentially the geometry. Sprayed multi adsorbed-droplet reposing technology (SMART) consists of the high-pressure extrusion of an ink with a well determined composition using a pneumatic 3D bioprinting approach and flash freezing the extrudate at the printing bed, optionally followed by freeze drying. In the present study, we attempted to manufacture trypsin-loaded chitosan particles using SMART. The ink and products were thoroughly characterized by dynamic light scattering, rheometer, Scanning Electron Microscopy (SEM), and Fourier Transform Infra-Red (FTIR) and Circular Dichroism (CD) spectroscopy. These characterizations confirmed the shape morphology as well as the protein integrity over the process. Further, the effect of various factors on the production were investigated. Our results showed that the concentration of the carrier, chitosan, and the lyoprotectant concentration as well as the extrusion pressure have a significant effect on the particle size. According to CD spectra, SMART ensured Trypsin’s secondary structure remained intact regardless of the ink composition and pressure. However, our study revealed that the presence of 5% (w/v) lyoprotectant is essential to maintain the trypsin’s proteolytic activity. This study demonstrates, for the first time, the viability of SMART as a single-step efficient process to produce biologics-based stable formulations with a precise control over the particulate morphology which can further be expanded across numerous therapeutic modalities including vaccines and cell/gene therapies.

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Antimicrobial coatings based on chitosan to prevent implant-associated infections: A systematic review

Cited by 48 publications

References 88 publications

Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Assessment of the Antibiofilm Performance of Chitosan-Based Surfaces in Marine Environments

A Novel 3D Printing Particulate Manufacturing Technology for Encapsulation of Protein Therapeutics: Sprayed Multi Adsorbed-Droplet Reposing Technology (SMART)

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