Antimicrobial Compounds from Terminalia brownii against Sweet Potato Pathogens

Opiyo, Sylvia A.; Manguro, Lawrence Onyango Arot; Owuor, P.O.; Ochieng, Charles O.; Ateka, Elijah; Lemmen, Peter

doi:10.2174/2210315511101020116

Cited by 11 publications

(23 citation statements)

References 17 publications

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“…1 Terminalia brownii is used traditionally as a remedy for various conditions such as malaria, yellow fever, diarrhea, ulcers, cough, hepatitis, stomach ache, and sexually transmitted diseases. [8][9][10] In addition, Terminalia brownii has been found to have antioxidant activities and hepatoprotective properties. 11 Previous studies on the plant reported the antimicrobial activity of its extracts and fractions.…”

Section: Discussionmentioning

confidence: 99%

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Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis)

2018

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Taking scented smoke baths (Dukhan) is a universal custom among African women who indulge in it for pleasure, cleanliness, health, and for restoration after childbirth. The woods used in this procedure are usually Acacia seyal and Terminalia brownii. This report is a case series of 11 women with brown-erythematous excoriated papules, plaques, and lichenification confined to the sites of scented smoke baths. They were diagnosed with airborne contact dermatitis on the basis of patient history, existence of dust agents, the morphology and distribution of the lesions, the results of epicutaneous tests (repeated open application test), and avoidance of further exposure leading to recovery from dermatitis.

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Section: Discussionmentioning

confidence: 99%

“…Terminalia brownii is known with its antibacterial and antioxidant properties, and the use of smoke from Acacia seyal is associated with an increased risk of visceral leishmaniasis (phlebotomus make peak activities in thickets of Acacia seyal). [3][4][5][6][7][8][9][10][11][12][13]…”

Section: Introductionmentioning

confidence: 99%

Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis)

2018

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“…Investigations on the phytochemical constituents of T. brownii are scanty. The pentacyclic triterpenoids arjungenin and betulinic acid as well as β-sitosterol and ellagic acid derivatives have been characterized from the leaves and stem bark [36,37,38]. Of these compounds, arjungenin, betulinic acid and β-sitosterol showed good growth inhibitory activity against sweet potato fungal pathogens such as Aspergillus niger, Fusarium solanii and Fusarium oxysporum [38].…”

Section: Introductionmentioning

confidence: 99%

“…The pentacyclic triterpenoids arjungenin and betulinic acid as well as β-sitosterol and ellagic acid derivatives have been characterized from the leaves and stem bark [36,37,38]. Of these compounds, arjungenin, betulinic acid and β-sitosterol showed good growth inhibitory activity against sweet potato fungal pathogens such as Aspergillus niger, Fusarium solanii and Fusarium oxysporum [38]. In addition, a number of known and unknown ellagitannins as well a chromone derivative have been characterized in T. brownii [36,39,40].…”

Section: Introductionmentioning

confidence: 99%

“…Although T. brownii extracts are used traditionally against fungal phytopathogens and for human fungal infections in Sudan, there is a limited number of reports on their in vitro antifungal activity against molds affecting crop production and human health. Moreover, only a small number of antifungal compounds in T. brownii have been characterized to date [37,38]. Therefore, the current study was performed to verify the antifungal effects of decoctions and macerations and to compare the antifungal activity of T. brownii extracts of various polarities against significant phytopathogenic and human pathogenic opportunistic fungi of the genera Aspergillus, Nattrassia and Fusarium.…”

Section: Introductionmentioning

confidence: 99%

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LC-MS/MS Tandem Mass Spectrometry for Analysis of Phenolic Compounds and Pentacyclic Triterpenes in Antifungal Extracts of <em>Terminalia brownii</em> (Fresen)

Salih

Fyhrquist

Abdalla

et al. 2017

Preprint

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Decoctions, macerations and fumigations of the stem bark and wood of Terminalia brownii Fresen. are used in traditional medicine for fungal infections and as pesticides on field crops and in traditional granaries in Sudan. In addition, T. brownii is commonly used for protecting wooden houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts of various polarities from the stem wood and bark were screened for their growth inhibitory effects against filamentous fungi commonly causing fruit, vegetable and grain decay, as well as infections in the immunocompromised host. Ethyl acetate extracts of the stem wood and bark gave the best antifungal activities, with MIC values of 250 µg/ml against Nattrassia mangiferae and Fusarium verticillioides, and 500 µg/ml against Aspergillus niger and Aspergillus flavus. Aqueous extracts gave almost as potent effects as the ethyl acetate extracts against the Aspergillus and Fusarium strains, and were slightly more active than the ethyl acetate extracts against Nattrassia mangiferae. Thin layer chromatography, RP-HPLC-DAD and tandem mass spectrometry (LC-MS/MS), were employed to identify the chemical constituents in the ethyl acetate fractions of the stem bark and wood. The stem bark and wood were found to have a similar qualitative composition of polyphenols and triterpenoids, but differed quantitatively from each other. The stilbene derivatives, cis- (3) and trans- (4) resveratrol-3-O-β-galloylglucoside, were identified for the first time in T. brownii. Moreover, methyl-(S)-flavogallonate (5), quercetin-7-β-O-di-glucoside (8), quercetin-7-O-galloyl-glucoside (10), naringenin-4`-methoxy-7-pyranoside (7), 5,6-dihydroxy-3`,4`,7-tri-methoxy flavone (12), gallagic acid dilactone (terminalin) (6), a corilagin derivative (9) and two oleanane type triterpenoids (1) and (2) were characterized. Our results justify the traditional uses of macerations and decoctions of T. brownii stem wood and bark for crop and wood protection and demonstrate that standardized extracts could have uses for the eco-friendly control of plant pathogenic fungi in African agroforestry systems. Likewise, our results justify the traditional uses of these preparations for the treatment of skin infections caused by filamentous fungi.

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The Genus Terminalia (Combretaceae): An Ethnopharmacological, Phytochemical and Pharmacological Review

Zhang

Kaunda

Zhu

et al. 2019

Nat. Prod. Bioprospect.

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Terminalia Linn, a genus of mostly medium or large trees in the family Combretaceae with about 250 species in the world, is distributed mainly in southern Asia, Himalayas, Madagascar, Australia, and the tropical and subtropical regions of Africa. Many species are used widely in many traditional medicinal systems, e.g., traditional Chinese medicine, Tibetan medicine, and Indian Ayurvedic medicine practices. So far, about 39 species have been phytochemically studied, which led to the identification of 368 compounds, including terpenoids, tannins, flavonoids, phenylpropanoids, simple phenolics and so on. Some of the isolates showed various bioactivities, in vitro or in vivo, such as antitumor, anti HIV-1, antifungal, antimicrobial, antimalarial, antioxidant, diarrhea and analgesic. This review covers research articles from 1934 to 2018, retrieved from SciFinder, Wikipedia, Google Scholar, Chinese Knowledge Network and Baidu Scholar by using “Terminalia” as the search term (“all fields”) with no specific time frame setting for the search. Thirty-nine important medicinal and edible Terminalia species were selected and summarized on their geographical distribution, traditional uses, phytochemistry and related pharmacological activities.

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Antimicrobial Compounds from Terminalia brownii against Sweet Potato Pathogens

Cited by 11 publications

References 17 publications

Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis)

Acacia seyal and Terminalia brownii associated airborne contact dermatitis (Dukhan dermatitis)

LC-MS/MS Tandem Mass Spectrometry for Analysis of Phenolic Compounds and Pentacyclic Triterpenes in Antifungal Extracts of <em>Terminalia brownii</em> (Fresen)

The Genus Terminalia (Combretaceae): An Ethnopharmacological, Phytochemical and Pharmacological Review

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