Antimicrobial Dosing Error in Intermittent & Continuous Hemodialysis

Abstract

Antibiotic drugs are the most frequently prescribed medications among hospitalized patients for life-saving purposes, mainly in immunocompromised patient, like in patient with end stage renal disease on hemodialysis (HD) or those who had documented bacterial infection. Antibiotics disposition and their pharmacokinetics and pharmacodynamics properties are affected in hemodialysis patient which increases the number of antibiotics dosing errors. Several epidemiological studies found that the majority of medication error related to antibiotics occurred during the prescribing phase (30.8%). However, there is missing data about the prevalence of errors in antibiotics dosing in HD patients.