2017
DOI: 10.1080/17512433.2017.1279968
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Antimicrobial dosing in neonates

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Cited by 9 publications
(10 citation statements)
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“…A registry-based population study from Norway (2009–2011) showed that half of term-infants receiving antibiotics were not proven to have a bacterial infection (11). Use of BSA in Norwegian neonates is lower than in older children, but empirical choices of antibiotics vary, and there is a lack of evidence on neonatal dose regimes (15, 16).…”
Section: Introductionmentioning
confidence: 99%
“…A registry-based population study from Norway (2009–2011) showed that half of term-infants receiving antibiotics were not proven to have a bacterial infection (11). Use of BSA in Norwegian neonates is lower than in older children, but empirical choices of antibiotics vary, and there is a lack of evidence on neonatal dose regimes (15, 16).…”
Section: Introductionmentioning
confidence: 99%
“… 28 , 29 This is suboptimal, as infants display distinctly different pharmacokinetics (PK) that vary based on gestational and postnatal age. 30 Under-dosing of antibiotics leads to ineffective treatment of infection and promotes the development of microbial resistance, whereas over-dosing results in toxicity and compromised safety. 31 Multiple PK studies of antibiotics have been performed in infants to define dosing that optimizes therapeutic exposures for infants ( Table 1 ).…”
Section: Antibiotic Use In the Neonatal Intensive Care Unit (Nicu)mentioning
confidence: 99%
“…A registry-based population study from Norway (2009)(2010)(2011) showed that half of term-infants receiving antibiotics were not proven to have a bacterial infection (11). Use of BSA in Norwegian neonates is lower than in older children, but empirical choices of antibiotics vary, and there is a lack of evidence on neonatal dose regimes (15,16).…”
Section: Introductionmentioning
confidence: 99%