Antimicrobial Effect of Silver-Coated External Fixator Pins

Meyer, C; Kessler, James C.; Alt, Volker; Wenisch, Sabine; Hartmann, Bojan; Schiefer, Hans Gerd; Schnettler, Reinhard

doi:10.1055/s-2004-822684

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…[50,51] In recent research, different methods were used for coating external fixators for improving their biomedical treatment. [52] Using the coating methods on the implant pins' surface began in 1913 via Lambotte et al [53] Applying the coating methods confirmed the reduction of infections after coating the surface of the pin, but mechanical loosening was still observed. [52] Nowadays, medical researchers find that HA can improve osteointegration and the stability of the external fixator pins interface.…”

Section: Ha Structurementioning

confidence: 99%

Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Nakhaei

Jirofti

Ebrahimzadeh

et al. 2023

Plasma Processes & Polymers

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Section: Ha Structurementioning

confidence: 99%

Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Nakhaei

Jirofti

Ebrahimzadeh

et al. 2023

Plasma Processes & Polymers

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Treatment of Infected Nonunions: Techniques Other Than Compression-Distraction Methods

Pedrotti

Mora

Bertani

Nonunion of the Long Bones

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Antimicrobial Efficacy of Surface-Coated External Fixation Pins

et al. 2011

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In clinical applications, colonization of metal implants by adhesive and biofilm-forming bacteria not only prolong healing but create additional healthcare costs for implant revision and antimicrobial treatment. An in vitro assay was established investigating the antimicrobial surface activity of external fixation pins intended for use in bone fractures and deformities. Test articles made out of stainless steel and coated with a polymer-containing nanoparticulate silver were compared to non-coated reference controls out of stainless steel, copper and titanium. Staphylococcus epidermidis, known as a predominant cause for implant-related infections was used as test organism. Test pins and bacteria were incubated for a period of 20 h found to be sufficient for initiating biofilm formation. After removing non- and low-adherent bacteria by rinsing, two methods were used to isolate high-adherent (sessile) bacteria from the implant surfaces. Besides shaking the implants in a solution containing small glass beads, a cytobrush technique was used to mechanically harvest viable bacteria. Finally, the amount of detached bacteria was determined by plate counts. Several parameters identified to be critical within the different removal procedures such as the inoculum concentration and the shaking time in the presence of glass beads as well as time of the cytobrush treatment were analysed. The final test scheme resulted in the use of an inoculum of 10(5) colony forming units (CFU) per millilitre, ten rinsing steps for the removal of low adherent bacteria and 5 min of shaking in the presence of glass beads, detaching the high-adherent bacteria. Due to subjective variations impacting the outcome of the procedure, the cytobrush technique was not favoured and finally rejected. Using the in vitro assay developed, it could be demonstrated that fixation pins coated with silver show a 3 log step reduction in the number of biofilm-forming bacteria compared to a non-coated stainless steel or titanium implant. Pins made out of copper showed the highest antimicrobial efficacy, as the number of detached bacteria was found to be below the detection limit, they served as a positive control within this test.

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Antimicrobial Effect of Silver-Coated External Fixator Pins

Cited by 4 publications

References 12 publications

Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Treatment of Infected Nonunions: Techniques Other Than Compression-Distraction Methods

Antimicrobial Efficacy of Surface-Coated External Fixation Pins

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