Antimicrobial Peptides, a Pool for Novel Cell Penetrating Peptides Development and Vice Versa

Nooranian, Samin; Oskuee, Reza Kazemi; Jalili, Amin

doi:10.1007/s10989-021-10161-8

Cited by 7 publications

(2 citation statements)

References 67 publications

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“…This particular class of bioactive peptides is also called antimicrobial and cell-penetrating peptides (ACPPs) [ 37 ]. Antimicrobial peptides that penetrate the target cells without causing membrane disruption exert their biocide effects intracellularly figure in the subset of CPAPs [ 38 , 39 ]. CPPs that intrinsically translocate eukaryotic cell membranes and cross the cytoplasmic membrane of bacteria can kill pathogens by distributing and accumulating within the vacuolar compartments of cells, as is the case of penetratin analogs [ 40 ].…”

Section: Peptides With Cell-penetrating and Anti-infective Activity A...mentioning

confidence: 99%

Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens

et al. 2022

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Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is often limited. In addition to this primordial activity of cell penetration without membrane disruption, multivalent antimicrobial activity accompanies some CPPs. Antimicrobial peptides (AMPs) with cell-penetrability exert their effect intracellularly, and they are of great interest. CPPs with antimicrobial activity (CPAPs) comprise a particular class of bioactive peptides that arise as promising agents against difficult-to-treat intracellular infections. This short review aims to present the antibacterial, antiparasitic, and antiviral effects of various cell-penetrating antimicrobial peptides currently documented. Examples include the antimicrobial effects of different CPAPs against bacteria that can propagate intracellularly, like Staphylococcus sp., Streptococcus sp., Chlamydia trachomatis, Escherichia coli, Mycobacterium sp., Listeria sp., Salmonella sp. among others. CPAPs with antiviral effects that interfere with the intracellular replication of HIV, hepatitis B, HPV, and herpes virus. Additionally, CPAPs with activity against protozoa of the genera Leishmania, Trypanosoma, and Plasmodium, the etiological agents of Leishmaniasis, Chagas’ Disease, and Malaria, respectively. The information provided in this review emphasizes the potential of multivalent CPAPs, with anti-infective properties for application against various intracellular infections. So far, CPAPs bear a promise of druggability for the translational medical use of CPPs alone or in combination with chemotherapeutics. Moreover, CPAPs could be an exciting alternative for pharmaceutical design and treating intracellular infectious diseases.

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Section: Peptides With Cell-penetrating and Anti-infective Activity A...mentioning

confidence: 99%

Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens

et al. 2022

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“…Derived from the Antennapedia homeodomain from Drosophila, Antennapedia peptide is a 16-residue peptide [RQIKIWFQNRRMKWKK (43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)] employed as a vector for the cellular uptake of hydrophilic molecules [21,24,25]. Further results demonstrated that among all tested peptides, Antennapedia peptide is a promising antibacterial peptide with high selectivity and less cytotoxicity for mammalian cells that could be further applied as a delivery system for antibacterial agent delivery [26,27].…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Antimicrobial Properties of Peptides through Cell-Penetrating Peptide Conjugation: A Comprehensive Assessment

Kravchenko,

Domnin,

Grishin

et al. 2023

IJMS

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Combining antimicrobial peptides (AMPs) with cell-penetrating peptides (CPPs) has shown promise in boosting antimicrobial potency, especially against Gram-negative bacteria. We examined the CPP-AMP interaction with distinct bacterial types based on cell wall differences. Our investigation focused on AMPs incorporating penetratin CPP and dihybrid peptides containing both cell-penetrating TAT protein fragments from the human immunodeficiency virus and Antennapedia peptide (Antp). Assessment of the peptides TAT-AMP, AMP-Antp, and TAT-AMP-Antp revealed their potential against Gram-positive strains (Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), and Bacillus cereus). Peptides TAT-AMP and AMP-Antp using an amyloidogenic AMP from S1 ribosomal protein Thermus thermophilus, at concentrations ranging from 3 to 12 μM, exhibited enhanced antimicrobial activity against B. cereus. TAT-AMP and TAT-AMP-Antp, using an amyloidogenic AMP from the S1 ribosomal protein Pseudomonas aeruginosa, at a concentration of 12 µM, demonstrated potent antimicrobial activity against S. aureus and MRSA. Notably, the TAT-AMP, at a concentration of 12 µM, effectively inhibited Escherichia coli (E. coli) growth and displayed antimicrobial effects similar to gentamicin after 15 h of incubation. Peptide characteristics determined antimicrobial activity against diverse strains. The study highlights the intricate relationship between peptide properties and antimicrobial potential. Mechanisms of AMP action are closely tied to bacterial cell wall attributes. Peptides with the TAT fragment exhibited enhanced antimicrobial activity against S. aureus, MRSA, and P. aeruginosa. Peptides containing only the Antp fragment displayed lower activity. None of the investigated peptides demonstrated cytotoxic or cytostatic effects on either BT-474 cells or human skin fibroblasts. In conclusion, CPP-AMPs offer promise against various bacterial strains, offering insights for targeted antimicrobial development.

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Brevinin-2R: Antimicrobial Peptide with Cytotoxic and Apoptogenic Activity Against Daunorubicin Resistant Gastric Cancer Cells

et al. 2023

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Antimicrobial Peptides, a Pool for Novel Cell Penetrating Peptides Development and Vice Versa

Cited by 7 publications

References 67 publications

Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens

Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens

Enhancing the Antimicrobial Properties of Peptides through Cell-Penetrating Peptide Conjugation: A Comprehensive Assessment

Brevinin-2R: Antimicrobial Peptide with Cytotoxic and Apoptogenic Activity Against Daunorubicin Resistant Gastric Cancer Cells

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