Antimicrobial Polymeric Structures Assembled on Surfaces

Abstract

Pathogenic microbes are the main cause of various undesired infections in living organisms, including humans. Most of these infections are favored in hospital environments where humans are being treated with antibiotics and where some microbes succeed in developing resistance to such drugs. As a consequence, our society is currently researching for alternative, yet more efficient antimicrobial solutions. Certain natural and synthetic polymers are versatile materials that have already proved themselves to be highly suitable for the development of the next-generation of antimicrobial systems that can efficiently prevent and kill microbes in various environments. Here, we discuss the latest developments of polymeric structures, exhibiting (reinforced) antimicrobial attributes that can be assembled on surfaces and coatings either from synthetic polymers displaying antiadhesive and/or antimicrobial properties or from blends and nanocomposites based on such polymers.

Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success

“…They provide ideal surfaces that can improve the long-term performance and stability of devices/implants. Various polymeric brushes have been designed on multiple substrates during the last decades [170][171][172][173], and here, we feature some examples of the supramolecular assemblies of polymer brushes with HDPs.…”

Strategies for Prevention and Control of Multidrug-resistant Bacteria in Ruminants

“…In addition, be effective for prevention and treatment against multidrug-resistant (MDR) bacterial pathogens (Ali and Dixit, 2012) Alternatives strategies for prevention and control of MDR bacteria in ruminants include antibiotics for growth promotion (such as in-feed enzymes, probiotics, prebiotics and synbiotics, and antimicrobial peptides), alternatives to antibiotics for disease prevention (such as vaccines, immune modulators, chicken egg yolk antibodies, farm management, and biosecurity), alternatives to antibiotics for disease treatment (such as phytochemicals plant extracts and phage-therapy), and other alternatives for disease prevention include Nanoparticles (NPs) (Alwhibi and Soliman, 2014). Alternative methods may reduce antibiotic resistance but could not be a substitution for antibiotics (Aizawa et al, 20016;Babutan et al, 2021).…”

Degradable, biocompatible, and antibacterial polygalacturonic acid/polyethyleneimine polyplex particles

“…The spread and growth of infections is an important health problem, as they cause many diseases directly or indirectly. These bacterial, fungal, or viral pathogens could be colonized on many different surfaces such as surgical equipment, medical devices, hospital, or public surfaces 1 as well as various industrial products, including textile, food, oral, dental, cosmetic, and health care products 2,3 . There is increasing interest in the design of new antimicrobial materials to stop the rapid spread of these harmful organisms 4 .…”