Antimicrobial Polymers with Metal Nanoparticles

Palza, Humberto

doi:10.3390/ijms16012099

Cited by 639 publications

(394 citation statements)

References 74 publications

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“…Palza [20] reviewed a number of polymer hybrids containing various amounts of Ag or Cu nano-or microparticles suggesting that these systems could be useful as biocide materials for medical applications. Among them, a PA6-based hybrid containing 2 wt% of Ag nanoparticles obtained in-situ from silver acetate during the sample melt processing was found to be extremely effective against Escherichia coli during a long period of time, while the pure PA6 did not show any antimicrobial efficacy [21].…”

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confidence: 99%

Preparation and properties of metal-containing polyamide hybrid composites via reactive microencapsulation

et al. 2016

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Polyamide 6 microcapsules (PAMC) loaded with 2-8 wt% of Cu, Zn or Fe and up to 30 wt% of Al particles are synthesized via activated anionic polymerization (AAP) of ε-caprolactam in suspension performed in the presence of the respective micro-or nanosized loads. The highmolecular weight porous PAMC are with typical diameters of 10-90 µm depending on the size of the metal filler particles. The latter are entrapped in the core of PAMC as proven by microscopy methods. The melt processing of the loaded microcapsules produced PA6/metal hybrid thermoplastic composites with homogeneous distribution of the loads without any functionalization. The crystalline structure of all PAMC and molded composites are studied by thermal and microfocus X-ray diffraction methods suggesting polymorph changes during the transition from PAMC to molded plates. Mechanical tests in tension showed that transforming Al-loaded PAMC into composites produces polyamide hybrids with higher modulus and strength at break. Measuring the conductivity and dielectric properties of the composites in linear and cyclic modes showed that 30 wt% of Al can change significantly the permittivity of the hybrid composites without increasing the conductivity of the PA6 matrix.

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Preparation and properties of metal-containing polyamide hybrid composites via reactive microencapsulation

et al. 2016

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“…gonorrohea, P. mirabilis, Klebsiella, Streptococcus mutans, Vibrio cholerae, E. coli, C. freundii and on fungi like A. nidulans, A. flavus. A spergillus niger and R. stolonifer is reported in the literature by the researchers [23][24][25][26][27][28]. Silver NPs are found to be very toxic to several bacteria.…”

Section: Mechanism Of Nps-microorganism Interaction and Impact On Biomentioning

confidence: 99%

Effect of Nanoparticles on Biodiversity of Soil and Water Microorganism Community

Samanta¹,

Mandal²

2017

J Tissue Sci Eng

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Nanostructured materials are in the frontline of the present scientific research because of their multifunctional properties that leads their applications from optics to electronic, from mechanical engineering to medical science and technology. However increased levels of nanomaterials in the environment drastically affect the lifestyle activity of the microorganism of the environment. This also changes the biodiversity of the system. This mini review discusses about effect of nanoparticles on the Biodiversity of Soil and Water Microorganism Community as reported by the researchers. Also the mechanism of nanoparticle-microorganism interaction and functionality has been discussed.

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“…Passive targeting is based on particle size and the ability of PNPs to form pores, which disrupt the structure of the pathogen membrane [23,36,37]. Recent studies indicate that conjugation of lectin-specific ligands on the PNP surface showed enhanced binding affinity to the carbohydrate receptors on the Helicobacter pylori membrane [38].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…RAFT [13]. In addition, polymeric nanoparticles may also be used as a reaction or dispersion medium for the synthesis of nanoparticles [23]. Regardless of the synthesis method used, PNPs that are prepared for biomedical applications should be completely free from unreacted reagents, organic solvents, surfactants or traces of heavy metals or catalysts [24,25].…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Michalak¹,

Głuszek²,

Piktel³

et al. 2016

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The increased prevalence of antibiotic-resistant pathogens requires additional efforts to develop new antimicrobial agents and alternative methods to prevent and treat infections. In response to this challenge, a variety of nanotechnology-based tools are currently being designed and thoroughly investigated. To date, a considerable number of studies have reported increased activity of antibiotic-conjugated polymeric nanoparticles against bacteria and fungi associated with various infections, including those caused by drug-resistant pathogens. Importantly, high biocompatibility of these structures coupled with enhanced biological activity and improved pharmacokinetic properties supports the potential of these nanosystems as new tools to treat infections. In this review, we summarize the synthesis of polymer-based nanoparticles and describe their mechanism of action. We also highlight the recent advances in the application of antibiotic-conjugated polymeric nanoparticles as novel antimicrobial agents. StreszczenieStale narastająca lekooporność drobnoustrojów wymusza konieczność rozwoju alternatywnych metod profilaktyki i terapii zakażeń, a także uzasadnia prace nad nowymi lekami o aktywności przeciwdrobnoustrojowej. Realizacja tego celu jest moż-liwa dzięki zastosowaniu osiągnięć z zakresu nanotechnologii. Zwiększająca się liczba doniesień literaturowych potwierdza znaczną aktywność przeciwdrobnoustrojową nanocząstek polimerowych skoniugowanych z klasycznymi antybiotykami, co może zostać wykorzystane w terapii infekcji o charakterze bakteryjnym i grzybiczym, również tych wywoływanych przez patogeny lekooporne. Wysoka biokompatybilność nanocząstek polimerowych, a także możliwość zwiększania aktywności przeciwdrobnoustrojowej i poprawy parametrów farmakokinetycznych stosowanych obecnie chemioterapeutyków, wskazuje na możliwość zastosowania nanostruktur w nowoczesnej terapii chorób infekcyjnych. W niniejszej pracy podsumowano metody syntezy nanosystemów opartych na nanocząstkach polimerowych, a także opisano mechanizm ich działania. Przedstawione zostały również najnowsze osiągnięcia w syntezie nanocząstek skoniugowanych z antybiotykami, pozwalające na ich zastosowanie w terapii infekcji o charakterze bakteryjnym i grzybiczym.

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Antimicrobial Polymers with Metal Nanoparticles

Cited by 639 publications

References 74 publications

Preparation and properties of metal-containing polyamide hybrid composites via reactive microencapsulation

Preparation and properties of metal-containing polyamide hybrid composites via reactive microencapsulation

Effect of Nanoparticles on Biodiversity of Soil and Water Microorganism Community

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

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