Antimicrobial Potential of Naturally Occurring Bioactive Secondary Metabolites

Abstract

The use of traditional medicines of natural origin has been prevalent since ancient times globally as the plants produce a great diversity in their secondary metabolites. The naturally occurring bioactive constituents in food and other plant materials have shown widespread attention for their use as alternative medicine to prevent and cure microbial growth with the least toxic manifestations. The inclusion of these contents revealed their crucial role to improve the therapeutic efficacy of the classical drugs against various pathogenic microorganisms. Furthermore, several metabolites have also been explored in combination with antimicrobial agents to overcome the problems associated with drug resistance. This current review discusses the antimicrobial activities of secondary metabolites as well as their role in drug sensitivity against multiple-drug resistant pathogenic microbes.

Antibacterial activity of freshwater green microalgae from Almaty region

“…The result of the GC/MS study shown in Table 3 revealed the presence of several important compounds, highlighting the detection of specific phenols, alkaloids, terpenes and esters with antibacterial properties [26]. In particular, cyclotrisiloxane-hexamethyl and cyclotetrasiloxane-octamethyl were identified as the predominant compounds in the strains studied, with a particular content in P. kessleri.…”

Enhancing Commercial Antibiotics with Trans-Cinnamaldehyde in Gram-Positive and Gram-Negative Bacteria: An In Vitro Approach

“…Therefore, the search for new antimicrobial natural products continues to draw the attention of many researchers. One of the most influential families of bioactive phytochemicals are polyphenols, which, alongside terpenes, are one of the most abundant groups of secondary metabolites [ 8 ]. The chemical structure of polyphenols includes one hydroxyl group (-OH), responsible not only for the antioxidant properties but also for the antimicrobial ones.…”

Enhanced Antimicrobial Activity through Synergistic Effects of Cold Atmospheric Plasma and Plant Secondary Metabolites: Opportunities and Challenges

“…Plant secondary metabolites (PSMs), which are biologically active compounds produced by plants, have gained attention as alternative therapies for various medical conditions [7,8]. These compounds have been shown to have a wide range of pharmacological activities, including anti-inflammatory, antioxidant, and antimicrobial properties [9,10]. They are often used in traditional medicine and are being studied for their potential to treat a variety of health problems, such as infections, inflammation, cancer, and cardiovascular disease [11].…”