Antimicrobial regional limb perfusion in horses

Rubio‐Martínez, Luis M.; Cruz, Antonio

doi:10.2460/javma.228.5.706

Cited by 96 publications

(153 citation statements)

References 41 publications

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“…The median (range) age at the time of admission was 4 years (0.003 to 20 years). Athletic use at the time of admission was recorded in 150 (86.21%) cases and included racing (n = 60), performance (showjumping, dressage, or western showing; 32), pleasure riding (13), breeding (8), and other purposes (2). There were 5 yearlings or young horses that had not started training and 30 foals (age ≤ 6 months).…”

Section: Resultsmentioning

confidence: 99%

“…There were 5 yearlings or young horses that had not started training and 30 foals (age ≤ 6 months). There were 96 horses with septic synovitis (group 1; 74 septic joints, 16 septic sheaths, and 6 septic bursae), 50 with lacerations (group 2; 27 fresh, minimally contaminated intrasynovial lacerations and 23 extrasynovial lacerations), and 28 with other conditions (group 3; osteomyelitis [4], fractures [2], prophylactic use of A-RLP [11], surgical site infections [5], and other conditions [6]). Median (range) duration prior to admission to the hospital was 4 days (0 to 60 days; group 1), 0 days (0 to 25 days; group 2), and 5 days (0 to 180 days; group 3).…”

Section: Resultsmentioning

confidence: 99%

“…Antimicrobial doses varied widely, which is commonly observed in the literature. 2,5,11,12,25 Regional limb perfusion with antimicrobials was repeated on a daily basis, although longer intervals (36 hours) have been indicated on the basis of studies 22 performed on healthy horses. However, amikacin clearance was shortened in inflamed versus normal joints, 26 and the septic acidic environment and accumulated cellular debris decrease the activity of some antimicrobials.…”

Section: Discussionmentioning

confidence: 99%

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Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999–2009)

Rubio‐Martínez

Elmas²,

Black³

et al. 2012

javma

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Objective—To describe the clinical use of regional limb perfusion with antimicrobials (A-RLP), complications, and outcome in a large series of patients. Design—Retrospective case series. Animals—174 horses. Procedures—Medical records of horses treated with A-RLP between 1999 and 2009 were reviewed. Signalment, primary complaint, horse use, etiology, duration of clinical signs, previous treatment, structures involved, concurrent conditions, A-RLP characteristics, additional treatments, complications, and outcome were recorded. At long-term follow-up, 2 outcomes were investigated: survival rate and return to previous use at the same or higher level. Univariate and multivariate logistic regression analyses were conducted. Results—Group 1 (96 horses) included septic synovitis. Group 2 (50 horses) included extrasynovial lacerations (23 horses) and fresh, minimally contaminated intrasynovial lacerations without evidence of established synovial infection (27 horses). Group 3 (28 horses) included miscellaneous other conditions. Only minor complications were reported in 12.26% of horses that received IV (n = 155) and 33% of horses that received intraosseous (27) A-RLP. Horses with septic synovitis had a lower survival rate (53.43%) than did horses with lacerations (91.89%). Within group 2, no significant differences in short- or long-term outcomes were found between horses with extrasynovial and fresh, minimally contaminated intrasynovial lacerations. For the horses returning to previous use, 80% of horses with septic synovitis and 72.72% of horses with lacerations were performing at the same or higher level at the time of follow-up. Conclusions and Clinical Relevance—The results of the present study indicated that A-RLP is a safe technique with minimal adverse effects. The IV route presented fewer complications than intraosseous injection. Horses with infection of synovial structures had a lower survival rate than did those with acute, minimally contaminated intrasynovial lacerations. The latter had a similar prognosis for horses with extrasynovial lacerations treated with A-RLP.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999–2009)

Rubio‐Martínez

Elmas²,

Black³

et al. 2012

javma

Self Cite

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“…Λέξεις ευρετηρίασης: άρδευση του περιφερικού άκρου, αμικακίνη, ίππος ΕΙΣΑΓΩΓΗ Η άρδευση του περιφερικού τμήματος του άκρου (Distal Limb Perfusion -DLP) ορίζεται ως η δια δικασία της χορήγησης μίας φαρμακευτικής ουσίας σε μία συγκεκριμένη περιοχή αυτού που έχει απομονωθεί από τη συστηματική κυκλοφορία μέσω της εφαρμογής προσωρινής ίσχαιμης περίδεσης κεντρικά (Rubio-Martinez and Cruz 2006). Είναι μία μέθοδος έμμεσης παρο χής φαρμακευτικών ουσιών που βασίζεται αποκλειστικά στην αιματική και λεμφική κυκλοφορία για τη διανομή της ουσίας στον ιστό στόχο (Errico et al 2008).…”

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“…Μετά την τοποθέτηση ίσχαι-μης περίδεσης κεντρικά, και προκειμένου για την εν δοφλέβια και ενδοαρτηριακή οδό, γίνεται έγχυση δια λύματος της αντιμικροβιακής ουσίας σε μία καθετη ριασμένη φλέβα ή αρτηρία, αντίστοιχα. Στην περίπτω ση της ενδοστικής οδού η χορήγηση γίνεται απευθείας ενδομυελικώς (Rubio-Martinez and Cruz 2006). Η DLP χρησιμοποιείται για την επίτευξη υψηλών συγκεντρώσεων μιας αντιμικροβιακής ουσίας σε έν τονα σηπτικές καταστάσεις με παράλληλη μείωση των ανεπιθύμητων συστηματικών παρενεργειών (Errico et al 2008).…”

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Distal limb perfusion with amikacin in two horses

Zamboulis

Diakakis

2018

J Hellenic Vet Med Soc

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Distal Limb Perfusion (DLP) involves the administration of a drug into the vasculature of a selected portion of thelimb that has been isolated from the systemic circulation by the application of a tourniquet (Rubio-Martinez and Cruz 2006). It is used to achieve high tissue concentrations of an antimicrobial in septic sites, while reducing undesirable systemic effects (Errico et al. 2008). DLP has been used as an adjunctive therapy in the treatment of sepsis improving greatly the outcome (Kramer 2006). In the present study, two cases of elimination of musculoskeletal sepsis are being presented. The first case is about a horse with chronic, partial hoof avulsion injury and infection of soft tissues. The second case is about a foal that presented with osteomyelitis of the third metatarsus bone. Both cases where treated with surgical debridment of the affected areas in conjuction with DLP and systemic therapy. For the first case, DLP targeted the hoof and it was performed through the lateral palmar digital vein with a solution of 125 mg of amikacin (Briklin®, Bristol-Myers Squibb) in 30 mL of 0,9% NaCl solution. For the second case, DLP targeted the metatarsus and it was performed through the medial saphenous vein with a solution of 250 mg of amikacin (Briklin®, Bristol-Myers Squibb) in 60 mL of 0,9% NaCl solution. The outcome of both patients was good despite their bad prognosis. DLP is a simple and effective method for treatment of septic conditions of the horse's distal limb, which is nowadays growing in popularity with promising results.

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Diagnosis and Management of Wounds Involving Synovial Structures

Seabaugh¹,

Baxter²

2016

Equine Wound Management

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Antimicrobial regional limb perfusion in horses

Cited by 96 publications

References 41 publications

Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999–2009)

Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999–2009)

Distal limb perfusion with amikacin in two horses

Diagnosis and Management of Wounds Involving Synovial Structures

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