Antimicrobial resistance and epidemiology of<i>Escherichia coli</i>in broiler breeder chickens

Ginns, Carol A.; Browning, Glenn F.; Benham, Michelle L.; Anderson, GA; Whithear, Kevin G.

doi:10.1080/03079459608419164

Cited by 11 publications

(8 citation statements)

References 8 publications

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“…High resistance rates were also noted with TMP + SMX and chloramphenicol in E. coli isolated from poultry despite the fact that the latter is not licensed for veterinary use in Saudi Arabia. This again could be associated with the misuse of spectinomycin as reported by Ginns et al . (1996) .…”

Section: Discussionmentioning

confidence: 59%

Antibiotic resistance of Escherichia coli isolated from poultry workers, patients and chicken in the eastern province of Saudi Arabia

Al-Ghamdi

El-Morsy

Al-Mustafa

et al. 1999

Tropical Med Int Health

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SummaryThe prevalence of antibiotic-resistant Escherichia coli isolates from faecal samples from 117 poultry industry workers, 100 patients and119 healthy chicken were compared. Resistance of E. coli chicken isolates to ampicillin, chloramphenicol, gentamicin, spectinomycin, tetracycline and trimethoprim ϩ sulphamethoxazole (TMP ϩ SMX) (range 57% -99.1%) were significantly higher than those isolated from patients (range 21.9% -71.4%) and workers (range 35% -71.8%). However, for drugs not used in poultry, such as amoxicillin ϩ cluvalanate (AMX ϩ CLV), ceftazidime and nitrofurantoin, resistance rates of chicken isolates (range 0% -2.6%) were significantly lower than those of patient isolates (range 8.7% -30%). Resistance to spectinomycin reached 96% in E. coli chicken isolates and 71% in organisms isolated from humans. Use of this drug in Saudi Arabia is mostly limited to veterinary purposes. Multidrug resistance is alarmingly high in all groups but was highest in chicken isolates (77.4%). Serotyping of E. coli isolates showed that 27% of the organisms isolated from patients were overlapping with 10.9% of the chicken isolates, indicating the possibility of chicken being a source of the resistance pool for humans. We therefore call for the banning of antibiotics in the poultry industry as growth promoters and recommend that their use be restricted to treating infections.

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Section: Discussionmentioning

confidence: 59%

Antibiotic resistance of Escherichia coli isolated from poultry workers, patients and chicken in the eastern province of Saudi Arabia

Al-Ghamdi

El-Morsy

Al-Mustafa

et al. 1999

Tropical Med Int Health

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“…E1043 was obtained 2 weeks later from a bird in the same flock and was resistant to most of the antimicrobial agents tested. The emergence in the flock of multiresistant E. coli strains, like E1043, was possibly due to the prophylactic administration of Linco-Spectin (lincomycin 222g/kg + spectinomycin 445g/kg; Ginns et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…The cloacal isolates were representative of the dominant E. coli population in the broiler breeder flock at the time of collection (Ginns et al, 1996). E956 was collected from a healthy 1-day-old bird and was sensitive to all the antimicrobial agents tested.…”

Section: Discussionmentioning

confidence: 99%

Development and application of an aerosol challenge method for reproduction of avian colibacillosis

et al. 1998

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We have developed a reliable aerosol challenge method for reproduction of avian colibacillosis. This method involves intranasal administration of infectious bronchitis virus (IBV) to 1-day-old birds followed by three aerosol administrations of E. coli at 3 to 4-day intervals. In four separate experiments there was no significant difference in virulence for a single isolate of E. coli (E3) whereas four other field isolates of E. coli ranged from highly virulent to avirulent. We also observed that the dominant E. coli population isolated from 1-day-old birds in a flock of broiler breeders was highly virulent but that the dominant E. coli population isolated from birds in the same flock 2 weeks later was avirulent. The dominant E. coli population isolated from 1-day-old birds in this flock was sensitive to all of the antimicrobial agents tested whereas the dominant E. coli population in the 2-week-old birds was multiresistant. A previous study has shown that it is likely that the changed resistance pattern of the dominant E. coli population in the flock was linked to the administration of antimicrobial agents.

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“…11 Although spectinomycin has limited applications in humans, veterinary use of the drug was found to be associated with crossresistance to other antimicrobial agents. 14 Lincomycin is a lincosamide antibiotic used in poultry for therapy of penicillin G-resistant organisms and anaerobic infections, or for growth promotion. 2 Although this drug is not commonly used in humans, its derivative, clindamycin, is widely employed in the treatment of Bacteroides fragilis infections.…”

Section: Discussionmentioning

confidence: 99%

Use of Antibiotics in the Poultry Industry in Saudi Arabia: Implications for Public Health

Al-Mustafa

Al-Ghamdi

2002

Ann Saudi Med

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Background:The use of antimicrobial agents in food-producing animals has become an important public health issue due to the spread of microbial resistance. This study was aimed at identifying the antimicrobial agents available for poultry use and highlighting their possible impact on public health. Materials and Methods: Twenty-three randomly selected poultry farms and all veterinary pharmacies in the Eastern Province of Saudi Arabia were surveyed for the antibiotics used or dispensed. Further, a comprehensive literature survey was performed. Results: Twenty-nine antimicrobial agents were identified as being available for poultry use, of which 22 (75.9%) were important for the treatment of human infections. Enrofloxacin, oxytetracycline, ampicillin, neomycin, sulphamethoxazole, colistin, doxycycline and erythromycin were the most frequently used drugs. Food-borne hypersensitivity reactions and the emergence of microbial resistance, as well as cross-resistance to the various groups of antibiotics in animals and its transfer to human pathogens, are well documented. Conclusion:The misuse of antibiotics in the local poultry industry poses a serious health risk to the public and may complicate the treatment of human infections. The veterinary use of antimicrobial agents, especially those with dual animal and human applications, should therefore be restricted. The establishment of a government department concerned with food and drug safety is also highly recommended.

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Antimicrobial resistance and epidemiology ofEscherichia coliin broiler breeder chickens

Cited by 11 publications

References 8 publications

Antibiotic resistance of Escherichia coli isolated from poultry workers, patients and chicken in the eastern province of Saudi Arabia

Antibiotic resistance of Escherichia coli isolated from poultry workers, patients and chicken in the eastern province of Saudi Arabia

Development and application of an aerosol challenge method for reproduction of avian colibacillosis

Use of Antibiotics in the Poultry Industry in Saudi Arabia: Implications for Public Health

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