Antimicrobial Resistance and Its Spread Is a Global Threat

Abstract

Antimicrobial resistance (AMR) is a challenge to human wellbeing the world over and is one of the more serious public health concerns. AMR has the potential to emerge as a serious healthcare threat if left unchecked, and could put into motion another pandemic. This establishes the need for the establishment of global health solutions around AMR, taking into account microdata from different parts of the world. The positive influences in this regard could be establishing conducive social norms, charting individual and group behavior practices that favor global human health, and lastly, increasing collective awareness around the need for such action. Apart from being an emerging threat in the clinical space, AMR also increases treatment complexity, posing a real challenge to the existing guidelines around the management of antibiotic resistance. The attribute of resistance development has been linked to many genetic elements, some of which have complex transmission pathways between microbes. Beyond this, new mechanisms underlying the development of AMR are being discovered, making this field an important aspect of medical microbiology. Apart from the genetic aspects of AMR, other practices, including misdiagnosis, exposure to broad-spectrum antibiotics, and lack of rapid diagnosis, add to the creation of resistance. However, upgrades and innovations in DNA sequencing technologies with bioinformatics have revolutionized the diagnostic industry, aiding the real-time detection of causes of AMR and its elements, which are important to delineating control and prevention approaches to fight the threat.

Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics

“…Antibiotics are valuable tools for fighting against bacterial infections. However, antibiotic resistance is a naturally occurring process. According to the CDC 2019 Antibiotic Resistance (AR) Threats Report, infections caused by antibiotic-resistant germs surpassed 2.8 million, with a mortality rate exceeding 35,000 in the U.S. each year .…”

“…Bacterial infections spread around us in the communities, food supplies, water, and soil. However, serious infections, especially with multidrug-resistant pathogens, are widely dispersed in healthcare facilities like hospitals, clinics, or nursing homes, called healthcare-associated infections (HAIs). , Unfortunately, antibiotics innovation and development entered a dark age after the 1960s because of the rapid emergence of resistance . Consequently, the generation of novel medications to control and treat infections caused by multidrug-resistant pathogens has become a pressing priority for the scientific community.…”

“…According to the CDC 2019 Antibiotic Resistance (AR) Threats Report, infections caused by antibiotic-resistant germs surpassed 2.8 million, with a mortality rate exceeding 35,000 in the U.S. each year. 1 Many of these infections have no treatment options. Bacterial infections spread around us in the communities, food supplies, water, and soil.…”

Antimicrobial Resistance Analysis of Escherichia coli Isolated from Pigeons in Qingdao, Shandong Province, China

“…Drug resistance increases the challenge around disease management, which has been documented to compromise the human immune system and increase complications and vulnerability after complicated surgeries involving cancer, knee replacement, dialysis, etc. [ 25 ]. Thus, monitoring drug-resistant E. coli from pigeons also takes great significance in maintaining public health safety in this region.…”

“…The development of AMR has been documented to be a natural process to enable survival of the bacteria, but has been fueled by human activities, including inappropriate prescription, excessive use of antibiotics as growth supplements in livestock, and the availability of few new antibiotics [ 26 ]. The mounting evidence around antibiotic usage practice being a crucial risk towards drug resistance necessitates the need for inculcating habitual and appropriately guided clinical management practices [ 25 ]. We should strengthen the feeding and management of pigeons, scientifically use veterinary antibiotics, reduce the emergence of numerous resistance mechanisms from overuse of antibiotics, and prevent its further spread to other host animals or humans.…”