Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence

Christaki, Eirini; Marcou, Markella; Tofarides, Andreas

doi:10.1007/s00239-019-09914-3

Cited by 482 publications

(372 citation statements)

References 119 publications

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“…The well-known antimicrobial resistance caused by the misuse of antibiotics drugs in animal production, and the EU ban on their in-feed use (Regulation EC/1831/2003) has led to an increase in the incidence of livestock disease and economic damage. For several years, research has dedicated great efforts to investigating alternatives able to sustain production without causing an increase of antimicrobial resistance and several natural products have been investigated [11,12].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Effects of Black Soldier Fly and Yellow Mealworm Fats and Their Impact on Gut Microbiota of Growing Rabbits

Dabbou

Ferrocino

Gasco

et al. 2020

Animals

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This study aimed to evaluate the in vitro antimicrobial activities of two types of insect fats extracted from black soldier fly larvae (HI, Hermetia illucens L.) and yellow mealworm larvae (TM, Tenebrio molitor L.) and their effects as dietary replacement of soybean oil (S) on cecal fermentation pattern, and fecal and cecal microbiota in rabbits. A total of 120 weaned rabbits were randomly allotted to three dietary treatments (40 rabbits/group) —a control diet (C diet) containing 1.5% of S and two experimental diets (HI diet (HID) and TM diet (TMD)), where S was totally substituted by HI or TM fats during the whole trial that lasted 41 days. Regarding the in vitro antimicrobial activities, HI and TM fats did not show any effects on Salmonella growth. Yersinia enterocolitica showed significantly lower growth when challenged with HI fats than the controls. The insect fat supplementation in rabbit diets increased the contents of the cecal volatile fatty acids when compared to the control group. A metataxonomic approach was adopted to investigate the shift in the microbial composition as a function of the dietary insect fat supplementation. The microbiota did not show a clear separation as a function of the inclusion, even if a specific microbial signature was observed. Indeed, HI and TM fat supplementation enriched the presence of Akkermansia that was found to be correlated with NH3-N concentration. An increase in Ruminococcus, which can improve the immune response of the host, was also observed. This study confirms the potential of HI and TM fats as antibacterial feed ingredients with a positive influence on the rabbit cecal microbiota, thus supporting the possibility of including HI and TM fats in rabbit diets.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Effects of Black Soldier Fly and Yellow Mealworm Fats and Their Impact on Gut Microbiota of Growing Rabbits

Dabbou

Ferrocino

Gasco

et al. 2020

Animals

View full text Add to dashboard Cite

show abstract

“…The well-known antimicrobial resistance caused by the misuse of antibiotics drugs in animal production, and the EU ban for their in-feed use [Regulation EC/1831/2003] has led to an increase of the incidence of livestock disease and economic damages. Since several years, research dedicated great efforts to investigate alternatives able to sustain production without causing an increase of antimicrobial resistance and several natural products have been investigated [9,10].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effects of Black Soldier Fly and Yellow Mealworm fats and their impact on gut microbiota of growing rabbits

Dabbou

Ferrocino

Gasco

et al. 2020

Preprint

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Background The study aimed to evaluate the in vitro antimicrobial activities of two types of insect fats extracted from black soldier fly larvae (HI, Hermetia illucens L.) and yellow mealworm larvae (TM, Tenebrio molitor L.) and their effects as dietary replacement of soybean oil (S) on caecal fermentation pattern, and faecal and caecal microbiota in rabbits. Results A total of 120 weaned rabbits were randomly allotted to 3 dietary treatments (40 rabbits/group): a control diet (C diet) containing 1.5% of S and two experimental diets (HID and TMD) where S was totally substituted by HI or TM fats. Regarding the in vitro antimicrobial activities, HI and TM fats did not show any effects on Salmonella growth. Yersinia enterocolitica showed lower growth when challenged with insect fats than the controls. The insect fat supplementation in rabbit diets increased the contents of the caecal volatile fatty acids when compared to the control group. A metataxonomic approach was adopted to investigate the shift in the microbial composition as a function of the dietary insect fat supplementation. The microbiota did not show a clear separation as a function of the inclusion, even if a specific microbial signature was observed. Indeed, HI and TM fat supplementation enriched the presence of Akkermansia that was found to be correlated with NH3-N concentration. An increase in Ruminococcus, which can improve the immune response of the host, was also observed. Conclusions This study confirms the potential of HI and TM fats as antibacterial feed ingredients with a positive influence on the rabbit caecal microbiota, thus supporting the possibility of including HI and TM fats in rabbit diets.

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“…The therapeutic use of antibiotics for the treatment of severe infections, as well as their prophylactic use in certain clinical situations, has proven to be powerful and crucial for the betterment of human health [13]. Nonetheless, a major consequence of the expanded use of antibacterial agents has been the heightened presence of resistant organisms as a result of the increase in evolutionary selective pressures [14].…”

Section: The Boom Of Antibacterial Agentsmentioning

confidence: 99%

The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?

et al. 2021

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Extended overuse and misuse of antibiotics and other antibacterial agents has resulted in an antimicrobial resistance crisis. Bacteriophages, viruses that infect bacteria, have emerged as a legitimate alternative antibacterial agent with a wide scope of applications which continue to be discovered and refined. However, the potential of some bacteriophages to aid in the acquisition, maintenance, and dissemination of negatively associated bacterial genes, including resistance and virulence genes, through transduction is of concern and requires deeper understanding in order to be properly addressed. In particular, their ability to interact with mobile genetic elements such as plasmids, genomic islands, and integrative conjugative elements (ICEs) enables bacteriophages to contribute greatly to bacterial evolution. Nonetheless, bacteriophages have the potential to be used as therapeutic and biocontrol agents within medical, agricultural, and food processing settings, against bacteria in both planktonic and biofilm environments. Additionally, bacteriophages have been deployed in developing rapid, sensitive, and specific biosensors for various bacterial targets. Intriguingly, their bioengineering capabilities show great promise in improving their adaptability and effectiveness as biocontrol and detection tools. This review aims to provide a balanced perspective on bacteriophages by outlining advantages, challenges, and future steps needed in order to boost their therapeutic and biocontrol potential, while also providing insight on their potential role in contributing to bacterial evolution and survival.

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Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence

Cited by 482 publications

References 119 publications

Antimicrobial Effects of Black Soldier Fly and Yellow Mealworm Fats and Their Impact on Gut Microbiota of Growing Rabbits

Antimicrobial Effects of Black Soldier Fly and Yellow Mealworm Fats and Their Impact on Gut Microbiota of Growing Rabbits

Antimicrobial effects of Black Soldier Fly and Yellow Mealworm fats and their impact on gut microbiota of growing rabbits

The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?

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