Antimicrobial resistant escherichia coli and sequence type 131 in urinary tract infections

Chu, Pui-Shan; 朱佩珊,

doi:10.5353/th_b5303900

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“…SNPs in mdh gene are C288T and C525T, whereas SNPs in gyrB gene are C621T, C729T, and T735C. The two genes have many alleles so that allele-specific for ST131 671 bp [11] were tried to be detected in that study. With the primers pairs constructed with these SNPs, both mdh and gyrB allelicspecific PCRs were consistently successful with 34 ST131 control strains.…”

Section: Discussionmentioning

confidence: 99%

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Wang

2016

AJP

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Background: Escherichia coli sequence type 131 (ST131) has emerged among bacteria causing urinary tract infection (UTI) in the previous decade. This ST contains multiple drug resistant (MDR) genes together with genes encoding many virulence factors. As a result, this strain of uropathogenic E. coli (UPEC) gives rise to treatment failure with consequent prolonged stay in a hospital. Therefore, earlier identification of this strain in the hospital has advantage in combating severe type of UTI. Objective: To detect ST 131 strains in MDR UPEC isolates from two hospitals of Sabah. Materials and Methods: Antibiotic susceptibility tests were performed to detect MDR isolates. Two polymerase chain reactions (PCRs) including mdh and gyrB allelic-specific PCR were performed on these MDR isolates to detect ST131 strains. Results: The results showed four isolates were resistant to TMP-SMX, gentamycin, ciprofloxacin, and cefotaxime, and three isolates of these were investigated to be ST131 strains by two PCR reactions. Conclusion: There is the presence of ST131 strains in hospitals of Sabah. This information will be a guideline for the clinician in the management of UTI in the clinical settings.

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Section: Discussionmentioning

confidence: 99%

Untitled

Wang

2016

AJP

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Antimicrobial resistant escherichia coli and sequence type 131 in urinary tract infections

Cited by 1 publication

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