Antimicrobial susceptibility of Propionibacterium acnes isolates from acne patients in Colombia

Abstract

Antimicrobial resistance in P. acnes in this Colombian population has a lower prevalence than those reported in Europe and follows a similar pattern to findings elsewhere in Latin America. Resistance is demonstrated even in isolates from patients with no previous history of antibiotic use. Resistance to erythromycin is most commonly observed. Minocycline emerges as the most effective antibiotic.

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine®

“…29 In a Colombian study in 100 patients with facial acne, C. acnes antimicrobial resistance was demonstrated even in isolates from patients with no previous history of antibiotic use. 30 To our knowledge, this is the first study to report the level of resistance to antibiotic of Cutibacterium spp. in healthy controls.…”

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AbstractObjective Our main objective was to compare Cutibacterium acnes (C. acnes) skin colonisation in patients with mild to moderate acne versus healthy controls and secondly, to evaluate a Myrtacine â -based cream on C. acnes total population and antibioresistant Cutibacteria in patients with acne.Methods In 60 acne patients (Global Acne Severity Scale, GEA grades 2-3), of mean age 20 [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Results We first showed (i) high and similar levels of C. acnes colonisation in superficial pilosebaceous follicles and detection of EryR and ClnR strains in both acne and control groups; (ii) different repartition of phylotypes in acne patients versus healthy control, with a predominance of phylotype IA in acne patients and a link between phylotype IA and erythromycin resistance. Besides, after treatment with the Myrtacine â -based cream in acne patients, there was no change in C. acnes total load, but a significant decrease of EryR Cutibacteria, reduced porphyrin production by C. acnes, a decrease in acne severity (GEA), associated with reduced retentional and inflammatory lesions.

Conclusion Cutibacterium acnes colonisation was not significantly different in acne versus control groups.

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In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

“…There is widespread resistance in P. acnes due to overuse of topical and systemic antibiotics for treatment of acne vulgaris [3,[8][9][10][11][12][13][14][15][16], as shown in Table 4. Various studies have used different interpretative criteria to estimate the resistance among P. acne strains to different anti-acne drugs.…”

Antibiotic resistance in acne: is it time to look beyond antibiotics and Propionobacterium acnes?

“…The majority of sampling techniques, such as swab and scrape, target the superficial epithelial bacterial populations . This is not representative of the true levels of P. acnes , which is what has been used in the recent published studies …”