Antimicrobial susceptibility of long term care facility and general practice urine samples in patients 65 years and older: an observational study

Fleming, Aoife; Barry, Louise; Byrne, Stephen; Prentice, Michael B.

doi:10.1093/eurpub/ckw138

Cited by 5 publications

(8 citation statements)

References 10 publications

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“…These beta-lactam antibiotics work by inhibiting cross-linkage of the peptidoglycan cell wall of bacteria. NICE Guidance advises that amoxicillin should only be prescribed after susceptibility testing has been performed, 9 and our data confirm that, with high resistance rates. Cephalosporins have a broader range of activity than amoxicillin, which is largely because of better beta-lactamase stability.…”

Section: Treatment Of Uncomplicated Uti’ssupporting

confidence: 77%

“…This guidance recommends the use of nitrofurantoin as the first-line treatment option in the management of uncomplicated UTI’s. 9 Nitrofurantoin is an antibiotic with bacteriostatic and bactericidal properties, which disrupts both cellular respiration and the synthesis of nucleic acids. This NICE recommendation is supported by evidence which shows that nitrofurantoin lacked a dose–response relationship with resistance, unlike other antibiotics.…”

Section: Treatment Of Uncomplicated Uti’smentioning

confidence: 99%

“…The second-choice antibiotics recommended by NICE are pivmecillinam (a penicillin) or fosfomycin, 8 the latter has the advantage of being a single 3-g oral dose. The use of these drugs in the UK has been constrained by the fact that many laboratories do not test or report susceptibilities to these agents.…”

Section: Treatment Of Uncomplicated Uti’smentioning

confidence: 99%

“…This is especially important given that NICE Guidance recommends that the majority of women with uncomplicated UTI are treated empirically without culture confirmation of their infection. 9…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic resistance in urinary tract infections: A re-visit after five years and experience over two sites

et al. 2020

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Objective The aim of this study was to repeat a previous audit, performed from 2009 to 2013, for the cohort of 2018 to determine how the resistance rates in urinary pathogens in women over 18 years of age have changed. A secondary aim of the study was to use resistance data from a different UK hospital in the same year to compare differences in resistance rates across different geographic locations Study design This was a retrospective study of all positive urine cultures grown from female patients attending two different hospitals in the year 2018. Resistance patterns were analysed. Results The resistance rate to co-amoxiclav continues to increase with amoxicillin retaining high resistance patterns. There are some significant differences in resistance patterns between the different locations. Conclusion Antimicrobial resistance is a significant problem in the UK particularly in antibiotics used to treat UTI. These patterns can vary across different geographical locations and over time; therefore, up-to-date knowledge of local anti-biotic resistance is essential when making an appropriate prescription choice.

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Section: Treatment Of Uncomplicated Uti’ssupporting

confidence: 77%

Section: Treatment Of Uncomplicated Uti’smentioning

confidence: 99%

Section: Treatment Of Uncomplicated Uti’smentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibiotic resistance in urinary tract infections: A re-visit after five years and experience over two sites

et al. 2020

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“…As maiores resistências nos mais idosos poderão estar relacionadas com o aumento das hospitalizações e com o domicílio em lares, ambientes onde as resistências parecem ser maiores do que na comunidade. 6,24 Linhares et al também detetou maiores resistências com o aumento da idade e no sexo masculino. 6 As ITU mais comuns são as cistites não complicadas, pelo que é de grande utilidade o conhecimento da epidemiologia e dos padrões de resistência aos antibióticos dos seus agentes etiológicos.…”

Section: Discussionunclassified

Perfil de Sensibilidade aos Antibióticos na Infeção Urinária em Ambulatório no Distrito de Coimbra: Um Estudo Transversal

C¹,

Rosendo²,

Santiago³

2019

Acta Med Port

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Introduction: Urinary tract infections in the community setting are quite common. It is necessary to be aware of antibiotic susceptibility patterns in order to provide rational empirical therapy. The aim of this study is to determine the frequency and antimicrobial susceptibility of the strains responsible for urinary tract infections in primary health care, in the district of Coimbra, Portugal.Material and Methods: In this observational and cross-sectional study, we analyzed 7134 positive urine cultures of outpatient laboratories in the district of Coimbra, over one year. In most cases, a positive culture was defined by a threshold of 105 colony-forming units per milliliter and was conducted by the automated system VITEK® 2, by bioMérieux. We used descriptive and inferential statistics to determine the prevalence and antimicrobial susceptibility of bacteria and to ascertain whether there were differences associated with sex and age.Results: From the total of positive cultures, 83.4% pertained to females and 41.0% to individuals over 75 years old. Escherichia coli was the most frequent strain (63.9%), although its prevalence was lower (p < 0.001) in males and individuals over 75 years old. Its susceptibility to fosfomycin and nitrofurantoin was higher than 95% and with ciprofloxacin and trimethoprim/sulfamethoxazole it was lower than 80%. Resistances were more frequent (p < 0.001) in males and in the elderly.Discussion: Escherichia coli was the most frequent strain, revealing less resistance to fosfomycin and nitrofurantoin. Antimicrobial susceptibility was lower in the elderly and in males, populations in whom empirical therapy may be less successful.Conclusion: In order to improve clinical results, we recommend periodic surveillance of antimicrobial susceptibility, which could enable the provision of efficient information to clinicians, namely those who prescribe empirically for such infections, as well as standardization of identification methods of bacterial strains diagnosis and of the antibiotic kits to be tested.

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Healthcare-associated infections and antimicrobial use in long-term care facilities (HALT3): an overview of the Italian situation

Furmenti

Rossello

Bianco

et al. 2019

Journal of Hospital Infection

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Antimicrobial susceptibility of long term care facility and general practice urine samples in patients 65 years and older: an observational study

Abstract: This study highlights the need for continuous surveillance of antimicrobial susceptibility trends in LTCFs. Antimicrobial stewardship strategies are urgently required to address antimicrobial resistance and appropriate antimicrobial prescribing in the LTCF setting.

Cited by 5 publications

References 10 publications

Antibiotic resistance in urinary tract infections: A re-visit after five years and experience over two sites

Antibiotic resistance in urinary tract infections: A re-visit after five years and experience over two sites

Perfil de Sensibilidade aos Antibióticos na Infeção Urinária em Ambulatório no Distrito de Coimbra: Um Estudo Transversal

Healthcare-associated infections and antimicrobial use in long-term care facilities (HALT3): an overview of the Italian situation

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