Antineoplastic drugs

Friedman, Jan M.; Weber-Schöndorfer, Corinna

doi:10.1016/b978-0-12-408078-2.00014-7

Cited by 3 publications

(2 citation statements)

References 162 publications

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“…İçlerinde ABD ve Türkiye'nin de bulunduğu, ilaca ruhsat vermemiş olan bazı ülkelerde bu tabloyla karşılaşılmamış olması büyük bir avantaj sayılmaktadır (10,22). İlaç halen lepra tedavisinde kullanılmakta, ayrıca immünmodülatör olarak sistemik lupus eritematozus, greft versus host hastalığı, multipl myeloma, myelodisplazi ve bazı neoplazmların tedavisinde de yer bulmaktadır [40]. Ancak gebeler için en yüksek oranda uyarılarda bulunulmakta ve ciddi kayıtlar tutulmaktadır.…”

Section: Klinik Değerlendirmelerunclassified

Türkiye’de ve Dünyada Teratojenite Bilgi Servislerinin Çalışma Koşulları ve Sağladıkları Hizmetler

Çeliker¹,

Göçer²

2021

Hacettepe University Journal of the Faculty of Pharmacy

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The frequency of drug use during pregnancy and increased drug diversity increased the risk of teratogenicity. Since ethical reasons complicates the process of obtaining and evaluating the correct information in pregnant women, the collection regularly and protection carefully of obtained data is of utmost importance. Studies on these data should be conducted, and pregnant women and physicians should be guided by this information. The anxiety that started in pregnant women and physicians after the thalidomide disaster experienced in the 1960s caused a need for counseling more detailed and this process resulted in the establishment of teratology information and/or counseling services. These services have increased considerably in terms of number and have improved in terms of functioning. The aim of this review is to submit a compilation related to the literature regarding the history, working conditions and services they provide of Turkish and the world teratogenicity consultancy services.

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Section: Klinik Değerlendirmelerunclassified

Türkiye’de ve Dünyada Teratojenite Bilgi Servislerinin Çalışma Koşulları ve Sağladıkları Hizmetler

Çeliker¹,

Göçer²

2021

Hacettepe University Journal of the Faculty of Pharmacy

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“…Methotrexate is known as amethopterin which suppresses the immune system and used as chemotherapeutic agents. It was synthesized in 1947 and in 1956 it proved to cure as for metastatic cancer [1].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review of synthesized derivatives of methotrexate in relation to their anticancer potential.

Nemat¹,

Iqbal²,

Mehmood³

2020

medical-oncology

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Methotrexate (MTX) is a chemotherapeutic agent with certain side effects. Efforts were made to synthesize analogues of MTX to enhance the activity and reduce side effects. Various derivatives were synthesized by structural modification of parent drug and mainly assayed for anticancer activity and binding affinity with dihydrofolatereductase (DHFR) and folylpolyglutamate synthetase (FPGS). In vitro study was carried out on cell lines CCRF. CEM, ATCC8, L. Casei, P388, L1210, L1210/R81, and H35. These synthesized derivatives have been assayed for human squamous cell carcinoma namely SSC25, SSC68, SSC78, SSC25/R1, SSC68/R1, and SSC78/R1. Some modification proved to enhance anticancer activity while others are detrimental. Some of derivatives were also tested for other biological activity like anti-malarial, anti-bacterial and anti-diabetic and show better activity. This article deals with a comprehensive overview of the synthesized derivatives by structural modifications and the impact of these modifications on its activity.

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