Antioedematogenic activity, acetylcholinesterase inhibition and antimicrobial properties of <i>Jacaranda oxyphylla</i>

Pereira, Vinícius Oliveira de Moura; Silva, R. R.; Santos, Marcelo H. dos; Dias, Danielle Ferreira; Moreira, Maria Eliza de Castro; Takahashi, Jacqueline A.

doi:10.1080/14786419.2015.1095744

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…The component presented potent AChE inhibition activity where the result was further confirmed by docking analysis. This is in agreement with a recent study (Pereira et al, 2016) describing AChE activity of β-sitosterol which was better than oleanolic acid, ursolic acid, and corosolic acid. On the other hand, ethanol extracts of S. multicaulis exhibited a high level of inhibitory activity against BChE in contrast to AChE.…”

Section: Neuroprotectivesupporting

confidence: 93%

“…Results showed that the fraction was effective against S. aureus , B. subtilis , P. aeruginosa , and Escherichia coli . β‐sitosterol extracted from Jacaranda oxyphylla exhibited strong antimicrobial effects against Bacillus cereus , S. aureus , E. coli , Salmonella typhimurium , and Candida albicans (Pereira et al, 2016). Some of these microbes have also been used by Hamed et al (2017) to evaluate the bioactivity of β‐sitosterol purified from methanol extract of Abutilon hirtum .…”

Section: Other Pharmacological Properties Of β‐Sitosterolmentioning

confidence: 99%

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Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Nandi,

Nag,

Khatua

et al. 2023

Phytotherapy Research

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Sterols, including β‐sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of β‐sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. β‐sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of β‐sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of β‐sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of β‐sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of β‐sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of β‐sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. β‐sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of β‐sitosterol have also shown anti‐cancer effects. However, research in the field of drug delivery and the detailed mode of action of β‐sitosterol‐mediated anticancer activities remains limited. β‐sitosterol, as a non‐toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, β‐sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of β‐sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on β‐sitosterol as a potent superfood in combating cancer.

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Section: Neuroprotectivesupporting

confidence: 93%

Section: Other Pharmacological Properties Of β‐Sitosterolmentioning

confidence: 99%

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Nandi,

Nag,

Khatua

et al. 2023

Phytotherapy Research

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“…Estado actual de las biotransformaciones con miras a la apertura de una línea de investigación en el laboratorio de fitoquímica de la Universidad Tecnológica de Pereira [Trabajo final de grado]. Universidad Tecnológica dePereira, 2016.…”

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Review on antioxidants and evaluation procedures

Kumar

Sharma

Vasudeva

2017

Chin. J. Integr. Med.

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Antioxidants are the substances that are capable of counteracting the damaging effects of the physiological process of oxidation occur in animal tissues. These may be nutrients (vitamins and minerals) as well as enzymes (proteins) in our body that assist in chemical reactions. They are believed to play a role in preventing the development of chronic diseases like cancer, diabetes, heart disease, stroke, Alzheimer's disease, rheumatoid arthritis, and cataracts etc. The present review article emphasizes on the various aspects of oxidants and antioxidants viz. definition, types, causes, mechanism, functions, adverse effects along with various in vivo and in vitro models of evaluation of antioxidant activity of new molecule, compounds or any plant or plant part. This review is one of its kinds which will be of great importance for researchers working in this area in search of antioxidant moieties and their biological evaluation.

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“…The flowers of this tree are used as medicinal treatments and have been attributed with anti-inflammatory, anti-parasitic, anti-fungal, and anti-cancer properties ( Hussain et al., 2007 ), while other species in this genus have been used to treat both viral and bacterial infections ( Gachet and Schühly, 2009 ). Pereira et al. (2015) reported an inhibition halo of 96.9% and 96.6% on Bacillus cereus and S. aureus, respectively, using an ethanol extract of leaves of J. oxyphylla .…”

Section: Resultsmentioning

confidence: 99%

Jacaranda flower (Jacaranda mimosifolia) as an alternative for antioxidant and antimicrobial use

Aguirre‐Becerra

Pineda-Nieto

García‐Trejo

et al. 2020

Heliyon

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Antimicrobial resistance to antibiotics is a serious health problem worldwide, for this reason, the search for natural agents with antimicrobial power against pathogenic microorganisms is of current importance. The objective of this work was to evaluate the antioxidant capacity (ABTS+ and DPPH), antimicrobial activity, and polyphenol compounds of methanolic and aqueous extracts of Jacaranda mimosifolia flowers. The antimicrobial activity against Bacillus cereus ATCC 10876 , Bacillus subtilis ATCC 6633 , Enterococcus faecalis ATCC 51299 , Escherichia coli ATCC 25922 , Listeria monocytogenes ATCC 19115 , Pseudomonas aeruginosa ATCC 27853 , Salmonella typhimurium ATCC 14028, Staphylococcus aureus ATCC 25923, and Streptococcus mutans ATCC 25175, was determined using the Kirby Bauer technique. The results of polyphenolic compounds showed a high amount of total flavonoids in the methanolic and aqueous extracts (503.3 ± 86.5 and 245. 7 ± 27.8 mg Rutin Equivalents/g DW, respectively). Quercetin, gallic acid, caffeic acid, and rutin were identified by the HPLC-DAD technique, while in the GC-MS analysis, esters, fatty acids, organic compounds, as well as monosaccharides were identified. Higher antioxidant capacity was detected by the ABTS technique (94.9% and 62.6%) compared to DPPH values (52.5% and 52.7 %) for methanolic and aqueous extracts, respectively. The methanolic extract showed a greater inhibitory effect on gram-positive bacteria, with a predominant higher inhibition percentage on Listeria monocytogenes and Streptococcus mutans (86% for both). In conclusion, Jacaranda flower extracts could be a natural antimicrobial and antioxidant alternative due to the considerable amount of polyphenolic compounds, and serve as a sustainable alternative for the isolation of active ingredients that could help in agriculture, aquaculture, livestock, pharmaceutics, and other industrial sectors, to remediate problems such as oxidative stress and antimicrobial abuse.

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Antioedematogenic activity, acetylcholinesterase inhibition and antimicrobial properties of Jacaranda oxyphylla

Cited by 7 publications

References 23 publications

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Review on antioxidants and evaluation procedures

Jacaranda flower (Jacaranda mimosifolia) as an alternative for antioxidant and antimicrobial use

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