Antioxidant activities and lipid lowering effects of isoflavone in male rabbits

Yousef, Mokhtar I.; Kamel, Kamel I.; Esmail, Alshaimaa M.; Baghdadi, Hoda H.

doi:10.1016/j.fct.2004.04.012

Cited by 99 publications

(71 citation statements)

References 33 publications

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“…Alternatively they may inhibit the activity of pro-oxidant enzymes, which are responsible for their production, with a protective effect of LDL from the attack of free radicals (Cos et al, 2002), or even saving α-tocopherol of LDL or the regeneration of the radical forms of α-tocopherol (Zhou et al, 2005). Corino et al (2007) also showed a significant reduction in TBARS in weaned piglets fed a supplemented concentrate with verbascoside, as did Yousef et al (2004) in rabbits fed with isoflavones supplement. This was most likely due to the ability of phenolic compounds to provide hydrogen atoms to free radicals, leading to a protective effect from oxidative damage at the cellular level of DNA, proteins, and membrane lipids.…”

Section: Blood Parametersmentioning

confidence: 89%

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Casamassima¹,

Palazzo²,

Vizzarri³

et al. 2013

Czech J. Anim. Sci.

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ABSTRACT:Two different doses of a dietary verbascoside-based supplement were evaluated on various blood parameters and on productive performance in young weaned hares reared intensively from 28 to 90 days of age. The study lasted for 62 days and it was conducted on 210 young hares divided into three homogeneous groups of 70 animals each, consisting of a control group and two experimental groups. Each group received the dietary supplement in the feed, titrated to 0.5% verbascoside, 1 kg/t of concentrate (LVB group) and 2 kg/t of concentrate (HVB group). The experimental reliefs included the measurement of blood parameters such as triglycerides, total cholesterol, high density lipoprotein cholesterol, and bilirubin, along with some markers of oxidative status in plasma such as reactive oxygen metabolites, thiobarbituric acid-reactive substances, and vitamins A and E. Various productive parameters were also measured such as body weight and growth rate, food consumption, and feed conversion. The experimental treatment resulted in a significant decrease in triglycerides (P < 0.01) and bilirubin (P < 0.05) and an increase in high density lipoprotein cholesterol (P < 0.01) both in the low verbascoside (LVB) and high verbascoside (HVB) experimental groups. In addition, the oxidative plasma stability in blood also improved, with a significant decrease in the concentration of reactive oxygen metabolites (P < 0.01) and thiobarbituric acid-reactive substances (P < 0.01), along with increased levels of vitamin E (P < 0.05). The productive performance was not statistically influenced by the experimental treatment, except for the growth rate which increased significantly (P < 0.05) in the experimental LVB and HVB groups: 6.9% and 8.7% respectively compared with the control group.

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Section: Blood Parametersmentioning

confidence: 89%

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Casamassima¹,

Palazzo²,

Vizzarri³

et al. 2013

Czech J. Anim. Sci.

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“…Flavonoids have antibacterial, astringent, detergent and abrasive properties (Almas and Stakiw, 2000;Almas, 2002). Besides flavonoids, both polyphenolic compounds and certain alkaloids seem to stimulate immune function, reduce cholesterol level and play a role in the prevention of a number of chronic diseases such as cancer and cardiovascular disease in rabbits (Chang and Gershwin, 2000;Jeon et al, 2001;Yousef et al, 2004). The purpose of the present study was to evaluate how various productive and reproductive traits and the pre and post sexual maturity of Black Baladi rabbit males are affected by including Arak (Salvadora persica) as a dietary supplement.…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary addition of arak (Salvadora persica) on growth and reproductive performance in Black Baladi rabbit males.

El-Kholy¹,

T.S.T.²,

El-Aasar³

et al. 2010

World rabbit sci.

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Abstract:The study aimed to evaluate the effect of Arak (Salvadora persica) as feed additive on performance of pre and post-sexual maturity of rabbit males. A control diet was formulated with an estimated proportion of 18% crude protein and 14% crude fi bre. Another three diets were formulated supplementing control diet with 0.1 0.2 or 0.3% Arak. The Arak used in this study contained (as % DM basis): 27.9 ash, 12.4 crude protein, 1.7 ether extract and 8.0 crude fi bre. Ninety-six weaned Black Baladi (BB) male rabbits aged 30 d weighing 570±8.30 g (mean±standard error) were used (24 per diet). Daily weight gain and daily feed intake were recorded from weaning up to 70 d of age (slaughtering commercial age). At this time four rabbits from each group were slaughtered and genitalia were immediately taken and dissected. Blood samples were collected at 120 and 150 d of age from fi ve bucks from each group. At the age of maturity several reproductive traits were also recorded. Final body weight at 70 d of growing BB rabbit males increased linearly and quadratically (P<0.001) with maximum Arak inclusion (0.23%), whereas feed effi ciency improved linearly by 0.16±0.061 g/g (P=0.011) per increment of 1 unit of Arak inclusion. Weight of sexual-accessory glands at 70 d of age increased linearly and quadratically (P<0.01) as dietary concentrations of Arak increased, the highest values for genital organs weight being obtained by using 0.2% Arak. Plasma testosterone concentration, from 120 d to age of puberty, increased linearly by 5.87±1.69 ng/mL (P<0.001) with Arak inclusion. The minimum puberty age was obtained by 0.2% Arak inclusion (P=0.024). Sexual desire, mating activity, semen-ejaculate volume, advanced-sperm motility, sperm-cell concentration and total-sperm output were linearly and quadratically affected by Arak inclusion (P<0.05), being optimized for 0.2% Arak inclusion. In conclusion, the addition of 0.2% Arak (Salvadora persica) to the growing and mature BB male rabbit diets improved growth and reproductive capabilities.

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“…Accumulating evidence suggests that supplementation of additives with antioxidant function (such as vitamin E, selenium, glutamine, and arginine) to the feed of piglets (Ban et al, 2004;Huang et al, 2011;Xi et al, 2011;Zhan et al, 2011) can reduce the oxidative stress and protect the intestinal function. Soybean isoflavones (ISFs) are stronger antioxidants, and have been studied extensively (Yousef et al, 2004;Foti et al, 2005;Lee et al, 2005;Jiang et al, 2007;Dixit et al, 2012). ISFs may inhibit the production and enhance the clearance of free radicals by inducing endogenous antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), etc.…”

Section: Introductionmentioning

confidence: 99%

Effects of soybean isoflavone on intestinal antioxidant capacity and cytokines in young piglets fed oxidized fish oil

Huang

Jiang

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:To investigate the effect of glycitein, a synthetic soybean isoflavone (ISF), on the intestinal antioxidant capacity, morphology, and cytokine content in young piglets fed oxidized fish oil, 72 4-d-old male piglets were assigned to three treatments. The control group was fed a basal diet containing fresh fish oil, and the other two groups received the same diet except for the substitution with the same dosage of oxidized fish oil alone or with ISF (oxidized fish oil plus ISF). After 21 d of feeding, supplementation of oxidized fish oil increased the levels of malondialdehyde (MDA), oxidized glutathione (GSSG), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), nuclear factor κ B (NF-κB), inducible nitric oxide synthase (iNOS), NO, and Caspase-3 in jejunal mucosa, and decreased the villous height in duodenum and the levels of secretory immunoglobulin A (sIgA) and IL-4 in the jejunal mucosa compared with supplementation with fresh oil. The addition of oxidized fish oil plus ISF partially alleviated this negative effect. The addition of oxidized fish oil plus ISF increased the villous height and levels of sIgA and IL-4 in jejunal mucosa, but decreased the levels of IL-1β and IL-2 in jejunal mucosa (P<0.05) compared with oxidized fish oil. Collectively, these results show that dietary supplementation of ISF could partly alleviate the negative effect of oxidized fish oil by improving the intestinal morphology as well as the antioxidant capacity and immune function in young piglets.

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Antioxidant activities and lipid lowering effects of isoflavone in male rabbits

Cited by 99 publications

References 33 publications

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Effect of dietary addition of arak (Salvadora persica) on growth and reproductive performance in Black Baladi rabbit males.

Effects of soybean isoflavone on intestinal antioxidant capacity and cytokines in young piglets fed oxidized fish oil

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