Antioxidant activity and genotoxic effect on HeLa cells of phenolic compounds from infusions of Quercus resinosa leaves

Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth.

“…NCI-H23 cells were more susceptible to this compound than that of other cell lines with the lowest EC 50 at 3.26 ± 0.35 g/ml. Several of potent antioxidative compounds such as curcumin, resveratrol and catechin are reported as tumor-suppressing and cytotoxic-enhancing agents (Rao et al, 2007;Lantto et al, 2009;Rocha-Guzmán et al, 2009). Therefore, the remarkable cytotoxic effect of the compound might partially be ascribable to its antioxidant properties by perturbing the favorable redox condition in cancer cells and inducing cytotoxicity.…”

Antioxidant Activities of Chokeberry Extracts and the Cytotoxic Action of Their Anthocyanin Fraction on HeLa Human Cervical Tumor Cells

“…The FRAP assay was performed according to the method of Benzie and Strain. 20 The CUPRAC of chokeberries was determined according to a method reported before by Apak et al 21 The antioxidant capacity was measured by the ORAC assay, 22 performed as described previously. 23 The HPS assay was carried out following the procedure of Ruch et al 24 The results of antioxidant assays were expressed as micromoles of Trolox per gram fresh weight (FW).…”

“…The Pearson's correlation coefficient (r) between chokeberry polyphenolic content and antioxidant activity showed The antioxidant capacity evaluated with the SET methods ABTS, FRAP, and CUPRAC showed elevated values for correlation coefficient, whereas for the HAT assay 22 lower values were obtained, so it is possible that the antioxidant mechanism of the chokeberry extracts could be based on SET, a property due to the ability of the aromatic ring of anthocyanins to support an unpaired electron. 41 To the total antiradical activity of chokeberries anthocyanins have the highest contribution (53-56%), but proanthocyanidins and insoluble phenols contribute 35%, followed by phenolic acids and flavonols (9%).…”

Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine

“…studies have demonstrated that green tea and tea polyphenols have significant inhibitory effects on rodent colorectal carcinogenesis (Sadik, 2013;Yamane et al, 1991;Yang and Wang, 2010). In vitro data provided evidence that leaf infusions or extracts of Quercus are an important and feasible source of polyphenols with high antioxidant capacity, as well as anticarcinogenic activity in transformed human cells (Gamboa-Gómez et al, 2013;Rivas-Arreola et al, 2010;Rocha-Guzmán et al, 2009, 2012. Therefore, the present study explored the anticarcinogenic effect of leaf infusions of edible red Quercus species in rat colon carcinogenesis induced by DMH.…”

“…In this regard, Quercus resinosa leaves are used in the north of Mexico as a refreshing beverage (Luna-José et al, 2003). In previous in vitro studies, it was observed that extracts from Q. resinosa leaves presented high phenolic content, antioxidant capacity and cardioprotective effect (Rivas-Arreola et al, 2010;Rocha-Guzmán et al, 2009, 2012, and anticarcinogenic potential through amelioration of oxidative stress mechanisms (Rocha-Guzmán et al, 2009). …”