Antioxidant activity and hypoglycemic effect of ferulic acid in STZ‐induced diabetic mice and KK‐A^y mice

Abstract

Antioxidant activity and biological properties of ferulic acid (FA) are well recognized. This study was designed to estimate the potential utility of FA administered orally at low dosage for improvement of hyperglycemia in diabetes. With this aim we have evaluated the hypoglycemic effect of FA in two type diabetic animal models: (1) streptozotocin (STZ)-induced diabetic mice, a model of insulin-dependent diabetes mellitus (IDDM); (2) KK-Ay mice, a model of non-insulin dependent diabetes mellitus (NIDDM). In addition, we measured the production of thiobarbituric acid-reactive substances (TBARS) in brown adipose tissues of diabetic mice at the end of FA feeding experiment. FA at 0.01% and 0.1% of basal diet showed to suppress significantly blood glucose levels in STZ-induced diabetic mice. In KK-Ay mice 0.05% FA suppressed effectively blood glucose levels. In addition, FA inhibited the lipid peroxidation in brown adipose tissue of diabetic mice. Taken together, these findings suggest that dietary FA may be useful in alleviating oxidative stress and attenuating the hyperglycemic response associated with diabetes.

Ferulic acid prevents liver injury induced by Diosbulbin B and its mechanism

“…(Ligusticum) (8). FA exerts multiple biological activities such as antioxidant, and anti-inflammation (9,10) and it is known for treatment of Alzheimer's disease (11), cardiovascular disease (12), and cancer (13). In addition, FA is reported to have hepato-protective activity (14,15).…”

Biological activities of lignin hydrolysate-related compounds

“…As a result, the activity of these compounds helps increase the insulin level in the blood. Several studies have reported that treatment with ferulic acid or p-coumaric acid showed effective hypoglycemic activity in diabetic mice and that derivative compounds stimulated insulin secretion (33)(34)(35). Furthermore, the hydroxycinnamic acids have been utilized as potent UV-radiation absorbent compounds.…”

Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

“…Previous studies reported that FA is an antioxidant that neutralizes free radicals such as superoxide, nitric oxide and hydroxyl radicals that may cause oxidative damage to cell membranes and DNA (Kanski et al, 2002;Ha et al, 2008). FA provides meaningful synergistic protection against oxidative stress in the skin and should protect against photoaging and skin cancer (Lin et al, 2005), hypoglycemic and hypolipidemic effects (Sri Balasubashini et al, 2003;Ohnishi et al, 2004;Jung et al, 2007), hypotensive effects (Suzuki et al, 2002), and anti-inflammatory effects (Yagi and Ohishi, 1979).…”