Antioxidant activity and kinetics studies of eugenol and 6-bromoeugenol

Mahboub, Radia; Memmou, Faiza

doi:10.1080/14786419.2014.958738

Cited by 31 publications

(19 citation statements)

References 36 publications

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“…The results of the present study showed ameliorative effects of eugenol in a dose dependent manner against arsenic mediated genotoxicity and oxidative stress. Our results agree with the results of a recent study by Mahboub and Memmou () where eugenol and 6 bromoeugenol has shown antioxidant activity. The antioxidant activity of eugenol was analyzed using 2, 2‐diphenyl‐1 picrylhydrazyl (DPPH) radical scavenging method.…”

Section: Resultssupporting

confidence: 93%

Protective role of eugenol on arsenic induced oxidative DNA damage and modulatory effect of GSTO2 polymorphism

et al. 2018

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Arsenic exposure is one of the major health problem worldwide. It is related with various cancers and numerous other pathological effects. The present work was aimed to study the ameliorative effects of eugenol against arsenic mediated oxidative DNA damage using Sister chromatid exchanges (SCE), comet, and lipid peroxidation assays as biomarkers. For the genotyping of GSTO2, PCR RFLP method was used. The treatment with sodium arsenite showed dose dependent increase in frequency of SCE, comet tail moment (Tm), and lipid peroxidation (TBARS levels). On administration of eugenol (10 and 20 µM) significant dose dependent decrease in the number of SCE, Tm value, and TBARS levels observed in arsenic treated cultured peripheral blood lymphocytes. Nonsignificant effects of GSTO2 polymorphism perceived on arsenic genotoxicity and eugenol antigenotoxicity. The results of the present work suggest a protective role of eugenol against arsenic induced genotoxic and oxidative damage in cultured human peripheral blood lymphocytes. Practical application Arsenic contamination of groundwater is one of the leading environmental issues worldwide. Chronic exposure of arsenic cause several health problems including tumor manifestation. The results of the present study suggest the use of indigenous dietary elements, herbs, shrubs as a safer and effective preventative medicine against heavy metal induced genotoxicity and oxidative stress.

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Section: Resultssupporting

confidence: 93%

Protective role of eugenol on arsenic induced oxidative DNA damage and modulatory effect of GSTO2 polymorphism

et al. 2018

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“…Eugenol and Clove oil have the ability to scavenge the free radicals [6,[12][13][14]. Eugenol showed inhibition of DPPH radical and hydroxyl radical at concentrations dependent manner.…”

Section: Antioxidant Activity Of Eugenolmentioning

confidence: 99%

Versatile and Synergistic Potential of Eugenol: A Review

Raja¹

2015

Pharm Anal Acta

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Eugenol (1-allyl-4-hydroxy-3-methoxybenzene) is the phenolic component of essential oil and the main constituent of Eugenia caryophyllata, Ocimmum gratissimum and several others medicinal plant. In view of its nonmutagenic and non-carcinogenic properties, eugenol is generally regarded as safe by the Food and Agricultural Organization of the United Nations. Eugenol has been recently shown to be effective for antimicrobials and treatment of different life threatening diseases including sepsis, leishmaniasis, and cancer. However overall, activity of eugenol is not discussed elsewhere. In this review, we discuss the current understanding of the mechanisms involved the antioxidant, antimicrobial, anticancer and anti-inflammatory potential of eugenol.

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“…In another study eugenol and 6 bromoeugenol has shown antioxidant activity. [21] The antioxidant activity was analysed using 2, 2-diphenyl-1 picrylhydrazyl (DPPH) radical scavenging method. Anethole has not explored much as eugenol for antigenotoxic and antioxidant potential although in one study Shahat et al [22] have found antioxidant potential of fennel against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Eugenol and Anethole on Arsenic Induced Oxidative Dna Damage in Cultured Human Peripheral Blood Lymphocytes

Bal

Yadav

Verma

et al. 2017

Int. J. Pharm. Sci. Drug Res.

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Arsenic contamination is one of the major health concerns all over the world and associated with various types of cancer and pathological effects. The production of reactive oxygen species (ROS) plays a crucial role in arsenic mediated toxicity. Several studies have shown that population constantly exposed to arsenic have substantial oxidative stress that, in turn, induces DNA damage. In the present work eugenol and anethole were investigated for their protective effect against arsenic mediated oxidative DNA damage in peripheral blood lymphocytes. Comet assay and lipid peroxidation was used as biomarker of genotoxicity and oxidative stress respectively. A dose dependent increase in tail moment and lipid peroxidation was observed when lymphocytes were treated with sodium arsenite. Treatment of arsenic (50µM) along with eugenol (20µM) and anethole (50µM) showed a significant decrease in the tail moment and lipid peroxidation in cultured peripheral blood lymphocytes. The decrease in the tail moment and lipid peroxidation was significantly higher in combined supplementation of eugenol and anethole as compared to individual administration. The results of the present study suggests ameliorative role of eugenol and anethole against arsenic induced genotoxic and oxidative damage in cultured human peripheral blood lymphocytes.

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Antioxidant activity and kinetics studies of eugenol and 6-bromoeugenol

Cited by 31 publications

References 36 publications

Protective role of eugenol on arsenic induced oxidative DNA damage and modulatory effect of GSTO2 polymorphism

Protective role of eugenol on arsenic induced oxidative DNA damage and modulatory effect of GSTO2 polymorphism

Versatile and Synergistic Potential of Eugenol: A Review

Ameliorative Effect of Eugenol and Anethole on Arsenic Induced Oxidative Dna Damage in Cultured Human Peripheral Blood Lymphocytes

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