Antioxidant activity and nano delivery of the most frequently applied stilbene derivatives: A brief and recent review

Abstract

As of recent, the appearance rate of several degenerative diseases and cancer influenced by oxidative stress continues to increase dramatically. Many compounds with high potential antioxidant activity have been explored and used extensively, i.e., as preventive or curative treatments. Stilbene and its derivates have high potential antioxidant activity contained in several botanical sources. To date, source exploration and antioxidant activity study of stilbene derivate has been reported. However, the nano-delivery of stilbene derivate meant to increase the antioxidant activity and stability is still a limited process. This review is devoted to brief and recent outlooks regarding the antioxidant activity and delivery system of the most frequently applied stilbene and its derivates, namely resveratrol and pterostilbene.

Medicinal chemistry perspective on the structure–activity relationship of stilbene derivatives

“…96 The hydroxy group is important for antioxidant activity, which can be due to the stabilization via resonance in the double-bond linker. 98 Resveratrol exhibited antioxidant activity in tumor initiation, promotion and progression, disturbing its progression by blocking the S and G2 phases of the cell cycle. 99 Jung et al 15 synthesized E-stilbene derivatives and evaluated their antioxidant activity.…”

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

“…The most frequently used stilbene derivate compounds are pterostilbene (PTS) and resveratrol (RSV). Exploited now in medicine, stilbenes possess a variety of biological activities, including antitumoral, anti-inflammatory, antioxidant, antibacterial, and antiviral activities [ 11 , 165 , 173 , 174 , 175 , 176 ]. Several systems have been studied for the TD of stilbenes, such as polyvinyl pyrrolidone-based dissolving microneedle patches, or different types of nanocarriers: anionic phospholipids, polymeric nanoparticles, lipid base nanoparticles, cyclodextrin complexation, electrospun nanofibers, nanocrystals, liposomes, dendrimers, and niosomes [ 11 , 174 , 177 , 178 , 179 , 180 ].…”