Antioxidant activity and phytochemical screening of Prosopis juliflora leaves extract

Badri, Ali M; Garbi, Mohamed I.; Gmaraldeen, Sara M; Magzoub, Amira A.; Ibrahim, Ibrahim T; Saleh, Mahmmoud S.; Kabbashi, Ahmed S.; Mohamed, Sameer G.

doi:10.30918/ampr.53.17.020

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…In this regard, Arya et al [36] used a leaf extract obtained from P. juliflora to provide anti-biofilm activity. Other authors revealed promising antimicrobial effects in several Prosopis species [37][38][39].…”

Section: Bioactivity Profile Of Prosopis Pallida Pod Flourmentioning

confidence: 97%

Nutritive and Bioactive Properties of Mesquite (Prosopis pallida) Flour and Its Technological Performance in Breadmaking

Gonzales-Barrón

Dijkshoorn

Maloncy

et al. 2020

Foods

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Although the nutritional profile, bioactivities, and uses of mesquite pod flour from various Prosopis species have been studied, limited research has been conducted on Prosopis pallida (Humb, & Bonpl. Ex Willd.) Kunth mesquite flour. This study aimed to characterize the nutritional quality and bioactive properties of P. pallida pod flour and to assess its technological performance in breadmaking as a partial replacer of white wheat flour. Peruvian P. pallida mesquite flour was found to have an appealing nutritional profile, with high contents of dietary fiber (29.6% dw) and protein (9.5% dw), and low contents of fat (1.0% dw) and carbohydrates (57.6% dw). It is a source of palmitic (12.6%), oleic (35.5%), and linoleic acids (45.8%), α-, β-, and γ- tocopherols, and contains phenolic compounds such as apigenin glycoside derivatives with proven antioxidant capacities. Extracts of P. pallida flour were also found to have antimicrobial and antifungal effects and did not show hepatoxicity. When formulated as a wheat flour replacer, increasing mesquite flour levels yield composite doughs of lower stickiness and extensibility, and composite breads of lower elasticity (p < 0.01). However, up to a level of 10%, mesquite flour significantly increases loaf volume, reduces crumb hardness, and produces a more uniform crumb of small size alveoli (p < 0.01). Considering the purpose of improving the nutritional and technological quality of wheat flour bread, the addition of P. pallida pod flour can be highly recommended.

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Section: Bioactivity Profile Of Prosopis Pallida Pod Flourmentioning

confidence: 97%

Nutritive and Bioactive Properties of Mesquite (Prosopis pallida) Flour and Its Technological Performance in Breadmaking

Gonzales-Barrón

Dijkshoorn

Maloncy

et al. 2020

Foods

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“…These studies examined the extracts of different parts of the plant while others analyzed purified phytochemicals, yet the studies are not interconnected. Chemical analysis of P. juliflora leaves ethanolic extract have shown antioxidant activity with the presence of alkaloids, tannins, flavonoids, coumarins and anthraquinone glycoside 14 . Aqueous extracts of the same leaves have also been evaluated to show similar composition with higher antioxidant activity in some studies 15 .…”

Section: Introductionmentioning

confidence: 99%

Novel Prosopis juliflora leaf ethanolic extract as natural antimicrobial agent against food spoiling microorganisms

Saleh

Abu-Dieyeh

2021

Sci Rep

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Fresh produces spoilage is a worldwide concern that accompany the global increase in food demand. Adverse human health and environmental effects of commercial spoilage control agents are major public concern. In this study, Prosopis juliflora leaves and fruit extracts had their antimicrobial activities evaluated against the growth of selected bacteria and yeast, and against mycelial growth and conidial germination of selected mycotoxins-producing fungi. P. juliflora water-soluble leaf ethanolic (PJ-WS-LE) extract with its novel extraction method showed the strongest antibacterial activity. Antimicrobial tests showed total inhibition of Botrytis cinerea, Alternaria alternata, Bacillus subtilis, Staphylococcus aureus and Candida albicans with MICs ranging between 0.125 and 1 mg/ml. Percent inhibition of mycelial growth (PIMG) of the extract was also determined against seven other fungal strains with highest value against Geotrichum candidum (66.2%). Even the least affected fungal strain showed alterations in their hyphae and spores exposed to PJ-WS-LE extract when observed using scanning electron microscope (SEM), alterations include exfoliated flakes, pores, vacuolation and applanation. Small-scale fruit bioassays controlled experiment showed high efficacy of the extract in protecting inoculated cherry tomato samples from B. cinerea and A. alternata infections. In conclusion, PJ-WS-LE extract is a feasible, natural antifungal agent that can replace common anti-spoiling chemicals.

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“…Also, this study on phytochemical screening revealed the absence of alkaloids and anthraquinones suggesting that these medicinal properties of Tephrosia vogelii found particularly in Tanzania may be branded mainly by tannins, steroids, terpenes, flavonoids and glycosides. On the other hand, the chemical nature of the phytochemicals analysed from this medicinal plant clearly coincides with the antimicrobial activities and ectoparasitic activities reported in the previous studies (Alamgir, 2017;Arif et al, 2011;Badri et al, 2017;Kenechukwu et al, 2012;Irawan et al, 2018;Makoshi & Arowolo, 2011;Mbunde et al, 2016;Mlozi et al, 2020;Murtaza et al, 2015;Nneka & Jude, 2012;Okpogba et al, 2019;Omodamiro & Amechi, 2013;Pietta, 2000;Priya et al, 2014;Ramawat & Mérillon, 2013;Sahu et al, 2014;Samuel et al, 2019;Sasidharan et al, 2011;Singh et al, 2017;Swamy et al, 2015;Trakranrungsie, 2011).…”

Section: Phytochemical Investigationsupporting

confidence: 86%

Antimicrobial investigation of Tephrosia Vogelii hook.f from Hai District in Tanzania towards development of antifungal agents for topical application

Hanolo

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Infectious diseases such as fungal diseases are the global health problem. Moreover, antimicrobial resistance to modern fungicides and antibiotics is even perplexing in the health settings. Such situation needs serious attention to search for alternative antimicrobial agents. Thus, this study aimed to investigate antimicrobial activity of Tephrosia vogelii Hook.f found in Tanzania and develop antifungal agents therefrom. The n-hexane, dichloromethane and methanolic extracts from leaves and roots of Tephrosia vogelii were evaluated for antimicrobial activity against Candida albicans (ATCC 90028), Cryptococcus neoformans (clinical isolate), Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC29953), Klebsiella pneumoniae (ATCC 700603) and Salmonella typhi (NCTC 8385). A serial dilution method using the sterilized 96 wells of polystyrene microliter plates were used to determine the minimum inhibitory concentrations (MIC) of extracts. The in vivo toxicity of methanolic leaf and root extracts was evaluated using albino rats. Extracts doses of 600, 1200, 2000 and 5000 mg/kg body weight were evaluated for lethality test while doses of 600, 1200 and 2000 mg/kg body weight subjected for sub-acute toxicity test. Gas Chromatography-Mass Spectrometry (GC-MS) technique was employed to appraise phytochemical compounds present. Antifungal agent for topical application was formulated and evaluated through in vitro and in vivo test to establish its effectiveness. The study results revealed that n-hexane and dichloromethane extracts exhibited the lowest activity. Equally, methanolic root and leaf extracts exhibited high activity at MICs ranging from 0.625 - 5.0 mg/mL against assayed pathogens. Phytochemical screening of both methanolic leaf and root extracts revealed the presence of tannins, flavonoids, terpenes, fatty acids and saponins. The GC-MS analysis unveiled the presence of ten phytocompounds. Five compounds; demethylmunduserone sumatrol, munduserone, hexadecanoic acid and hexadecanoic acid, methyl ester are new and this is the first time to be reported from Tephrosia vogelii. Furthermore, toxicity evaluation revealed that methanolic leaf and root extracts of Tephrosia vogelii were not deleterious at highest dose of 5000 mg/kg body weight. Though there was no mortality recorded, histopathological examination revealed toxicity indices due to vacuolation and necrosis in hepatocytes under treatment of methanolic root extracts of dose 2000 mg/kg body weight. The herbal cream prototype (CBTV3) was formulated, and it exhibited antimicrobial activity through in vitro and in vivo tests. The development of herbal cream prototype from Tephrosia vogelii Hook.f is hereby reported for the first time.

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Antioxidant activity and phytochemical screening of Prosopis juliflora leaves extract

Cited by 8 publications

References 7 publications

Nutritive and Bioactive Properties of Mesquite (Prosopis pallida) Flour and Its Technological Performance in Breadmaking

Nutritive and Bioactive Properties of Mesquite (Prosopis pallida) Flour and Its Technological Performance in Breadmaking

Novel Prosopis juliflora leaf ethanolic extract as natural antimicrobial agent against food spoiling microorganisms

Antimicrobial investigation of Tephrosia Vogelii hook.f from Hai District in Tanzania towards development of antifungal agents for topical application

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