Antioxidant Activity and Polyphenols Characterization of Four Monovarietal Grape Pomaces from Salento (Apulia, Italy)

Negro, Carmine; Aprile, Alessio; Luvisi, Andrea; Bellis, Luigi De; Miceli, Antonio

doi:10.3390/antiox10091406

Cited by 35 publications

(33 citation statements)

References 56 publications

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“…Fourteen flavan-3-ols, monomers, and trimers of (-)-epicatechin and (+)-catechin; 10 flavonols, derivatives of quercetin and kaempferol; 1 hydroxycinnamic acid, a derivative of p -coumaric acid; and 13 anthocyanins, 3- O -glycosides of malvidin, petunidin, cyanidin, peonidin, and delphinidin being the major components, were identified in the extract. These findings were in accordance with previously reported work, where anthocyanins were also the main compounds found in red grape skin extracts, and among them, Mv-3- O -glc was the most important [ 29 , 30 ]. As for the other compounds, the most abundant were reported to be phenolic acids, flavan-3-ols, and flavonols [ 31 ].…”

Section: Resultssupporting

confidence: 93%

Tempranillo Grape Extract in Transfersomes: A Nanoproduct with Antioxidant Activity

et al. 2022

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Polyphenols are gaining increasing interest due to their beneficial properties to human health. Grape pomace, the by-product of wine production, is a source of these bioactive compounds. An extract from Tempranillo grape pomace was obtained and characterized qualitatively and quantitatively. The major components found were anthocyanins, flavan-3-ols, and flavonols. To improve the bioavailability of these compounds, the extract was formulated in phospholipid vesicles, namely transfersomes. Spherical unilamellar vesicles around 100 nm each were obtained. The antioxidant activity of both the extract and the transfersomes was evaluated by using colorimetric assays (i.e., DPPH, FRAP, and Folin–Ciocalteu). The cells’ viability and the antioxidant activity were assessed in keratinocytes. The results showed that the extract and the transfersomes had no cytotoxic effects and exerted remarkable antioxidant activity, which was more evident in a vesicle formulation. These findings highlighted the potential of the Tempranillo grape pomace extract and the efficacy of the incorporation into phospholipid vesicles.

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Section: Resultssupporting

confidence: 93%

Tempranillo Grape Extract in Transfersomes: A Nanoproduct with Antioxidant Activity

et al. 2022

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“…Ten flavan-3-ols ((−)-epicatechin and (+)-catechin monomers and trimers); 11 flavanols (derivatives of quercetin, kaempferol and isorhamnetin); 1 dihydroflavanol; 1 hydroxycinnamic acid derivative of p -coumaric acid; 1 hydroxybenzoic acid; and 13 anthocyanins (3- O -glucosides of delphinidin, cyanidin, petunidin, peonidin, and malvidin) were identified in GE. These findings are in line with previous data reporting anthocyanins as the main components of extracts from red grape skin, with Mv-3- O -glc being the most abundant [ 20 , 21 ]. Among the other components, phenolic acids, flavan-3-ols and flavanols have been reported as the most representative classes [ 22 ].…”

Section: Resultssupporting

confidence: 93%

A Liposomal Formulation to Exploit the Bioactive Potential of an Extract from Graciano Grape Pomace

et al. 2022

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Antioxidant compounds with health benefits can be found in food processing residues, such as grape pomace. In this study, antioxidants were identified and quantified in an extract obtained from Graciano red grape pomace via a green process. The antioxidant activity of the extract was assessed by the DPPH and FRAP tests, and the phenolic content by the Folin–Ciocalteu test. Furthermore, nanotechnologies were employed to produce a safe and effective formulation that would exploit the antioxidant potential of the extract for skin applications. Anthocyanins, flavan-3-ols and flavanols were the main constituents of the grape pomace extract. Phospholipid vesicles, namely liposomes, were prepared and characterized. Cryo-TEM images showed that the extract-loaded liposomes were predominantly spherical/elongated, small, unilamellar vesicles. Light scattering results revealed that the liposomes were small (~100 nm), homogeneously dispersed, and stable during storage. The non-toxicity of the liposomal formulation was demonstrated in vitro in skin cells, suggesting its possible safe use. These findings indicate that an extract with antioxidant properties can be obtained from food processing residues, and a liposomal formulation can be developed to exploit its bioactive value, resulting in a promising healthy product.

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“…The values obtained for the TPC are in good agreement with the ones reported by other authors when levels between 30 and 70 mg/g were reported [58][59][60][61]. The high value obtained in the present study are for the lyophilized extract in ethanol/water.…”

Section: Discussionsupporting

confidence: 93%

White Grape Pomace Valorization for Remediating Purposes

et al. 2022

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The present investigation focuses on a possible alternative to reduce grape pomace’s negative impact on the environment by exploiting its capacities for wastewater remediation. Therefore, three directions are followed: (1) the characterization of white grape byproducts’ antioxidant and antiradical properties; (2) the determination of organophosphorus compound concentration that might be present in the samples; and (3) the evaluation of the possible use for wastewater remediation. The grape pomace was used for obtaining different extracts considering different extraction conditions. The hydroalcoholic extracts have an increased amount of total phenolic content. The lyophilized hydroalcoholic extract showed high total phenolic content (159.52 mg/100 g) and low organophosphorus content (0.257 ± 0.015 nmol). The lowest DPPH antiradical-scavenging activities were obtained for the extracts in ethanol obtained from refrigerated pomace (0.055) and for dried pomace (0.045).

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Antioxidant Activity and Polyphenols Characterization of Four Monovarietal Grape Pomaces from Salento (Apulia, Italy)

Cited by 35 publications

References 56 publications

Tempranillo Grape Extract in Transfersomes: A Nanoproduct with Antioxidant Activity

Tempranillo Grape Extract in Transfersomes: A Nanoproduct with Antioxidant Activity

A Liposomal Formulation to Exploit the Bioactive Potential of an Extract from Graciano Grape Pomace

White Grape Pomace Valorization for Remediating Purposes

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