Antioxidant activity and spectroscopic data of isoxanthohomol oxime and related compounds

Potaniec, Bartłomiej; Grabarczyk, Małgorzata; Stompor, Monika; Szumny, Antoni; Zieliński, Paweł; Żołnierczyk, Anna K.; Anioł, Mirosław

doi:10.1016/j.saa.2013.09.018

Cited by 20 publications

(22 citation statements)

References 24 publications

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“…Chromogenic oxidizing agent (copper(II) neocuproine [Cu(II)-Nc]) is presently widely used for measurements of antioxidant capacity index for dietary polyphenols, flavonoids, and vitamins C and E. The method is based on the measurement of the developed absorbance at 450 nm of a stable copper(I) neocuproine complex [ 62 ]. In the presence of antioxidant molecules copper(II) was reduced to copper(I).…”

Section: Resultsmentioning

confidence: 99%

Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of FolkloricLannea coromandelicaUsingIn VitroandIn VivoAssays

Kumar

Jain

2015

Scientifica

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The aim of this study was to determine the impending antioxidant properties of different extracts of crude methanolic extract (CME) of leaves of Lannea coromandelica (L. coromandelica) and its two ethyl acetate (EAF) and aqueous (AqF) subfractions by employing various established in vitro systems and estimation of total phenolic and flavonoid content. The results showed that extract and fractions possessed strong antioxidant activity in vitro and among them, EAF had the strongest antioxidant activity. EAF was confirmed for its highest phenolic content, total flavonoid contents, and total antioxidant capacity. The EAF was found to show remarkable scavenging activity on 2,2-diphenylpicrylhydrazyl (DPPH) (EC50 63.9 ± 0.64 µg/mL), superoxide radical (EC50 8.2 ± 0.12 mg/mL), and Fe2+ chelating activity (EC50 6.2 ± 0.09 mg/mL). Based on our in vitro results, EAF was investigated for in vivo antioxidant assay. Intragastric administration of the EAF can significantly increase levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) levels, and decrease malondialdehyde (MDA) content in the liver and kidney of CCl4-intoxicated rats. These new evidences show that L. coromandelica bared antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of FolkloricLannea coromandelicaUsingIn VitroandIn VivoAssays

Kumar

Jain

2015

Scientifica

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“…[80] (Table 5). The same study showed that a conversion of isoxanthohumol 502 into its oxime derivative increased its antioxidant activity by 503 about 200 times [22] (Fig. 4).…”

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confidence: 79%

Isoxanthohumol — Biologically active hop flavonoid

et al. 2015

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“…Moreover, its O -alkyl derivatives are also found in rice leaves, e.g., sakuranetin (7- O -methylnaringenin) [ 25 ], or plants from the Boraginaceae family, e.g., 7,4′-di- O -methylnaringenin and 5- O -methylnaringenin [ 26 ]. Due to a wide range of its biological properties, such as antioxidative [ 27 ], anticancerogenic [ 28 ], antibacterial [ 29 ], or antifungal activity [ 30 ], naringenin and its derivatives are popular among the scientific community [ 31 ]. The chemical modification of naringenin and its O -alkyl derivatives, consisting of the incorporation of an oxime group, could enhance their antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial O-Alkyl Derivatives of Naringenin and Their Oximes Against Multidrug-Resistant Bacteria

et al. 2020

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New antimicrobial agents are needed to address infections caused by multidrug-resistant bacteria. Here, we are reporting novel O-alkyl derivatives of naringenin and their oximes, including novel compounds with a naringenin core and O-hexyl chains, showing activity against clinical strains of clarithromycin-resistant Helicobacter pylori, vancomycin-resistant Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, and beta-lactam-resistant Acinetobacter baumannii and Klebsiella pneumoniae. The minimum inhibitory concentrations (MICs), which provide a quantitative measure of antimicrobial activity, were in the low microgram range for the selected compounds. Checkerboard assays for the most active compounds in combination with antibiotics revealed interactions that varied from synergistic to neutral.

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Antioxidant activity and spectroscopic data of isoxanthohomol oxime and related compounds

Cited by 20 publications

References 24 publications

Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of FolkloricLannea coromandelicaUsingIn VitroandIn VivoAssays

Appraisal of Total Phenol, Flavonoid Contents, and Antioxidant Potential of FolkloricLannea coromandelicaUsingIn VitroandIn VivoAssays

Isoxanthohumol — Biologically active hop flavonoid

Antimicrobial O-Alkyl Derivatives of Naringenin and Their Oximes Against Multidrug-Resistant Bacteria

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