Antioxidant activity and total phenolic content of methanol extracts of<i>Ixora coccinea</i>

Torey, Angeline; Sasidharan, Sreenivasan; Latha, Lachimanan Yoga; Sudhakaran, Sivaramakrishnan; Ramanathan, Surash

doi:10.3109/13880200903490505

Cited by 43 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The xanthine oxidase inhibition assay was done according to the method previously described by Cos et al [12] and Torey et al [13] . The uric acid production was calculated according to the increasing absorbance at 290 nm.…”

Section: Xanthine Oxidase Inhibition Assaymentioning

confidence: 99%

Antioxidant activity of methanol extracts of different parts of Lantana camara

Mahdi-Pour

Jothy

Latha

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

Self Cite

186

View full text Add to dashboard Cite

Section: Xanthine Oxidase Inhibition Assaymentioning

confidence: 99%

Antioxidant activity of methanol extracts of different parts of Lantana camara

Mahdi-Pour

Jothy

Latha

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

Self Cite

186

View full text Add to dashboard Cite

“…Flowers are applied externally to sores, employed for chronic ulcer, scabies and some type of dermatitis and also used internally for cholera, diarrhea, dysentry, leucorrhea, antitumor and gonorrhea, fresh juice of flower have protective action against electroconvulsions. [1–3] Ixora coccinea Linn. flowers showed chemoprotective effects on cyclophosphamide-induced toxicity by increasing the life span of treated mice[4] and also on cisplatin-induced toxicity.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats

Momin¹,

Kalai²,

Shikalgar³

et al. 2012

Indian J Pharmacol

View full text Add to dashboard Cite

Objectives:To investigate the effect of methanolic extract of Ixora coccinea Linn. (MEIC) leaves against doxorubicin-induced cardiac toxicity in rats.Material and Methods:Albino Wistar rats were pretreated with the methanolic extract of Ixora coccinea Linn. leaves (200 and 400 mg/kg, orally) for 1 week followed with the simultaneous treatment with doxorubicin (cumulative dose of 15 mg/kg in six divided doses for 2 weeks) along with the extracts for the next 14 days. On the 22nd day hemodynamic parameters such as blood pressure and ECG were recorded. Biochemical study including biomarkers like creatine kinase – MB (CK – MB), lactate dehydrogenase (LDH), SGOT and SGPT, tissue antioxidant markers viz. catalase (CAT), superoxide dismutase (SOD) and extent of lipid peroxidation viz. malondialdehyde (MDA) was estimated. Histopathology of heart was also done to assess the cardioprotective effect.Results:Pretreatment with MEIC significantly reduced (P<0.01) the ST segment elevation and also maintained the BP (P<0.01) close to normal. The MEIC significantly reduced the elevated level of biomarkers like CK - MB, LDH, SGOT, SGPT (P<0.01) near to normal, the MEIC also increased the tissue antioxidant markers viz. CAT, SOD and decreased the level of MDA (P<0.01) in cardiac tissue by dose-dependant manner. The histopathology of heart also further confirmed the cardioprotection provided by the methanolic extract of Ixora coccinea Linn. leaves.Conclusion:The results suggest a cardioprotective effect of Ixora coccinea Linn. leaves due to its antioxidant properties.

show abstract

“…Both activities are the first records of these isolated compounds from the flowers of Ixora coccinea Linn. such as antimicrobial (Annapurna et al 2003), antioxidant (Saha et al 2008;Torey et al 2010), cytotoxic, antitumour (Latha and Pannikkar, 1998) hepatoprotective (Latha et al 2003;Shyamal et al 2010), anti-inflammatory (Ratnasooriya et al 2005). Recently we have been reported the cardiovascular effect of I. coccinea flowers (Rahman et al 2012) and its isolated pure compounds, which belong to terpenoids, steroids, steroidal glycosides, tannins, polyphenols and sugars (Versiani et al 2012;Ikram et al 2013).…”

mentioning

confidence: 99%

New dammarane and ursane-type triterpenoids from the flower ofIxora coccineaLinn.

Ikram

Versiani

Khatoon

et al. 2015

Natural Product Research

View full text Add to dashboard Cite

Two new esters of dammarane triterpenoids ixorene isovalerate (1), ixorene 3',8'-dimethyloctanoate (2) and a new ursane-type triterpenoids Ixoroid acid (3) were isolated from the methanolic extract of flowers of Ixora coccinea Linn., along with the three known constituents. The structures of compounds 1 and 3 were elucidated on the basis of extensive 1D,2D NMR studies and mass spectrometry as 17β-dammara-12,20-diene-3β-isovelarate and 3β-hydroxy-18β-urs-12ene-29β-oic acid, respectively, whereas 2 was identified as 17β-dammara-12,20-diene-3β-3',8'-dimethyloctanoate through (1)H NMR and mass spectral data. Compounds 1, 2, 4 and 5 were evaluated for their in vitro cytotoxic activity, which exhibited weak activity against the 3T3, PC3 and HeLa cell lines with the IC50 value >30 μM. Antioxidant results of 1 - 5 revealed that only compound 5 showed antioxidant activity in DPPH radical scavenging inhibition with the IC50 1.31 × 10(- 6) ± 0.005 μm mL(- 1). Both activities are the first records of these isolated compounds from the flowers of Ixora coccinea Linn.

show abstract

Antioxidant activity and total phenolic content of methanol extracts ofIxora coccinea

Cited by 43 publications

References 28 publications

Antioxidant activity of methanol extracts of different parts of Lantana camara

Antioxidant activity of methanol extracts of different parts of Lantana camara

Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats

New dammarane and ursane-type triterpenoids from the flower ofIxora coccineaLinn.

Contact Info

Product

Resources

About