Antioxidant Activity of Carvone and Derivatives against Superoxide Ion

Pombal, Sofia; Hernández, Yaiza; Dı́ez, David; Mondolis, Eily; Mero, Aldahir; Morin-Pinzón, Juan; Guerrero, Estela; Rodilla, Jesús M.

doi:10.1177/1934578x1701200502

Cited by 19 publications

(15 citation statements)

References 17 publications

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“…The antioxidant activity of A. polystachya essential oil is likely due to the high oxygenated monoterpene content [ 19 ], under which carvone is most representative [ 20 ]. Carvone is an oxygenated monoterpene with a double bond conjugated with a ketone group, which gives it greater capacity to capture free radicals and better reducing power [ 20 , 21 , 22 , 23 ]. Indeed, high carvone content has been linked to antioxidant activity in Mentha spicata and M. gracilis essential oils [ 24 ], as well as in essential oils of different species of the Verbenaceae family like Lippia alba and Phyla nodiflora [ 22 , 25 , 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile

et al. 2020

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The aim of this study was to determine, first, the chemical composition of Aloysia polystachya (Griseb) Moldenke essential oil, from leaves harvested in central Chile; and second, its antioxidant and cytotoxic activity. Eight compounds were identified via gas chromatography–mass spectrometry (GC–MS) analyses, with the most representative being R-carvone (91.03%), R-limonene (4.10%), and dihydrocarvone (1.07%). For Aloysia polystachya essential oil, antioxidant assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2, ferric reducing antioxidant power (FRAP), and total reactive antioxidant potential (TRAP)) showed good antioxidant activity compared to commercial antioxidant controls; and anti-proliferative assays against three human cancer cell lines (colon, HT-29; prostate, PC-3; and breast, MCF-7) determined an IC50 of 5.85, 6.74, and 9.53 µg/mL, and selectivity indices of 4.75, 4.12, and 2.92 for HT-29, PC-3, and MCF-7, respectively. We also report on assays with CCD 841 CoN (colon epithelial). Overall, results from this study may represent, in the near future, developments for natural-based cancer treatments.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile

et al. 2020

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“…In DPPH• scavenging assays, similar antioxidant activity to the reference compound ascorbic acid (21.4%) was observed for carvone (25.9%) and its chloro derivative (22.6%). On the other hand in NO• scavenging assays, carvone and its derivative showed much lower antioxidant activity (13.24% and 14.08%, respectively) as compared to reference curcumin (24%) 113 …”

Section: Carvonementioning

confidence: 86%

A review on dill essential oil and its chief compounds as natural biocide

Kaur

Bhardwaj

2020

Flavour & Fragrance J

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Anethum graveolens L. (dill), a member of Umbelliferae family, is an important essential oil‐bearing herb native to the Mediterranean and West Asia. It is well documented for its medicinal and traditional uses. The chemical composition of dill seed essential oil showed the presence of numerous volatile compounds with carvone, limonene, α‐phellandrene, β‐phellandrene and p‐cymene being the major ones in almost all its aerial parts. Thus, the main focus of this updated review is to highlight the biological importance of dill essential oil and its major constituents (carvone and limonene) reported till date. Although the number of reviews has been published on its chemical composition and medicinal uses, its role in the field of agriculture to develop commercial formulations is still needed to be explored. In brief, the information presented in this review will be useful in creating interest in the use of dill essential oil and its major constituents for the development of commercial plant‐based pesticides.

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“…The mean IC 50 values of samples (1-8) were 175.2, 310.5, 169.5, 221.5, 165.5, 195.0, 225.0, and 165.5 µg/mL respectively, which were compared with the standard antioxidant rutin (IC 50 2.93 µg/mL). The potential antioxidant activity exhibited by the essential oil may be due to the presence of a variety of chemical compounds like β-caryophyllene [36,37], (E)-cinnamaldehyde [38], carvacrol [39], carvone [40], cembrene [41], eugenol [42], methyl palmitate, palmitic acid, oleic acid [28,43], α-copaene [44], α-himachalene [45], α-humulene [46], α-terpineol [47], and δ-cadinene [48] which are present in the these samples. All these compounds are collectively responsible for antioxidant activity.…”

Section: The Antioxidant Activitymentioning

confidence: 99%

Volatile Composition and Biological Activity of Jordanian Commercial Samples of R. coriaria L. Fruits

et al. 2021

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The present paper reports the GC-HS-SPME analysis of volatile emission and GC-MS analysis of chemical composition of essential oil of R. coriaria fruits of eight different samples of R. coriaria L. fruits (“sumac” folk name), collected from Jordanian agricultural field and the local market. The analyses show an important variability among the Sumac samples probably due to the origin, cultivation, harvesting period, drying, and conservation of the plant material. The main class of component present in all samples was monoterpenes (43.1 to 72.9%), except for one sample which evidenced a high percentage of sesquiterpene hydrocarbons (38.5%). The oxygenated monoterpenes provided a contribution to total class of monoterpenes ranging from 10.1 to 24.3%. A few samples were rich in monoterpene hydrocarbons. Regarding the single components present in all the volatile emissions, β-caryophyllene was the main compound in most of the analyzed samples, varying from 34.6% to 7.9%. Only two samples were characterized by α-pinene as the main constituent (42.2 and 40.8% respectively). Essential oils were collected using hydro-distillation method. Furfural was the main constituent in almost all the analyzed EOs (4.9 to 48.1%), except in one of them, where β-caryophyllene was the most abundant one. β-caryophyllene ranged from 1.2 to 10.6%. Oxygenated monoterpenes like carvone and carvacrol ranged from 3.2–9.1% and 1.0–7.7% respectively. Cembrene was present in good amount in EO samples EO-2 to EO-8. The antioxidant capacities of the fruit essential oils from R. coriaria were assessed using spectrophotometry to measure free radical scavenger 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and inhibition of β-carotene bleaching (BCB). The essential oils from the fruits of the different samples of R. coriaria exhibited the MIC value ranging from 32.8 to 131.25 µg/mL against S. aureus ATCC 6538 and 131.25 to 262.5 µg/mL against E. coli ATCC 8739. The MIC values of ciprofloxacin were 0.59 and 2.34 µg/mL against S. aureus ATCC 6538 and E. coli ATCC 8739, respectively.

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Antioxidant Activity of Carvone and Derivatives against Superoxide Ion

Cited by 19 publications

References 17 publications

Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile

Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile

A review on dill essential oil and its chief compounds as natural biocide

Volatile Composition and Biological Activity of Jordanian Commercial Samples of R. coriaria L. Fruits

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