Antioxidant activity of hydrazones with sterically hindered phenol fragments

Nikolaevskii, A. N.; Kniga, O. P.; Khizhan, E. I.; Tikhonova, G. A.; Vinogradov, Vladimir V.; Khizhan, A. I.

doi:10.1134/s0036024412120205

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Hydrazones are considered as important class of organic compounds possessing diverse biological activities like analgesic [4], anti-inflammatory [5], anticancer [6], antimicrobial [6,7], antibacterial [8], vasodilative [9] and antioxidant activity [10]. Some investigations have proved that the structural characteristics of aroylhydrazones turn them into promising candidates for the development of novel synthetic antioxidants retarding the cellular damage induced by free radicals [11,12]. Aroylhydrazones derived from salicylaldehyde are biologically active molecules and one of the most interesting compounds is salicylaldehyde benzoylhydrazone (SBH) which has been proved to inhibit the process of DNA synthesis and cell growth of malignant cells in vitro and in vivo [6,13].…”

Section: Introductionmentioning

confidence: 99%

3-methoxy aroylhydrazones – free radicals scavenging, anticancer and cytoprotective potency

et al. 2017

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Section: Introductionmentioning

confidence: 99%

3-methoxy aroylhydrazones – free radicals scavenging, anticancer and cytoprotective potency

et al. 2017

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“…Azomethine group (-NH-N=CH-) contained in their structure is connected with carbonyl group and is responsible for the different pharmacological applications of cited compounds. Hydrazid-hydrazones have, therefore, attracted considerable attention to their wide range of biological activities (Sarıgöl et al 2015), including antioxidant, anticancer and cytoprotective potency (Hristova-Avakumova et al 2017;Nikolaevskii et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives

Mitkov¹,

Kondeva-Burdina²,

Zlatkov³

2019

PHAR

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New series of caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives were designed and synthesized. The targed compounds were obtained in yields of 51 to 96% and their structures were elucidated by FTIR, 1H NMR, 13C NMR, MS and microanalyses. All of the compounds were found to be “drug-like” as they fulfill the criteria of drug-likeness, which includes the MDDR-like rule. The tested compounds were subjected to in silico prediction of substrate/metabolite specificity and Drug Induced Liver Injury (DILI). The prediction for indicated that the evaluated compounds would most probably act as CYP1A2 substrates. The performed in vitro studies didn’t reveal statistically significant hepatotoxicity of the tested compounds, probably due to the pro-oxidant effects expressed on sub-cellular (isolated rat liver microsomes) level. The obtained experimental results confirmed the predicted low hepatotoxicity for the tested structures. Based on these results the compounds may be considered as promising structures for design of future molecules with low hepatotoxicity.

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Hydrazone analogs as DNA gyrase inhibitors and antioxidant agents: Structure-activity relationship and pharmacophore modeling

Dammene Debbih,

Mazouz,

Benslama

et al. 2024

J Chem Sci

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Antioxidant activity of hydrazones with sterically hindered phenol fragments

Cited by 5 publications

References 8 publications

3-methoxy aroylhydrazones – free radicals scavenging, anticancer and cytoprotective potency

3-methoxy aroylhydrazones – free radicals scavenging, anticancer and cytoprotective potency

Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives

Hydrazone analogs as DNA gyrase inhibitors and antioxidant agents: Structure-activity relationship and pharmacophore modeling

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