Antioxidant activity of<i>Citrus limon</i>essential oil in mouse hippocampus

Campêlo, Lidianne Mayra Lopes; Gonçalves, Fabrício Custódio de Moura; Feitosa, Chistiane Mendes; Freitas, Rivelilson Mendes de

doi:10.3109/13880209.2010.541924

Cited by 49 publications

(27 citation statements)

References 43 publications

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“…Furthermore, it also possessed scavenger activity in all in vitro tests [70].Essential oil of Citrus limon leaves reduced the lipid peroxidation and nitrite content as well as increase the glutathione reduced (GSH) levels and enzymatic antioxidant activities (super-oxide dismutase, catalase and glutathione peroxidase) in mice hippocampus. These findings strongly support the hypothesis that oxidative stress in hippocampus might occur during neurodegenerative diseases, proving that hippocampal damage induced by the oxidative process played a crucial role in brain disorders, which implies that a neuroprotective effect could be achieved using Citrus limon essential oil as antioxidant treatment [71].The action of Citrus limonum essential oil to control free radicalinduced lipid peroxidation and preventing tissue damage in skin was investigated. The superoxide anion scavenging activity of essential oil was evaluated by the enzymatic hypoxanthine/xanthine oxidase system.…”

Section: Citrus Speciessupporting

confidence: 71%

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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Previous studies showed that a wide range of medicinal plants exerted antioxidant and free radical scavenging activity. These plants included: Cicer arietinumThe free radicals scavenging, antioxidant properties and intestinal α-glucosidase inhibitory activity of methanol extract of two varieties of Cicer arietinum were evaluated. Compared with raw seeds increase in total polyphenol and flavonoids concentration in green gram sprouts and Kabuli Chana sprouts (KCs) were recorded. Total protein concentrations in sprouts did not differ from non-sprouted grains. 2,2'-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) cation scavenging activity was more than twice in Bengal gram sprouts of (BGs) and KCs than their raw seeds. 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide scavenging, nitro blue tetrazolium reducing and glucose-induced Hb-glycation inhibitory activity did not differ from non-sprouted raw grains. Increase in rat intestinal α-glucosidase inhibitory activity was observed in BGs and KCs. BGs significantly mitigated first 30 min starch-induced postprandial glycemic excursions and reduced 2 h postprandial glycemic load [44][45].The extent of free radical scavenging properties and antioxidant effects of crude extracts of sprouted Cicer arietinum (Chick pea/Chana/Bengal gram) seeds were evaluated. Two main varieties of Cicer arietinum seeds viz. Kabuli-Chana (cream seed-coat) and Bengal gram (brown seed-coat) were examined and compared for their free radical scavenging properties and antioxidant effects. Free radical scavenging properties were evaluated against stable 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) and hydrogen peroxide radical and the Medicinal plants with antioxidant and free radical scavenging 63 extent of antioxidant effect was assessed by lipid peroxidation induced by ferrous sulphate on the lipid present in the liver homogenate. The results showed that the two Cicer arietinum extracts were differed in their capacities to quench or inhibit DPPH, hydrogen peroxide and lipid peroxide. Brown colored Cicer arietinum sprouts showed the greatest activity against DPPH radicals, hydrogen peroxide radicals and lipid peroxide compared to the cream variety [45][46].The root of Cicer arietinum was extracted using solvents of different polarities and explored for in vitro free radical scavenging activity. Preliminary assays of three different extracts of Cicer arietinum root showed that the extracts possess electron donating ability and reduction of ferric ion to ferrous in a cell free system at pH-7.4. It has also been found from total antioxidant capacity as assessed by reduction of molybdate showed Cicer arietinum root extracts to possess (standard) ascorbic acid equivalents per milligrams of the extracts. Hydroalcoholic root extract was found more effective when compared to alcoholic and water extracts in scavenging 1, 1-diphenyl-2-picrylhydrazyl, reducing ferric ion and molybdate reduction in antioxidant capacity. A significant correlations exist between extract concentrations and percentage scaveng...

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Section: Citrus Speciessupporting

confidence: 71%

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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“…Nerolidol (NRD) was identified as one of the major bioactive compounds in essential oils and is a naturally occurring sesquiterpene found in many plants such as Baccharis dracunculifolia (Botelho et al, 2007), Amaranthus retroflexus (Klopell et al, 2007), and Canarium schweinfurthii and is also present in flowers, like neroli, jasmine, ginger lavender, and tea tree (Pacifico et al, 2008). NRD is a leading compound whose metabolites was shown to exhibit antioxidant (Nogueira Neto et al, 2013), antiinflammatory (Fonseca et al, 2016), antidepressant (Campelo, Gonçalves, Feitosa, & de Freitas, 2011), anticonvulsant (Costa, Ferreira, De Sousa, Jordan, & Freitas, 2012), analgesic (De Sousa et al, 2009, and anxiolytic (De Almeida, Costa, de Carvalho, de Sousa, & de Freitas, 2012) properties. There is no report for cardioprotective effect of NRD in ISO induced rats earlier.…”

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confidence: 99%

Expression of Concern: Preventive effect of nerolidol on isoproterenol induced myocardial damage in Wistar rats: Evidences from biochemical and histopathological studies

Asaikumar

Vennila

Akila

et al. 2019

Drug Development Research

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The present study aimed at investigating the protective effects of nerolidol (NRD) against myocardial infarction (MI) induced by isoproterenol (ISO) in Wistar rats. The rats were randomly divided into five groups, each group consisting of six rats. Group I were treated as control rats, group II received NRD (200 mg/kg b.w.) by intragastric intubation for 21 days, group III received ISO (60 mg/kg b.w) subcutaneously (s.c) for two consecutive days on 22nd and 23rd day, group IV and V received NRD (100 and 200 mg/kg b.w) as in group II and additionally ISO was given for two consecutive days (22nd and 23rd). On 24th day all the rats were sacrificed by cervical dislocation and the blood and heart samples were collected. In the present study, ISO‐induced myocardial damage was indicated by the changes in body weight, heart weight and the cardiac and hepatic marker enzymes such as creatine kinase (CK), creatine kinase‐MB (CK‐MB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and troponin T and I (cTnT, cTnI) in the serum. In addition, the levels of lipid peroxidation products such as thiobarbituric acid reactive substances (TBARS), conjugated dines (CD), and lipid hydroperoxides (LHPs) increased significantly in the plasma and heart tissue. Activities of enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST) in erythrocytes and heart tissue and the levels of nonenzymatic antioxidants like vitamin C, vitamin E, and reduced glutathione (GSH) in plasma and heart tissue were decreased in ISO‐induced rats. Histopathological observations were also supported with the biochemical parameters. Pretreatment with NRD at different doses (100 and 200 mg/kg b.w) for 21 days prevented the above changes induced by ISO. The 200 mg/kg b.w of NRD was more pronounced than the other dose and brought back all the above parameters near to normalcy.

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“…structures from lemon peels was established (Matsubara et al 1990). At the same time, some researchers have also investigated the role of induced cells apoptosis (Ogata et al 2000), hepatoprotective capacity (Bhavsar et al 2007), antimicrobial properties (Lopes Campêlo et al 2011;Agarwal et al 2012) and antinociceptive effects of C. limon fruit extract . Even these abovementioned works have concerned about lemon, however, these studies mainly focused on identifying individual phenolic compounds and evaluating one specific bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Characterization of phenolic profile and antioxidant capacity of different fruit part from lemon (Citrus limon Burm.) cultivars

Qun³

2017

J Food Sci Technol

125

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Phenolic composition and antioxidant capacity of different fruit part including peel, pulp, juice, whole fruit and seed from five lemon cultivars (Feiminailao, Cuningmeng Limeng, Pangdelusaningmeng, Beijingningmeng) were investigated. Caffeic acid (9.31-741.4 lg/g FW) and chlorogenic acid (2.7-527.5 lg/g FW) were the dominant phenolic acid in fruit tested, Pangdelusaningmeng (PD) and Limeng peels with the highest contents, respectively. Hesperidin was the predominant flavanone (10.27-3315 lg/g FW), Cuningmeng (CN) peels with the highest level. PD peels had rich rutin, CN seeds had rich eriocitrin. Nobiletin was the main polymethoxylated flavonoids identified, PD with the highest level. CN peels contained rich tangeretin. Overall, peels and whole fruit had significantly higher level of phenolics than other fruit parts, and seeds were good source of flavonoids. PD and CN not only contained higher level of phenolic, but also presented higher antioxidant capacity than other cultivars tested, and are of great value for human nutrition.

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Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Cited by 49 publications

References 43 publications

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

Expression of Concern: Preventive effect of nerolidol on isoproterenol induced myocardial damage in Wistar rats: Evidences from biochemical and histopathological studies

Characterization of phenolic profile and antioxidant capacity of different fruit part from lemon (Citrus limon Burm.) cultivars

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