Antioxidant and Anticancer Activity of Pulsed Electric Field Treated Grape Extract

Abstract

Plant products that are rich in antioxidant properties include grape, one of the world's largest fruit crops and most commonly consumed fruits in the world. Grape extract comprises several bio-active compounds, mostly represented by polyphenols and phenolic acids. It could be an excellent alternative to toxic chemo drugs, with minimal side effects and economical. Grape extract exerts high antioxidant and anticancer activities against cell lines. It could be used to treat a number of cancers, including lung, colon, cervical, bladder and prostate cancers. In this paper, the antioxidant and anticancer activity of pulsed electric field (PEF) treated grape extract is investigated. HeLa cell line (cervical cancer) was used for this purpose. The results indicate more cell death due to PEF-treated extract compared to untreated one, indicating the potency of PEF-treated extract. This shows the potential of using PEF-treated grape extract as a possible anti-cancer drug.

Enhancement of bioactive compounds from green grapes extract using pulsed electric field treatment

“…PEF treatment has been evidenced as a promising technology for enhancing the extraction of bioactive compounds and antioxidants. 4 PEF treatment is the application of high-frequency, electric pulses with high intensity field strengths, which can modulate the activity of biological membranes, which in turn enhances the bioactive compounds present in the food. 5 In this study, the amount of polyphenol and antioxidant activity of PEF treated and untreated grape extract is investigated.…”

Cytotoxicity Potential of Nelsonia canescens (Lam.) Spreng Extracts against Cervical Cancer Cell Lines

“…Invent of natural anticancer drugs paved a way for cancer treatment with no or less side effects. The use of natural extracts that we use in day to day life is an excellent alternative for chemical drugs used in cancer treatment [7].…”