Antioxidant and antimicrobial material by grafting of L-arginine onto enzymatic poly(gallic acid)

psoInhibition of proliferation, migration, and adhesion of skin fibroblasts by enzymatic poly(gallic acid) grafted with L-Arginine

“…The microwave-assisted grafting of L-Arg onto PGAL, including the synthesis of the latter, was carried out following a previously reported procedure (24). The proton nuclear magnetic resonance ( 1 H-NMR) spectra corroborated the molecular structure in a Varian MR-400 (USA) spectrometer in D 2 O; Fourier-transform infrared spectroscopy (FTIR) spectra were acquired in a Perkin-Elmer Attenuated Total Reflection (ATR) FTIR Spectrum-400 equipment.…”

“…The proton nuclear magnetic resonance ( 1 H-NMR) spectra corroborated the molecular structure in a Varian MR-400 (USA) spectrometer in D 2 O; Fourier-transform infrared spectroscopy (FTIR) spectra were acquired in a Perkin-Elmer Attenuated Total Reflection (ATR) FTIR Spectrum-400 equipment. Size exclusion chromatography (SEC) was used to assess the average molecular weight following the earlier reported procedure (24), providing a molecular weight in number ( ) of 7.3 kDa for the PGAL-g-L-Arg sample used in this work.…”

“…A fish model for wound healing has shown that a diet with L-Arg improves wound closure, decreases the expression of the pro-inflammatory tumor necrosis factor (TNF-α), and increases the expression of the transforming growth factor β1 (TGF-β1), which is related to tissue regeneration (23), these characteristics are desirables for a medicine to treat the lesions in psoriasis and AD. L-Arg is readily grafted onto PGAL (PGAL-g-L-Arg) to improve the biological characteristics with potential anti-bactericidal and antioxidant activities as recently demonstrated (24). The anti-bacterial capacity of PGAL-g-L-Arg is also desired in the treatment of psoriasis and AD since the infections could increase the inflammation and the size of the lesions of the skin.…”

Synthesis and antimicrobial activity of aminoalkyl resveratrol derivatives inspired by cationic peptides

“…Mangostin and kaempferol-based mimetics of cationic antimicrobials have also been developed with promising activity in a murine corneal infection study 14 , 16 , 17 . Recently, materials based on arginine-substituted poly(gallic acid) have been described and showed antimicrobial activity against both Gram-negative and Gram-positive bacteria 18 . Besides, cationic amino resveratrol (RES) derivatives, imine-RES, or aza-RES analogues have been prepared for different therapeutic uses, such as neurodegenerative diseases, 19 cancer 20–25 , or inflammation 16 , 17 .…”