Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats

Konda, Venu Gopala Rao; Eerike, Madhavi; Raghuraman, Lakshmipathy Prabhu; Rajamanickam, Maignana Kumar

doi:10.7860/jcdr/2016/10798.7388

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…The extracts of wild rhizomes showed radical scavenging activity that was less than all standards at all concentrations, but methanolic extracts showed scavenging activity almost comparable to standards (BHT and OH − ). Our findings are comparable to those of earlier research [ 68 , 69 , 70 ]; in radical scavenging tests, the antioxidant effect of several plant extracts was investigated. The phenolic compounds in plant extracts may be responsible for the effect.…”

Section: Discussionsupporting

confidence: 92%

Phytochemical Screening, Antioxidant and Antifungal Activities of Aconitum chasmanthum Stapf ex Holmes Wild Rhizome Extracts

Rafiq

Wagay²,

Elansary

et al. 2022

Antioxidants

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Aconitum chasmanthum Stapf ex Holmes, an essential and critically endangered medicinal plant from Kashmir Himalayas, was studied for its antioxidant and antifungal properties. The shade-dried powdered rhizome was extracted sequentially with hexane, ethyl acetate, and methanol. These subsequent fractions were evaluated for total phenolic content (TPC); total flavonoid content (TFC); antioxidant assays, such as 1,1-diphenyl 1-2-picryl-hydrazyl (DPPH); ferric-reducing antioxidant power (FRAP); superoxide radical scavenging (SOR); hydroxyl radical scavenging (OH) and antifungal activity using the poisoned food technique. Highest TPC (5.26 ± 0.01 mg/g) and TFC (2.92 ± 0.04 mg/g) were reported from methanolic extracts. The highest values of radical scavenging activities were also observed in methanolic extracts with IC50 values of 163.71 ± 2.69 μg/mL in DPPH, 173.69 ± 4.91 μg/mL in SOR and 159.64 ± 2.43 μg/mL in OH. The chemical profile of ethyl acetate extract was tested using HR-LCMS. Methanolic extracts also showed a promising inhibition against Aspergillus niger (66.18 ± 1.03), Aspergillus flavus (78.91 ± 1.19) and Penicillium notatum (83.14 ± 0.97) at a 15% culture filtrate concentration with minimum inhibitory concentration (MIC) values of 230 μg/mL, 200 μg/mL and 190 μg/mL, respectively. Overall, the methanolic fractions showed significant biological potential, and its pure isolates might be used to construct a potential new medicinal source.

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Section: Discussionsupporting

confidence: 92%

Phytochemical Screening, Antioxidant and Antifungal Activities of Aconitum chasmanthum Stapf ex Holmes Wild Rhizome Extracts

Rafiq

Wagay²,

Elansary

et al. 2022

Antioxidants

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“…The released iron makes a complex with gentamicin and accelerates the oxidative stress [22]. Among the main approaches used to ameliorate or protect the gentamicin-induced nephrotoxicities, the most consistent effects have been observed with the use of antioxidant agents [23]. Some antioxidant agents that have been used to ameliorate gentamicin-induced nephrotoxicity in rats include deferoxamine, methimazole, vitamin E, vitamin C diethyl dithiocarbamate, L-histidinol, thymoquinone [24].…”

Section: Discussionmentioning

confidence: 99%

Evaluation for Nephroprotective Activity of Ethanolic Extract of Allium Cepa Linn. In Gentamicin-Induced Nephrotoxicity in Rats

Elsani

Chinnala²,

Achanta³

et al. 2017

Asian J Pharm Clin Res

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Objective: Kidney diseases are a major problem of worldwide proportions, and renal damage is very common since kidney has the capacity to excrete toxic substances. This study aimed to evaluate the protective effect of the ethanolic extract of Allium cepa Linn. (EEAC) plant leaves against gentamicininduced nephrotoxicity in rats.Methods: Nephroprotective activity was estimated by inducing gentamicin (100 mg/kg) to all the groups of animals; acute kidney dysfunction is an evidenced by significant elevation of serum creatinine, total protein and decreased body weight with multiple histological damages. Results:Treatment with the A. cepa Linn. has shown significant (p<0.01 and p<0.001) dose-dependent improvement in the body weight at the dose of 200 and 400 mg/kg and also shown significant improvement by protecting the kidney from the oxidative stress. It is also identified that treatment with A. cepa significantly lowered the level of serum creatinine, total protein when compared with the toxic group. Conclusion:Nephroprotective activity of EEAC treatment was found compared with the standard group (Vitamin E -250 mg/kg) and control group against the toxic control group animals in parameters including serum creatinine, total protein, kidney weights, and body weights. The histopathological studies were also evinced the protective effect of EEAC.

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“…A range of studies are available on the alpine plants' antioxidant potential [56, 57, 58, 69] and revived by Bhatt et al [70]. Alpine plants from the Himalayan region are most remarkable for their medicinal properties plants like Picrorhiza kurrooa [71,72] Aconitum sp. [72,73], Polygonum bistorta [73,74] Nardostachys jatamansi [75], etc.…”

Section: Alpine Plants Antioxidant and Medicinal Importancementioning

confidence: 99%

Antioxidant Properties of Alpine Plant

Trivedi¹,

Nautiyal²

2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Alpines are the exceptional regions of the world’s biomes. They have unique climatic and topographic conditions; they are the habitat of some of the highly specialized flora and fauna. The harsh environmental conditions and extreme fluctuations in them on a seasonal and diurnal basis created extremely stressful situations for the alpine plants. Such stress causes damage to biochemical structures and compounds of the plant cells leads to the production of free radicals, i.e. reactive oxygen species (ROS), which can further damage the plant cells or tissues. Alpine plants protect themselves from those ROS efficiently by their highly competent enzymatic and non-enzymatic antioxidant system. In general, this protection increases in alpine plants with altitudes; however, some exceptions are also reported. Antioxidant compounds viz. ascorbic acid, tocopherol, glutathione, carotenoids found in alpine flora in higher concentrations as compared to low land plants. Phenolic compounds protected the alpine plants from UV induced ROS by screening the UV radiations and blocking their entries in the cell’s mesophyll. This higher antioxidant potential of the alpine plants is highly beneficial for the human being as most alpine plants are the sources of some life-saving drugs.

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Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats

Cited by 10 publications

References 30 publications

Phytochemical Screening, Antioxidant and Antifungal Activities of Aconitum chasmanthum Stapf ex Holmes Wild Rhizome Extracts

Phytochemical Screening, Antioxidant and Antifungal Activities of Aconitum chasmanthum Stapf ex Holmes Wild Rhizome Extracts

Evaluation for Nephroprotective Activity of Ethanolic Extract of Allium Cepa Linn. In Gentamicin-Induced Nephrotoxicity in Rats

Antioxidant Properties of Alpine Plant

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