Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon

El‐Demerdash, Fatma M.; Nasr, Hoda M.

doi:10.1016/j.jtemb.2013.10.001

Cited by 117 publications

(60 citation statements)

References 43 publications

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“…Renal dysfunction was clearly evidenced in CPF and ABM and CPF+ABM-treated groups as revealed by the elevation in serum urea and creatinine (Table 1). In agreement with the previous studies, renal dysfunction was occasioned in animals treated with ABM, methomyl, and diazinon insecticides (Eissa and Zidan 2009;El-Demerdash et al 2013;El-Demerdash and Nasr 2014). The increase in urea concentration in the current study may be due to its effect on liver function (data not shown), as urea is the end-product of protein catabolism, and/or referred to kidney dysfunction.…”

Section: Discussionsupporting

confidence: 92%

Neuro and renal toxicity induced by chlorpyrifos and abamectin in rats

Nasr

El‐Demerdash

El-Nagar

2015

Environ Sci Pollut Res

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Oxidative stress by increased production of reactive oxygen species has been implicated in pesticides toxicity. This study focused on the toxicological effects of chlorpyrifos, an organophosphate insecticide and abamectin, a biocide each alone or in combination on antioxidant status, and oxidative stress biomarkers in brain and kidney. Animals were divided into four groups. The first group was used as control while groups 2, 3, and 4 were treated with chlorpyrifos (CPF; 14.9 mg/kg BW), abamectin (ABM; 30 mg/kg BW), and chlorpyrifos plus abamectin, respectively. Rats were treated daily with the tested compounds by oral gavages for 30 days. Results revealed that thiobarbituric acid-reactive substances (TBARS) levels were significantly increased in brain and kidney due to insecticides administration. On the other hand, reduced glutathione (GSH) and protein contents in addition to the activities of antioxidant enzymes, alkaline phosphatase (ALP), and acetylcholinesterase (AChE) were significantly decreased in rat organs. A significant induction in lactate dehydrogenase (LDH) activity, urea, and creatinine levels were also observed. The response was more pronounced in rats treated with both CPF and ABM. Results showed that the used insecticides had the propensity to cause significant oxidative damage in rat brain and kidney which is associated with marked perturbations in antioxidant defense system. It can be concluded that antioxidant enzymes can be used as potential biomarkers of toxicity associated with pesticides exposure.

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Section: Discussionsupporting

confidence: 92%

Neuro and renal toxicity induced by chlorpyrifos and abamectin in rats

Nasr

El‐Demerdash

El-Nagar

2015

Environ Sci Pollut Res

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“…These results are consistent with the literature and point towards the role of ROS in DZN-mediated injury and toxicity. The insecticide, diazinon was reported to increase serum urea and creatinine, urinary glucose, and renal tissue MDA, while antioxidant markers were decreased in rats and mice (Boroushaki et al 2013;Cakici and Akat 2013;El-Demerdash and Nasr 2013). Long term administration of diazinon in rabbits induced significant oxidative DNA damage in the liver and kidney and significantly reduced plasma CAT, GSH and TAC levels (Tsitsimpikou et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

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Diazinon (DZN) is a synthetic organophosphrus acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid-vitamin C against DZN-induced renal injury in male Wistar albino rats. DZN-treated animals revealed significant elevation in serum biochemical parameters related to renal injury: urea, uric acid and creatinine. DZN intoxication significantly increased renal lipid peroxidation, and significant inhibition in antioxidant biomarkers including, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidant capacity. In addition, DZN significantly reduced serum acetylcholinestrase level. Moreover, It induced serum and kidney tumor necrosis factor-a level. Both ceftriaxone and vitamin C protect against DZN-induced serum as well as renal tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both ceftriaxone and vitamin C produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

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“…11,13 As the interest in selenium and its effects on human health is still growing, diverse compounds of selenium are still being studied, both inorganic and organic, Se-enriched natural products like probiotics, yeast and green tea, as well as selenium nanoparticles. 3,8,10,[14][15][16][17][18] Organic compounds have been widely studied recently due to the similarity of the activity of some of them (e.g., ebselen or diphenyl diselenide) to that shown by glutathione peroxidase. 19 Diphenyl diselenide has also been proved to possess many beneficial pharmacological properties: anti-hyperglycemic, anti-hyperlipidemic, hepatoprotective, antiulcer, and antidepressant.…”

Section: Introductionmentioning

confidence: 99%

Selenium – a fascinating antioxidant of protective properties

Kiełczykowska¹,

Kocot²,

Paździor³

et al. 2018

Adv Clin Exp Med

182

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Selenium is a trace element which fulfils important functions in the organism. Its deficit may cause acute disorders, but an overdose can also lead to severe consequences. The functions of selenium in the organism are mainly connected with its antioxidant properties, as it is an essential part of important antioxidant enzymes. Disturbances of oxidant balance have been found to be involved in the activity of numerous harmful factors as well as in the pathogenesis of diverse illnesses. Selenium administration has proved to be effective against the toxicity of many agents and the side effects of drugs. However, the narrow range between therapeutic and toxic doses of selenium, as well as the dependence of its effect on the applied form, dose and method of treatment, makes the choice of the most effective supplement a very complex issue. Divergent forms of selenium are still being studied, including both inorganic and organic compounds as well as Se-enriched natural products. The newest research has also involved selenium nanoparticles. The aim of this review is to present the great potential of selenium for protecting the organism against a wide variety of environmental pollutants, drugs and physical factors.

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Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon

Cited by 117 publications

References 43 publications

Neuro and renal toxicity induced by chlorpyrifos and abamectin in rats

Neuro and renal toxicity induced by chlorpyrifos and abamectin in rats

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Selenium – a fascinating antioxidant of protective properties

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